Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Gillian C. Lynch"'
Autor:
Abimbola O. Kolawole, Hong Q. Smith, Sophia A. Svoboda, Madeline S. Lewis, Michael B. Sherman, Gillian C. Lynch, B. Montgomery Pettitt, Thomas J. Smith, Christiane E. Wobus
Publikováno v:
mSphere, Vol 2, Iss 5 (2017)
ABSTRACT Ideal antiviral vaccines elicit antibodies (Abs) with broad strain recognition that bind to regions that are difficult to mutate for escape. Using 10 murine norovirus (MNV) strains and 5 human norovirus (HuNoV) virus-like particles (VLPs), w
Externí odkaz:
https://doaj.org/article/8c3e915739ee40cdb50d1aac4ea2b75c
Publikováno v:
Biophysical Journal. 121:527a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212da1a0f0149c625861863b35bbdf77
https://doi.org/10.1016/j.bpj.2021.11.2778
https://doi.org/10.1016/j.bpj.2021.11.2778
Publikováno v:
Protein Sci
Glutamate dehydrogenase (GDH) is a target for treating insulin-related disorders, such as hyperinsulinism hyperammonemia syndrome. Modeling native ligand binding has shown promise in designing GDH inhibitors and activators. Our computational investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc122e23b183a7ab298fb8b6e4bdc627
https://europepmc.org/articles/PMC6863735/
https://europepmc.org/articles/PMC6863735/
Publikováno v:
Biochim Biophys Acta Gen Subj
The Lac system of genes has been an important model system in understanding gene regulation. When the dimer lac repressor protein binds to the correct DNA sequence, the hinge region of the protein goes through a disorder to order transition. The hing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20869da734193d6c096b2e32c7574fb9
https://doi.org/10.1016/j.bbagen.2020.129538
https://doi.org/10.1016/j.bbagen.2020.129538
We calculate the solubility limit of pentapeptides in water by simulating the phase separation in an oversaturated aqueous solution. The solubility limit order followed by our model peptides (GGRGG > GGDGG > GGGGG > GGVGG > GGQGG > GGNGG > GGFGG) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b10f6504d85cde5fb3857de60b69acb
https://europepmc.org/articles/PMC5909690/
https://europepmc.org/articles/PMC5909690/
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1850:923-931
Background Solvation density locations are important for protein dynamics and structure. Knowledge of the preferred hydration sites at biomolecular interfaces and those in the interior of cavities can enhance understanding of structure and function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90657e5e6ca8baf19a04704f72b91fbf
https://doi.org/10.1016/j.bbagen.2014.09.020
https://doi.org/10.1016/j.bbagen.2014.09.020
Autor:
B. Montgomery Pettitt, Melinda Rezeli, Paul A. Wadsworth, Ákos Végvári, Frederick F. Lang, György Marko-Varga, Gillian C. Lynch, Erik P. Sulman, Ekaterina Mostovenko, Carol L. Nilsson, Cheryl F. Lichti, Qianghu Wang
Publikováno v:
Journal of Proteome Research
Novel proteoforms with single amino acid variations represent proteins that often have altered biological functions but are less explored in the human proteome. We have developed an approach, searching high quality shotgun proteomic data against an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463765a5b1af439a4c420e3f2baa78e6
https://doi.org/10.1021/pr500810g
https://doi.org/10.1021/pr500810g
Publikováno v:
Biopolymers. 99:448-459
Factor VIII (FVIII) is the blood coagulation protein which when defective or deficient causes for hemophilia A, a severe hereditary bleeding disorder. Activated FVIII (FVIIIa) is the cofactor to the serine protease factor IXa (FIXa) within the membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48df812bea3532c751a0ebb27cdad8c8
https://doi.org/10.1002/bip.22199
https://doi.org/10.1002/bip.22199
Publikováno v:
The Journal of Physical Chemistry B. 115:547-556
We calculate the water and ion spatial distributions around charged oligonucleotides using a renormalized three-dimensional reference interaction site theory coupled with the HNC closure. Our goal is to understand the balance between inter-DNA strand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2879d7c941660f998d50b428cce117d5
https://doi.org/10.1021/jp107383s
https://doi.org/10.1021/jp107383s
Publikováno v:
Protein Science. 19:1011-1022
The transfer model implying additivity of the peptide backbone free energy of transfer is computationally tested. Molecular dynamics simulations are used to determine the extent of change in transfer free energy (ΔGtr) with increase in chain length
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::799627fba227f93729a05b6cfd1c7891
https://doi.org/10.1002/pro.378
https://doi.org/10.1002/pro.378