Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490

Autor: Victoria J. M. Reid, Wesley K. X. McLoughlin, Kalyani Pandya, Holly Stott, Monika Iškauskienė, Algirdas Šačkus, Judit A. Marti, Dominic Kurian, Thomas M. Wishart, Christophe Lucatelli, Dan Peters, Gillian A. Gray, Andrew H. Baker, David E. Newby, Patrick W. F. Hadoke, Adriana A. S. Tavares, Mark G. MacAskill

Publikováno v: EJNMMI Research, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Background Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targeting these processes cou

Externí odkaz: https://doaj.org/article/b3fa38c72c4943ada2374cbe0f7b0709

Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy

Autor: Jacek Kwiecinski, Ross J. Lennen, Gillian A. Gray, Gary Borthwick, Lyndsey Boswell, Andrew H. Baker, David E. Newby, Marc R. Dweck, Maurits A. Jansen

Publikováno v: Journal of Cardiovascular Magnetic Resonance, Vol 22, Iss 1, Pp 1-11 (2020)

Abstract Background Myocardial fibrosis is observed in multiple cardiac conditions including hypertension and aortic stenosis. Excessive fibrosis is associated with adverse clinical outcomes, but longitudinal human data regarding changes in left vent

Externí odkaz: https://doaj.org/article/85c00658de8e4f9f9cc2e07774bfd95e

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

Autor: Olivia Matthews, Emma E. Morrison, John D. Tranter, Philip Starkey Lewis, Iqbal S. Toor, Abhishek Srivastava, Rebecca Sargeant, Helen Rollison, Kylie P. Matchett, Timothy J. Kendall, Gillian A. Gray, Chris Goldring, Kevin Park, Laura Denby, Neeraj Dhaun, Matthew A. Bailey, Neil C. Henderson, Dominic Williams, James W. Dear

Publikováno v: EBioMedicine, Vol 62, Iss , Pp 103092- (2020)

Background: Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to investigate microRNA transfer from liver to kidney. Methods: Dicerflox/flox mic

Externí odkaz: https://doaj.org/article/6471fb5992d44958b700cf85b5053236

Corticosteroid Receptors in Cardiac Health and Disease

Autor: Jessica R, Ivy, Gillian A, Gray, Megan C, Holmes, Martin A, Denvir, Karen E, Chapman

Publikováno v: Advances in experimental medicine and biology. 1390

Nuclear receptors play a central role in both energy metabolism and cardiomyocyte death and survival in the heart. Recent evidence suggests they may also influence cardiomyocyte endowment. Although several members of the nuclear receptor family play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6279b29a1f873c2dbfd9fac3a4640153
https://pubmed.ncbi.nlm.nih.gov/36107315

Preclinical models of myocardial infarction: from mechanism to translation

Autor: Gillian A. Gray, Stuart A. Nicklin, Tamara P. Martin, Ali Abdullah I. Zaeri, Dylan O'Toole, Eilidh A MacDonald, Ali Ali Mohamed Elbassioni, Christopher M. Loughrey

Publikováno v: Martin, T P, Macdonald, E A, Elbassioni, A A M, O'toole, D, Zaeri, A A I, Nicklin, S A, Gray, G A & Loughrey, C M 2021, ' Preclinical models of myocardial infarction: from mechanism to translation ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15595

Approximately 7 million people are affected by acute myocardial infarction (MI) each year, and despite significant therapeutic and diagnostic advancements, MI remains a leading cause of mortality worldwide. Preclinical animal models have significantl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e739c0043aecfa1fac6673e6fb50a38
https://doi.org/10.1111/bph.15595