Chromosome analysis in a case of a plutonium contaminated wound

Autor: Anthony E. Riddell, Gillian B. Curwen, E. Janet Tawn, David Lloyd, Elizabeth A. Ainsbury

Publikováno v: Journal of Radiological Protection. 37:N13-N19

Chromosome analysis of peripheral blood lymphocytes was undertaken over a 10 year period following an intake of plutonium through a hand wound. Frequencies of cells with unstable complex aberrations remained high throughout this time, probably reflec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab40b484dd30e8b6a39d95eef68ce5ab
https://doi.org/10.1088/1361-6498/aa595c

Chromosome aberrations in workers occupationally exposed to tritium

Autor: Anthony E. Riddell, Gillian B. Curwen, E. Janet Tawn

Publikováno v: Tawn, E J, Curwen, G B & Riddell, A E 2018, ' Chromosome aberrations in workers occupationally exposed to tritium ', Journal of Radiological Protection, vol. 38, no. 2, pp. N9-N16 . https://doi.org/10.1088/1361-6498/aab0d0

This paper reports the findings of an historical chromosome analysis for unstable aberrations, undertaken on 34 nuclear workers with monitored exposure to tritium. The mean recorded β-particle dose from tritium was 9.33 mGy (range 0.25–79.71 mGy)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b391c449e4e266c7ba19b23118766e64
https://pubmed.ncbi.nlm.nih.gov/29589589

A study of DNA damage recognition and repair gene polymorphisms in relation to cancer predisposition and G2 chromosomal radiosensitivity

Autor: Gillian B. Curwen, Elizabeth J. Tawn, John D. Boice, Jeanette Falck Winther, Samantha Murphy

Publikováno v: Environmental and Molecular Mutagenesis. 52:72-76

The previously reported association of the APEX Asp148Glu single nucleotide polymorphism (SNP) with cancer, and the suggestion of associations of the XRCC3 Thr241Met and hOGG1 Ser326Cys SNP sites with G(2) chromosomal radiosensitivity were investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ad891496b900d52ef9f014f1695c1b
https://doi.org/10.1002/em.20633

G2 checkpoint control and G2 chromosomal radiosensitivity in cancer survivors and their families

Autor: Jeanette Falck Winther, Kevin K. Cadwell, Gillian B. Curwen, E. Janet Tawn, John D. Boice

Publikováno v: Mutagenesis. 26:291-294

Significant inter-individual variation in G(2) chromosomal radiosensitivity, measured as radiation-induced chromatid-type aberrations in the subsequent metaphase, has been reported in peripheral blood lymphocytes of both healthy individuals and a ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3cdc81dc5da02c5c56e8c0e10d9ea0
https://doi.org/10.1093/mutage/geq087

Chromosome analysis in childhood cancer survivors and their offspring—No evidence for radiotherapy-induced persistent genomic instability

Autor: Caroline A. Whitehouse, Marilyn Stovall, Catherine Rechnitzer, Per Guldberg, Jeanette Falck Winther, Gillian B. Curwen, Henrik Daa Schrøder, John D. Boice, Gwen S. Rees, Jørgen H. Olsen, E. Janet Tawn

Publikováno v: Tawn, EJ, Whitehouse, CA, Winther, JF, Curven, GB, Rees, GS, Stovall, M, Olsen, JH, Guldberg, P, Rechnitzer, C, Schrøder, H & Boyce, JD 2005, ' Chromosome analysis in childhood cancer survivors and their offspring-No evidence for radiotherapy-induced persistent genomic instability. ', Mutation Research-Reviews in Mutation Research, vol. 583, pp. 198-206 .

Suggestions that the induction of genomic instability could play a role in radiation-induced carcinogenesis and heritable disease prompted the investigation of chromosome instability in relation to radiotherapy for childhood cancer. Chromosome analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b8df6c007c86e095a343ca79b82ee4
https://doi.org/10.1016/j.mrgentox.2005.03.007