Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gillian Houlihan"'
Autor:
Hannes Mutschler, Alexander I Taylor, Benjamin T Porebski, Alice Lightowlers, Gillian Houlihan, Mikhail Abramov, Piet Herdewijn, Philipp Holliger
Publikováno v:
eLife, Vol 7 (2018)
Recombination, the exchange of information between different genetic polymer strands, is of fundamental importance in biology for genome maintenance and genetic diversification and is mediated by dedicated recombinase enzymes. Here, we describe an in
Externí odkaz:
https://doaj.org/article/27b3cb250f45472582dd0345df05c355
Autor:
John R. D. Hervey, Niklas Freund, Gillian Houlihan, Gurpreet Dhaliwal, Philipp Holliger, Alexander I. Taylor
Functional nucleic acids can be evolved in vitro using cycles of selection and amplification, starting from diverse-sequence libraries, which are typically restricted to natural or partially-modified polymer chemistries. Here, we describe the efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b3bee1e4a2bf5994b7df9e09e6356b
https://www.repository.cam.ac.uk/handle/1810/341274
https://www.repository.cam.ac.uk/handle/1810/341274
Autor:
Greggory M. Rice, Kevin M. Weeks, Gillian Houlihan, Matthew J. Smola, Catherine A. Giannetti, Philipp Holliger, Thomas W. Christy, Alain Laederach, Jing Wang, Nikolay V. Dokholyan
Publikováno v:
Biochemistry
Higher-order structure governs function for many RNAs. However, discerning this structure for large RNA molecules in solution is an unresolved challenge. Here, we present SHAPE-JuMP (selective 2'-hydroxyl acylation analyzed by primer extension and ju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3886067b0ebfbff2e4e6ee9d8446f682
https://doi.org/10.1021/acs.biochem.1c00270
https://doi.org/10.1021/acs.biochem.1c00270
Autor:
Nithya Subramanian, Philipp Holliger, Benjamin T. Porebski, Gillian Houlihan, Alexander I. Taylor, Sebastian Arangundy-Franklin
Publikováno v:
Nature Chemistry. 12:683-690
The ability of reverse transcriptases (RTs) to synthesize a complementary DNA from natural RNA and a range of unnatural xeno nucleic acid (XNA) template chemistries, underpins key methods in molecular and synthetic genetics. However, RTs have proven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ad38114856521837f93384a1f15a77
https://doi.org/10.1038/s41557-020-0502-8
https://doi.org/10.1038/s41557-020-0502-8
Publikováno v:
Accounts of Chemical Research
Conspectus Nucleic acids are a distinct form of sequence-defined biopolymer. What sets them apart from other biopolymers such as polypeptides or polysaccharides is their unique capacity to encode, store, and propagate genetic information (molecular h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67932aa530226b1fb20b0aeaf683dca8
https://doi.org/10.1021/acs.accounts.7b00056
https://doi.org/10.1021/acs.accounts.7b00056
Autor:
Alexander I. Taylor, Gillian Houlihan, Hannes Mutschler, Mikhail Abramov, Benjamin T. Porebski, Alice Lightowlers, Philipp Holliger, Piet Herdewijn
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Recombination, the exchange of information between different genetic polymer strands, is of fundamental importance in biology for genome maintenance and genetic diversification and is mediated by dedicated recombinase enzymes. Here, we describe an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c9862eec75ee97a6c4fd8447b8f060
http://europepmc.org/articles/PMC6289569
http://europepmc.org/articles/PMC6289569
Autor:
Philipp Holliger, Piet Herdewijn, Gillian Houlihan, Alexander I. Taylor, Mikhail Abramov, Hannes Mutschler, Alice Lightowlers
The spontaneous emergence of function from prebiotic pools of informational polymers is a central conjecture of current origin of life scenarios. However, the innate functional capacity of random genetic polymer pools is unknown. Here, we have examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc9c951643f4e87602f0d3d81af4e7b
https://doi.org/10.1101/320499
https://doi.org/10.1101/320499
Autor:
Hannes Mutschler, Philipp Holliger, Geoffrey M. Nelson, Alexander I. Taylor, Gillian Houlihan, Christopher Cozens
Publikováno v:
Angewandte Chemie. 127:15791-15794
Informationentragende Nukleinsauren sind universell uber 3′-5′-Bindungen verknupft. Regioisomere 2′-5′-Verknupfungen bilden sich dagegen unregelmasig wahrend der nichtenzymatischen RNA-Synthese und waren womoglich hilfreich fur die prabiotisc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22f18e4830433672f7e351bda6051af
https://doi.org/10.1002/ange.201508678
https://doi.org/10.1002/ange.201508678
Autor:
Philipp Holliger, Christopher Cozens, Geoffrey M. Nelson, Gillian Houlihan, Alexander I. Taylor, Hannes Mutschler
Publikováno v:
Angewandte Chemie (International Ed. in English)
Information‐bearing nucleic acids display universal 3′‐5′ linkages, but regioisomeric 2′‐5′ linkages occur sporadically in non‐enzymatic RNA synthesis and may have aided prebiotic RNA replication. Herein we report on the enzymatic syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a396c73344e53e1daf91013bb7ab8642
http://europepmc.org/articles/PMC4736440
http://europepmc.org/articles/PMC4736440
Publikováno v:
Current opinion in biotechnology. 48
Organic chemistry has systematically probed the chemical determinants of function in nucleic acids by variation to the nucleobase, sugar ring and backbone moieties to build synthetic genetic polymers. Concomitantly, protein engineering has advanced t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4039fcc4db4d6a5db6cc383b005ba20
https://pubmed.ncbi.nlm.nih.gov/28601700
https://pubmed.ncbi.nlm.nih.gov/28601700