Výsledky vyhledávání - "Gillian, Vandekerkhove"

Akademický článek

A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes

Autor: Elie J. Ritch, Cameron Herberts, Evan W. Warner, Sarah W. S. Ng, Edmond M. Kwan, Jack V. W. Bacon, Cecily Q. Bernales, Elena Schönlau, Nicolette M. Fonseca, Veda N. Giri, Corinne Maurice-Dror, Gillian Vandekerkhove, Steven J. M. Jones, Kim N. Chi, Alexander W. Wyatt

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)

Abstract Specific classes of DNA damage repair (DDR) defect can drive sensitivity to emerging therapies for metastatic prostate cancer. However, biomarker approaches based on DDR gene sequencing do not accurately predict DDR deficiency or treatment b

Externí odkaz: https://doaj.org/article/857049a6c5d347b5818113b423d91b16

Zobrazit plný text záznamu

Akademický článek

Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

In metastatic urothelial carcinoma, it has not been established whether circulating tumor DNA (ctDNA) can replace archival primary tissue to assess mutations and biomarkers. Here, the authors show high mutation concordance between ctDNA and tumour ti

Externí odkaz: https://doaj.org/article/a2f42ea8d98a4db587379bb0ba66d3fe

Zobrazit plný text záznamu

Akademický článek

Circulating Tumour DNA as a Biomarker Source in Metastatic Prostate Cancer

Autor: Gillian Vandekerkhove, Alexander Wyatt

Publikováno v: Société Internationale d’Urologie Journal, Vol 1, Iss 1, Pp 39-48 (2020)

Tumour molecular features are increasingly linked to treatment response and patient prognosis in advanced prostate cancer. Plasma cell-free circulating tumour DNA (ctDNA) isolated from a minimally invasive blood draw offers a convenient source of tum

Externí odkaz: https://doaj.org/article/87d8f825bba747daace85e51394320e6

Zobrazit plný text záznamu

Akademický článek

Development of secondary urothelial carcinoma following complete response to immune checkpoint inhibitors

Autor: Jean-Michel Lavoie, Gillian Vandekerkhove, Andrew J. Murtha, Gang Wang, Alexander W. Wyatt, Bernhard J. Eigl

Publikováno v: Urology Case Reports, Vol 39, Iss , Pp 101762- (2021)

The management of metastatic urothelial cancer is rapidly evolving since immune checkpoint inhibitors were introduced. We present the case of a patient with metastatic upper tract urothelial cancer who had a complete response to durvalumab and tremel

Externí odkaz: https://doaj.org/article/ff2ebdbc93ad43f0bb25309772f79d18

Zobrazit plný text záznamu

Somatic Features of Response and Relapse in Non–muscle-invasive Bladder Cancer Treated with Bacillus Calmette-Guérin Immunotherapy

Autor: Jack V.W. Bacon, David C. Müller, Elie Ritch, Matti Annala, Sarah G. Dugas, Cameron Herberts, Gillian Vandekerkhove, Helge Seifert, Tobias Zellweger, Peter C. Black, Lukas Bubendorf, Alexander W. Wyatt, Cyrill A. Rentsch

Publikováno v: European Urology Oncology. 5:677-686

High-risk non-muscle-invasive bladder cancer (NMIBC) is treated with bacillus Calmette-Guérin (BCG), but relapse is common. Improvement of patient outcomes requires better understanding of links between BCG resistance and genomic driver alterations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ced6a7083906e91332a10873856aec
https://doi.org/10.1016/j.euo.2021.11.002

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání