MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

Autor: Gillian Fitzgerald, Guillermo Turiel, Tatiane Gorski, Inés Soro-Arnaiz, Jing Zhang, Nicola C. Casartelli, Evi Masschelein, Nicola A. Maffiuletti, Reto Sutter, Michael Leunig, Jean Farup, Katrien De Bock

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-21 (2023)

Using single nuclei and single cell RNA-seq, 3 FAP cell subpopulations are identified in human skeletal muscle, with an MME+ subset showing increased adipogenic potential under fatty infiltration conditions.

Externí odkaz: https://doaj.org/article/6235bdf1b70e4784936defbd604d3383

Advances in treatment of axial spondyloarthritis are associated with improved patient outcomes: data from the Ankylosing Spondylitis Registry of Ireland (ASRI)

Autor: Sinead Maguire, Gillian Fitzgerald, Phil Gallagher, Finbar O’Shea

Publikováno v: Rheumatology International. 42:831-838

The Ankylosing Spondylitis Registry of Ireland (ASRI) captures both radiographic and non-radiographic axial spondyloarthritis (axSpA) in a large, well characterised cohort. This is a valuable resource for studies in therapeutics and burden of disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8323dd48830b225d65080cdf0c06104
https://doi.org/10.1007/s00296-021-05067-z

MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

Autor: Gillian Fitzgerald, Guillermo Turiel, Tatiane Gorski, Inés Soro-Arnaiz, Jing Zhang, Nicola C Casartelli, Evi Masschelein, Nicola A Maffiuletti, Reto Sutter, Michael Leunig, Jean Farup, Katrien De Bock

Summary/AbstractFatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated via the adipogenic differentiation of fibro-adipogenic progenitors (FAPs). We used single-nuclei and single- cell RNA sequencing to chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e39aa0cb4592af3d1468b6626fc4e620
https://doi.org/10.1101/2022.04.22.489158

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Autor: Peter Carmeliet, Louise Deldicque, Sunghoon Kim, Shimin Zhao, Leigh Breen, Gillian Fitzgerald, Koen Veys, Peppi Koivunen, Benoit Smeuninx, Inés Soro-Arnaiz, Katrien De Bock, Bert Blaauw, Gommaar D'Hulst, Evi Masschelein

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)

mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1KO) reduces muscle mass. PHD1KO musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed65d3a9ba21caa35226b725b5c4e464
https://doaj.org/article/57ce964136154da49cd0e8f1b72242c1

Employment and Functional Ability in Men and Women With Axial Spondyloarthritis as Described in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry

Autor: Finbar O'Shea, Gillian Fitzgerald, Sinead Maguire

Publikováno v: The Journal of rheumatology. 48(12)

We read with interest the recent article from Mease et al1 regarding the analysis of men and women with axial spondyloarthritis (axSpA) captured in the Corrona Psoriatic Arthritis/ Spondyloarthritis Registry. Dedicated comparative analysis in large,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d26148d65dbb3e73c174b0f0a9203df
https://pubmed.ncbi.nlm.nih.gov/34470796