Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gillian Coakley"'
Autor:
Haozhe Wang, Kristian Barry, Aidil Zaini, Gillian Coakley, Mati Moyat, Carmel P Daunt, Lakshanie C Wickramasinghe, Rossana Azzoni, Roxanne Chatzis, Bibek Yumnam, Mali Camberis, Graham Le Gros, Olaf Perdijk, Jaime P P Foong, Joel C Bornstein, Benjamin J Marsland, Nicola L Harris
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1011766 (2024)
Intestinal helminth infection triggers a type 2 immune response that promotes a 'weep-and sweep' response characterised by increased mucus secretion and intestinal hypermotility, which function to dislodge the worm from its intestinal habitat. Recent
Externí odkaz:
https://doaj.org/article/36ebdfe1069a4be6ad32d6752f7b22f2
Publikováno v:
Bio-Protocol, Vol 10, Iss 24 (2020)
Hookworms are skin penetrating parasites, however in the laboratory the hookworm model Nippostrongylus brasiliensis, the parasite is traditionally administered subcutaneously bypassing the skin (epidermis and dermis). Here, we describe two complement
Externí odkaz:
https://doaj.org/article/ecaf5ef013824ce08939dfa702a39d96
Autor:
Gillian Coakley, Jana L. McCaskill, Jessica G. Borger, Fabio Simbari, Elaine Robertson, Marissa Millar, Yvonne Harcus, Henry J. McSorley, Rick M. Maizels, Amy H. Buck
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1545-1557 (2017)
Recent studies have demonstrated that many parasites release extracellular vesicles (EVs), yet little is known about the specific interactions of EVs with immune cells or their functions during infection. We show that EVs secreted by the gastrointest
Externí odkaz:
https://doaj.org/article/8bb9b643cf804bdaa9b018beea56deb6
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/056777b49e99424db31f099d1c438f36
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 11, Pp n/a-n/a (2019)
Abstract Type 2 immunity has recently emerged as a critical player in metabolic status, with numerous studies investigating the role of type 2 immune cells within adipose tissue. Metabolic dysfunction is often characterised as a low‐grade or chroni
Externí odkaz:
https://doaj.org/article/7d5a962751a2477b87b09efca5320bcb
Autor:
Fabio Simbari, Jana McCaskill, Gillian Coakley, Marissa Millar, Rick M. Maizels, Gemma Fabriás, Josefina Casas, Amy H. Buck
Publikováno v:
Journal of Extracellular Vesicles, Vol 5, Iss 0, Pp 1-16 (2016)
Extracellular vesicles (EVs) mediate communication between cells and organisms across all 3 kingdoms of life. Several reports have demonstrated that EVs can transfer molecules between phylogenetically diverse species and can be used by parasites to a
Externí odkaz:
https://doaj.org/article/204cfd2686c648059f8cba41d595cba7
Autor:
Mati Moyat, Luc Lebon, Olaf Perdijk, Lakshanie C. Wickramasinghe, Mario M. Zaiss, Ilaria Mosconi, Beatrice Volpe, Nadine Guenat, Kathleen Shah, Gillian Coakley, Tiffany Bouchery, Nicola L. Harris
Publikováno v:
Mucosal Immunology. 15:1283-1295
Soil-transmitted helminths cause widespread disease, infecting ~1.5 billion people living within poverty-stricken regions of tropical and subtropical countries. As adult worms inhabit the intestine alongside bacterial communities, we determined wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25c516d63b4e006f8f7813b0e9dcaf1
https://doi.org/10.1038/s41385-022-00498-8
https://doi.org/10.1038/s41385-022-00498-8
Publikováno v:
International Journal for Parasitology
Graphical abstract
Highlights • Current vaccine candidates against helminth infection have shown limited success. • Helminths release extracellular vesicles (EVs) which act on host cells and are a rich source of antigens for new vaccines.
Highlights • Current vaccine candidates against helminth infection have shown limited success. • Helminths release extracellular vesicles (EVs) which act on host cells and are a rich source of antigens for new vaccines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c3d8a6d2739816a31f4312571f0eb7
https://doi.org/10.1016/j.ijpara.2020.04.011
https://doi.org/10.1016/j.ijpara.2020.04.011
Autor:
Tiffany Bouchery, Beatrice Volpe, Rory Doolan, Gillian Coakley, Mati Moyat, Julia Esser‐von Bieren, Lakshanie C Wickramasinghe, Margaret L Hibbs, Javier Sotillo, Mali Camberis, Graham Le Gros, Nemat Khan, David Williams, Nicola L Harris
Publikováno v:
Immunol. Cell Biol. 100, 223-234 (2022)
Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87424baf645b2c2de86247a0daf18d16
https://pubmed.ncbi.nlm.nih.gov/35156238
https://pubmed.ncbi.nlm.nih.gov/35156238
Autor:
Aline Ignacio, Kathleen Shah, Jeremiah Bernier-Latmani, Yasmin Köller, Gillian Coakley, Mati Moyat, Romain Hamelin, Florence Armand, Nick C. Wong, Hena Ramay, Carolyn A. Thomson, Regula Burkhard, Haozhe Wang, Antoine Dufour, Markus B. Geuking, Braedon McDonald, Tatiana V. Petrova, Nicola L. Harris, Kathy D. McCoy
Publikováno v:
Immunity. 55:1250-1267.e12
The intestine harbors a large population of resident eosinophils, yet the function of intestinal eosinophils has not been explored. Flow cytometry and whole-mount imaging identified eosinophils residing in the lamina propria along the length of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17326c71fdafa0e72696a379a7e51577
https://doi.org/10.1016/j.immuni.2022.05.014
https://doi.org/10.1016/j.immuni.2022.05.014