Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Gillian Harcourt"'
Autor:
Andrew James Godkin, Rodney E. Phillips, Paul Klenerman, Michaela Lucas, Maria Kantzanou, Gillian Harcourt
SUMMARY CD4+ T lymphocyte responses are thought to play a major role in control of the hepatitis C virus (HCV). Few, however, have been mapped down to the level of peptide and HLA restriction. Furthermore, the ability of such T cells to respond to vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc954a8acfbdd78c471b9fbb14d27ae
https://ora.ox.ac.uk/objects/uuid:f8328541-5e88-4801-b800-8b18a9c97408
https://ora.ox.ac.uk/objects/uuid:f8328541-5e88-4801-b800-8b18a9c97408
Mutation is one way in which RNA viruses evade the destructive actions of CD8+ cytotoxic lymphocytes. New research shows that they employ the same method to escape attack by CD4+ T cells. (pages 795–800)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bae7288ca637f0aa6c5ad4a890954c
https://doi.org/10.1038/89892
https://doi.org/10.1038/89892
Autor:
Hansjakob Furrer, Silvana Gaudieri, Janine Rohrbach, Enos Bernasconi, Meri Gorgievski, Huldrych F. Günthard, B. Hirschel, Nicola Robinson, Matthias Hoffmann, Andri Rauch, Gillian Harcourt, Emma Hammond, Paul Klenerman, Olivia Keiser, Amalio Telenti, Manuel Battegay
Publikováno v:
Gut, Vol. 59, No 9 (2010) pp. 1252-1258
BACKGROUND: Hepatitis C virus (HCV) infection is a major cause of morbidity in HIV infected individuals. Coinfection with HIV is associated with diminished HCV-specific immune responses and higher HCV RNA levels. AIMS: To investigate whether long-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64fa2715f6e1417e45fa699a4935032
https://doi.org/10.1136/gut.2009.205971
https://doi.org/10.1136/gut.2009.205971
Autor:
Elizabeth Taylor, Thomas J. Scriba, Gillian Harcourt, Paul Klenerman, S. Bounds, Nasser Semmo
SummaryHuman cytomegalovirus (CMV) infection is normally controlled effectively by the immune response, including CD4+ T cells. Large numbers of these cells are present in healthy seropositive individuals but their loss in immunosuppression leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b9eeda5f9f295ecea67ca3f2dd12fd
https://doi.org/10.1111/j.1365-2249.2006.03193.x
https://doi.org/10.1111/j.1365-2249.2006.03193.x
Autor:
Eleanor Barnes, Scott M. Ward, Maria Kantzanou, Gillian Harcourt, G.M. Dusheiko, Harvki Komatsu, Michaela Lucas, Paul Klenerman
Hepatitis C virus (HCV) has infected over 170 million people world wide, and in the majority sets up a chronic infection associated with hepatic inflammation. How it evades host immunity, particularly CD8+ T cells (CTL) is unclear, but two major fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4001f45aa4e633738b91fc615c56e0ca
https://ora.ox.ac.uk/objects/uuid:0b3d6273-fb76-44c9-885d-2e52767cb175
https://ora.ox.ac.uk/objects/uuid:0b3d6273-fb76-44c9-885d-2e52767cb175
Autor:
Eleanor Barnes, Nasser Semmo, Gillian Harcourt, Neil Smith, Craig J. Taylor, John Kurtz, Paul Klenerman
Blood donors are routinely screened for hepatitis C virus infection. Some individuals have weak or restricted virus-specific antibody responses, and are classed as indeterminate. Such donors are almost always negative for viral RNA in blood. We postu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29498776eaa145f66f809dc8d6baff6d
https://doi.org/10.1016/s0140-6736(05)17787-3
https://doi.org/10.1016/s0140-6736(05)17787-3
Publikováno v:
The Journal of General Virology
Human and animal model evidence suggests that CD4+ T cells play a critical role in the control of chronic hepatitis C virus (HCV) infection. However, despite their importance, the mechanism behind the failure of such populations in chronic disease is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6dd100a90ea7d9a77b6566bd739402
https://doi.org/10.1099/vir.0.017699-0
https://doi.org/10.1099/vir.0.017699-0
Publikováno v:
Gut. 55:1484-1487
BACKGROUND: Human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection is a common and complex clinical problem in which loss of immunological control of HCV occurs, with increased HCV viral load and more aggressive liver disease. Cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017b4adf3e9bea4c47da5d41c8839a9f
https://doi.org/10.1136/gut.2005.083758
https://doi.org/10.1136/gut.2005.083758
Autor:
Michaela Lucas, Gillian Harcourt, Rodney E. Phillips, Eleanor Barnes, Isabelle Sheridan, Paul Klenerman
Publikováno v:
Journal of Viral Hepatitis. 11:324-331
Cellular immunity plays an important role in the control of persistent virus infections such as hepatitis C virus (HCV). Antiviral CD4(+) T cell responses have been shown to accompany resolution of acute disease and there is also a consistent associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e434aac0a5a5cbe5919ba7b816cd9ed
https://doi.org/10.1111/j.1365-2893.2004.00516.x
https://doi.org/10.1111/j.1365-2893.2004.00516.x