Zobrazeno 1 - 10 of 77 pro vyhledávání: '"Gillian M, Mackay"'
1
Akademický článek
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer
Autor: Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung
Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-21 (2022)
Abstract Despite the clinical benefit of androgen‐deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration‐resistant prostate cancer (CRPC). In this study, we identified thioeste
Externí odkaz: https://doaj.org/article/0b32d6de175042e18b789240104f3924
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2
Akademický článek
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Autor: Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian M. MacKay, Sarah-Maria Fendt, Sara Zanivan, Hing Y. Leung
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring o
Externí odkaz: https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc
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3
Akademický článek
Stratification of cancer and diabetes based on circulating levels of formate and glucose
Autor: Matthias Pietzke, Salvador Fernandez Arroyo, David Sumpton, Gillian M. Mackay, Begoña Martin-Castillo, Jordi Camps, Jorge Joven, Javier A. Menendez, Alexei Vazquez, On behalf of the METTEN study group
Publikováno v: Cancer & Metabolism, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Background Serum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particular, the increasing in
Externí odkaz: https://doaj.org/article/22428ceb5f4d4fe69c3782cb5800a37f
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4
Akademický článek
Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
Autor: Justine Bellier, Marie-Julie Nokin, Maurine Caprasse, Assia Tiamiou, Arnaud Blomme, Jean L. Scheijen, Benjamin Koopmansch, Gillian M. MacKay, Barbara Chiavarina, Brunella Costanza, Gilles Rademaker, Florence Durieux, Ferman Agirman, Naïma Maloujahmoum, Pino G. Cusumano, Pierre Lovinfosse, Hing Y. Leung, Frédéric Lambert, Vincent Bours, Casper G. Schalkwijk, Roland Hustinx, Olivier Peulen, Vincent Castronovo, Akeila Bellahcène
Publikováno v: Cell Reports, Vol 30, Iss 5, Pp 1400-1416.e6 (2020)
Summary: The use of cetuximab anti-epidermal growth factor receptor (anti-EGFR) antibodies has opened the era of targeted and personalized therapy in colorectal cancer (CRC). Poor response rates have been unequivocally shown in mutant KRAS and are ev
Externí odkaz: https://doaj.org/article/96932a30ac1e4a57b60f7bff8ef7fecf
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5
Akademický článek
Increased formate overflow is a hallmark of oxidative cancer
Autor: Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou, Alexei Vazquez
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of
Externí odkaz: https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd2
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