Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Gillian Coughlan"'
Autor:
Peter Zhukovsky, Earvin S. Tio, Gillian Coughlan, David A. Bennett, Yanling Wang, Timothy J. Hohman, Diego A. Pizzagalli, Benoit H. Mulsant, Aristotle N. Voineskos, Daniel Felsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as depression and vascular disease, do not affect all individuals in the same way, li
Externí odkaz:
https://doaj.org/article/b36664d6b38549e59bb345531b88ac85
Autor:
Catherine E. Munro, Rory Boyle, Xi Chen, Gillian Coughlan, Christopher Gonzalez, Roos J. Jutten, Jairo Martinez, Irina Orlovsky, Talia Robinson, Emma Weizenbaum, Celina F. Pluim, Yakeel T. Quiroz, Jennifer R. Gatchel, Patrizia Vannini, Rebecca Amariglio
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract Subjective cognitive decline (SCD) is defined as self‐experienced, persistent concerns of decline in cognitive capacity in the context of normal performance on objective cognitive measures. Although SCD was initially thought to represent t
Externí odkaz:
https://doaj.org/article/06662271a8f44732b3c6a4fc4c7f509b
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0278239 (2023)
Path integration changes may precede a clinical presentation of Alzheimer's disease by several years. Studies to date have focused on how spatial cell changes affect path integration in preclinical AD. However, vestibular input is also critical for i
Externí odkaz:
https://doaj.org/article/ceb3e2d2f59f4be49ecccc0b2580b81d
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 4, Iss , Pp 100155- (2023)
Vascular cognitive impairment (VCI) is the second most prevalent form of dementia, but little is known about the early cognitive and neuroimaging markers. Spatial navigation deficits are an emerging marker for Alzheimer's disease (AD), yet less is kn
Externí odkaz:
https://doaj.org/article/71bd87d1f26348e3921a4ec8216f7917
Autor:
Vaisakh Puthusseryppady, Sol Morrissey, Min Hane Aung, Gillian Coughlan, Martyn Patel, Michael Hornberger
Publikováno v:
JMIR Aging, Vol 5, Iss 2, p e28222 (2022)
BackgroundSpatial disorientation is one of the earliest and most distressing symptoms seen in patients with Alzheimer disease (AD) and can lead to them getting lost in the community. Although it is a prevalent problem worldwide and is associated with
Externí odkaz:
https://doaj.org/article/75fccc561e5d4657b50b9ec524eb9d5c
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction The apolipoprotein E (APOE) ε4 allele is the greatest genetic risk factor for Alzheimer's disease (AD). Our aim was to identify the structural brain measures that mitigate the negative effect of APOE ε4 on cognition, which wou
Externí odkaz:
https://doaj.org/article/8f683e3f6c4147348014aaccad38b140
Publikováno v:
Frontiers in Human Neuroscience, Vol 14 (2020)
Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been less explored in Vascular Cognitive Impairment (VCI), de
Externí odkaz:
https://doaj.org/article/ba00d7e284fd4a4da4efec12c0d55897
Autor:
Gillian Coughlan, Vaisakh Puthusseryppady, Ellen Lowry, Rachel Gillings, Hugo Spiers, Anne-Marie Minihane, Michael Hornberger
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239077 (2020)
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cog
Externí odkaz:
https://doaj.org/article/51af16cb5fea46fa8b73856404754047
Autor:
Gillian Coughlan, Emma Flanagan, Stephen Jeffs, Maxime Bertoux, Hugo Spiers, Eneida Mioshi, Michael Hornberger
Publikováno v:
Dementia & Neuropsychologia, Vol 12, Iss 1, Pp 85-91
ABSTRACT Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective:
Externí odkaz:
https://doaj.org/article/f5bc1a556ea84be1a1c42ff6059cc870
Autor:
Gillian Coughlan, Nichole R Bouffard, Ali Golestani, Preston P Thakral, Daniel L Schacter, Cheryl Grady, Morris Moscovitch
Publikováno v:
Cerebral Cortex. 33:3255-3264
Transcranial magnetic stimulation (TMS) delivered to the angular gyrus (AG) affects hippocampal function and associated behaviors (Thakral PP, Madore KP, Kalinowski SE, Schacter DL. Modulation of hippocampal brain networks produces changes in episodi