Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gillian M. Danielsen"'
Autor:
Søren Østergaard, Ku-Chuan Hsiao, Jane Spetzler, Renuka C. Pillutla, Lauge Schäffer, Asser Sloth Andersen, James R. Beasley, Michael Lennick, Gillian M. Danielsen, Paul W. Fletcher, Per Hertz Hansen, Renee Brissette, Neil I. Goldstein, Jakob Brandt, Arthur J. Blume
Publikováno v:
Journal of Biological Chemistry. 277:22590-22594
We used phage display to generate surrogate peptides that define the hotspots involved in protein-protein interaction between insulin and the insulin receptor. All of the peptides competed for insulin binding and had affinity constants in the high na
Autor:
Svend Ludvigsen, Morten Schlein, Gillian M. Danielsen, Helle Birk Olsen, Niels C. Kaarsholm, Asser Sloth Andersen
Publikováno v:
Biochemistry. 40:13520-13528
Small molecules with insulin mimetic effects and oral availability are of interest for potential substitution of insulin injections in the treatment of diabetes. We have searched databases for compounds capable of mimicking one epitope of the insulin
Publikováno v:
Endocrinology. 142:276-289
The endosomal compartment of hepatic parenchymal cells contains an acidic endopeptidase, endosomal acidic insulinase (EAI), which hydrolyzes internalized insulin at a limited number of sites. Although the positions of these cleavages are partially kn
Publikováno v:
Diabetes. 42:1032-1040
To investigate the short-term effects of didecanoyl-L-alpha-phosphatidylcholine on the nasal mucosa and the mechanism by which didecanoyl-L-alpha-phosphatidylcholine enhances the nasal absorption of insulin, an in vitro model was developed. The mucos
Publikováno v:
Biochimie. 86(3)
We have investigated the functional relationships between insulin receptor (IR) trafficking, mitogenic signaling and mRNA expression in rat liver and primary hepatocytes. The low-K(d) insulin analogues [His(A8),His(B4), Glu(B10),His(B27)]-human insul
Autor:
Neil I. Goldstein, Jakob Brandt, Asser Sloth Andersen, Jane Spetzler, Søren Østergaard, Michael Lennick, Thomas Hoeg-Jensen, Arthur J. Blume, Lauge Schäffer, Ulla Ribel, Paul W. Fletcher, Per Hertz Hansen, Gillian M. Danielsen, Renee Brissette, Renuka C. Pillutla, Jan Markussen, Olga Dedova, Ku-Chuan Hsiao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(8)
Insulin is thought to elicit its effects by crosslinking the two extracellular α-subunits of its receptor, thereby inducing a conformational change in the receptor, which activates the intracellular tyrosine kinase signaling cascade. Previously we i
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 104:167-168
Publikováno v:
The Biochemical journal. 332
Receptor-mediated endocytosis and subsequent endosomal proteolysis of [125I]TyrA14-[HisA8,HisB4,GluB10,HisB27]insulin ([125I]TyrA14-H2 analogue), an insulin analogue exhibiting a high affinity for the insulin receptor, has been studied in liver paren
Autor:
Kirsten Drejer, Bo Falck Hansen, Finn C. Wiberg, Gillian M. Danielsen, Harald Klein, Anker G. Lundemose, Anders Robert Sorensen
The metabolic and mitogenic potencies of six different insulin analogues were determined by measuring glucose transport in primary adipocytes and DNA synthesis in CHO cells respectively. Three analogues showed a disproportionately high mitogenic pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2a3b5c042b66cb7f3d16c6ef6daaa8
https://europepmc.org/articles/PMC1217182/
https://europepmc.org/articles/PMC1217182/
Publikováno v:
Gastroenterology. 121:741-742