Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gillian Mackay"'
Autor:
Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero, Jim C. Norman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stim
Externí odkaz:
https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e
Autor:
Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J. van den Broek, Gillian MacKay, Colin Nixon, Sandeep Dhayade, Zachary T. Schug, Johan Vande Voorde, Karen Blyth, Eyal Gottlieb, Alexei Vazquez, Jurre J. Kamphorst
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 647-658 (2017)
Acetyl-CoA is a key metabolic intermediate with an important role in transcriptional regulation. The nuclear-cytosolic acetyl-CoA synthetase 2 (ACSS2) was found to sustain the growth of hypoxic tumor cells. It generates acetyl-CoA from acetate, but e
Externí odkaz:
https://doaj.org/article/c5f053a223f54e6b96b37ef17300aee2
Autor:
Marta Braga, Maciej Kaliszczak, Laurence Carroll, Zachary T. Schug, Kathrin Heinzmann, Nicoleta Baxan, Adrian Benito, Gabriel N. Valbuena, Stephen Stribbling, Alice Beckley, Gillian Mackay, Francesco Mauri, John Latigo, Chris Barnes, Hector Keun, Eyal Gottlieb, Eric O. Aboagye
Publikováno v:
Cancers, Vol 12, Iss 6, p 1703 (2020)
The monocarboxylate transporter 1 (MCT1) is a key element in tumor cell metabolism and inhibition of MCT1 with AZD3965 is undergoing clinical trials. We aimed to investigate nutrient fluxes associated with MCT1 inhibition by AZD3965 to identify possi
Externí odkaz:
https://doaj.org/article/03a16481ce5b4c99848b306059d9e247
Autor:
Rachana Patel, Janis Fleming, Ernest Mui, Carolyn Loveridge, Peter Repiscak, Arnaud Blomme, Victoria Harle, Mark Salji, Imran Ahmad, Katy Teo, Freddie C Hamdy, Ann Hedley, Niels van den Broek, Gillian Mackay, Joanne Edwards, Owen J Sansom, Hing Y Leung
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 4, Pp n/a-n/a (2018)
Abstract Metastatic castration‐resistant prostate cancer (mCRPC) is a lethal form of treatment‐resistant prostate cancer and poses significant therapeutic challenges. Deregulated receptor tyrosine kinase (RTK) signalling mediated by loss of tumou
Externí odkaz:
https://doaj.org/article/f68a51d6e42349948384f58cf1f57479
Autor:
Louisa G. Gordon, Doreen Nabukalu, Raymond J. Chan, David E. Goldsbury, Kim Hobbs, Lee Hunt, Deme J. Karikios, Gillian Mackay, Laura Muir, Lillian Leigh, Carla Thamm, Daniel Lindsay, Kate Whittaker, Megan Varlow, Jordana McLoone, on behalf of the COSA Financial Toxicity Working Group
Publikováno v:
Asia-Pacific Journal of Clinical Oncology. 19:126-135
To understand the opinions and current practices of health professionals on the topic of addressing cancer-related financial toxicity among patients.A cross-sectional online survey was distributed through Australian clinical oncology professional org
Autor:
Hing Y. Leung, Johan Vande Voorde, Owen J. Sansom, David Sumpton, Gillian Mackay, Victoria Lynch, David Watson, Tong Zhang, Ernest Mui, Janis Fleming, Linda K. Rushworth, Lisa Rodgers, Catriona A. Ford, Rachana Patel
Supplementary Data from Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58399c5d1b64ee38e80659428eee496a
https://doi.org/10.1158/0008-5472.22431806.v1
https://doi.org/10.1158/0008-5472.22431806.v1
Autor:
Jurre J. Kamphorst, Owen J. Sansom, Alexei Vazquez, Colin Nixon, Gillian Mackay, Giovanny Rodriguez Blanco, David Sumpton, Sergey Tumanov, Sigrid K. Fey, Andrew D. Campbell, Grace H. McGregor
Figure S1 shows the effect of statins on cholesterol and coenzyme Q levels and synthesis. Figure S2 shows statins reduce oxidative phosphorylation and hence increase glucose uptake and lactate secretion. Figure S3 shows the metabolic rewiring that oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c665bc489d2b0747f0e16b34c28e42
https://doi.org/10.1158/0008-5472.22424815.v1
https://doi.org/10.1158/0008-5472.22424815.v1
Autor:
Hing Y. Leung, Owen J. Sansom, Saverio Tardito, Gillian Mackay, Ann Hedley, Colin Nixon, Chara Ntala, Joanne Edwards, Linda K. Rushworth, Carolyn J. Loveridge, Agata Mrowinska, Gaurav Malviya, Ee Hong Tan, Victoria Harle, Arnaud Blomme, Meiling Gao, Ernest Mui, Imran Ahmad, Peter Repiscak, Elspeth A. Brzezinska, Rachana Patel
Inhibition of the androgen receptor (AR) is the main strategy to treat advanced prostate cancers. AR-independent treatment-resistant prostate cancer is a major unresolved clinical problem. Patients with prostate cancer with alterations in canonical W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7a1d8060b188bf0fcf742f9ea31f23
https://doi.org/10.1158/0008-5472.c.6511860.v1
https://doi.org/10.1158/0008-5472.c.6511860.v1
Autor:
Jurre J. Kamphorst, Owen J. Sansom, Alexei Vazquez, Colin Nixon, Gillian Mackay, Giovanny Rodriguez Blanco, David Sumpton, Sergey Tumanov, Sigrid K. Fey, Andrew D. Campbell, Grace H. McGregor
Statins are widely prescribed inhibitors of the mevalonate pathway, acting to lower systemic cholesterol levels. The mevalonate pathway is critical for tumorigenesis and is frequently upregulated in cancer. Nonetheless, reported effects of statins on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba7245ab5ee7689dadbdb1dc487a176
https://doi.org/10.1158/0008-5472.c.6511870
https://doi.org/10.1158/0008-5472.c.6511870
Autor:
Michael F. Olson, Paul Timpson, Marina Pajic, Claire Vennin, Gillian Mackay, David Sumpton, Jurre J. Kamphorst, Evdokia Michalopoulou, Mathieu Unbekandt, Lynn McGarry, Nikolaj Gadegaard, Alicja Jagiełło, Marie Francene Cutiongco, June Munro, Nicola Rath
The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previously report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06694ff8940566fb5d0a2d2bd7b2e376
https://doi.org/10.1158/0008-5472.c.6509924.v1
https://doi.org/10.1158/0008-5472.c.6509924.v1