Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gillian, Groeger"'
Steroids are routinely used to treat inflammation throughout the human body. Indeed, for decades, glucocorticoids have been used to reduce inflammatory processes in retinal eye disease. Most recently, their direct protective effects on photoreceptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb9141f78b77fe42fc322fb54e81353
https://doi.org/10.1039/9781788013666-00113
https://doi.org/10.1039/9781788013666-00113
Publikováno v:
Journal of Neuroscience Methods. 199:26-34
This study uses an in vitro rd10 mouse model to quantify and compare the ability of the monopolar and the (concentric) bipolar electrode configurations for subretinal stimulation. To allow for results which can be directly compared an identical regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829b6c59470118e3f86ae41504e18bad
https://doi.org/10.1016/j.jneumeth.2011.04.017
https://doi.org/10.1016/j.jneumeth.2011.04.017
Autor:
Colm O'Brien, Stephen M. J. Farrell, Thomas G. Cotter, Gillian Groeger, Sorcha Finnegan, Lavinia Bhatt
Publikováno v:
European Journal of Neuroscience. 33:632-641
In many retinal diseases, it is the death of photoreceptors that leads to blindness. In previous in vitro and in vivo studies, basic fibroblast growth factor (bFGF) has been shown to increase retinal cell survival. More recently, reactive oxygen spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6cb40764cff8c2f6d3c64e1de1088de
https://doi.org/10.1111/j.1460-9568.2010.07559.x
https://doi.org/10.1111/j.1460-9568.2010.07559.x
Publikováno v:
Antioxidants & Redox Signaling. 11:2655-2671
Reactive oxygen species (ROS) were seen as destructive molecules, but recently, they have been shown also to act as second messengers in varying intracellular signaling pathways. This review concentrates on hydrogen peroxide (H2O2), as it is a more s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34434a71da0a4b42e982228984f5bca
https://doi.org/10.1089/ars.2009.2728
https://doi.org/10.1089/ars.2009.2728
Autor:
Gillian Groeger, Deborah Wallace, Francesca Doonan, Nuria Sanvicens, Thomas G. Cotter, Ashley Mackey
Publikováno v:
Cell Death & Differentiation. 15:1291-1303
Reactive oxygen species have been implicated in processes involving cellular damage and subsequent cell death, especially in organs such as the eye that are constantly exposed to excitatory signals. However, recent studies have shown that oxidant spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66adcc599317d60a660ec6a6e11b20f
https://doi.org/10.1038/cdd.2008.43
https://doi.org/10.1038/cdd.2008.43
Autor:
Gillian Groeger, Catherine D. Nobes
Publikováno v:
Biochemical Journal. 404:23-29
Cell repulsion responses to Eph receptor activation are linked to rapid actin cytoskeletal reorganizations, which in turn are partially mediated by Rho–ROCK (Rho kinase) signalling, driving actomyosin contractility. In the present study, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17c500a589bb04e26e49307bbb2931d
https://doi.org/10.1042/bj20070146
https://doi.org/10.1042/bj20070146
Publikováno v:
Canadian Journal of Zoology. 83:274-279
For many organisms vision is of fundamental importance to many aspects of their lives. Here we present the first study to examine the effects of ontogeny and light intensity on the vision of a cephalopod. We measured the visual acuity of four size cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a08f83e869ad7b545da33be5f82e38e
https://doi.org/10.1139/z05-011
https://doi.org/10.1139/z05-011
Publikováno v:
Journal of Biological Chemistry. 276:23986-23991
The interaction of soluble forms of the human cation-independent insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-IIR) with IGFs and mannosylated ligands was analyzed in real time. IGF-IIR proteins containing domains 1-15, 10-13, 11-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf8f4271f1d66128dfceabf3a7a89438
https://doi.org/10.1074/jbc.m100700200
https://doi.org/10.1074/jbc.m100700200
Publikováno v:
Antioxidantsredox signaling. 19(15)
Once the thought of as unwanted byproducts of cellular respiration in eukaryotes, reactive oxygen species (ROS) have been shown to facilitate essential physiological roles. It is now understood that ROS are critical mediators of intracellular signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fe75ecbca1017c6c2738be8fd43e13
https://pubmed.ncbi.nlm.nih.gov/23198948
https://pubmed.ncbi.nlm.nih.gov/23198948
Publikováno v:
Experimental cell research. 318(11)
There is an urgent need for therapies for retinal diseases; retinitis pigmentosa sufferers have no treatment options available and those targeted at other retinopathies have shown limited effectiveness. The process of programmed cell death or apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3170d2c05165f9cc085b7558d49a9ffe
https://pubmed.ncbi.nlm.nih.gov/22366479
https://pubmed.ncbi.nlm.nih.gov/22366479