Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Gillespie, Colin S"'
Epidemics are inherently stochastic, and stochastic models provide an appropriate way to describe and analyse such phenomena. Given temporal incidence data consisting of, for example, the number of new infections or removals in a given time window, a
Externí odkaz:
http://arxiv.org/abs/2405.13537
Autor:
Fisher, Holly F., Boys, Richard J., Gillespie, Colin S., Proctor, Carole J., Golightly, Andrew
The presence of protein aggregates in cells is a known feature of many human age-related diseases, such as Huntington's disease. Simulations using fixed parameter values in a model of the dynamic evolution of expanded polyglutamine (PolyQ) proteins i
Externí odkaz:
http://arxiv.org/abs/2009.07594
Most computational approaches to Bayesian experimental design require making posterior calculations repeatedly for a large number of potential designs and/or simulated datasets. This can be expensive and prohibit scaling up these methods to models wi
Externí odkaz:
http://arxiv.org/abs/1904.05703
Stochastic kinetic models are often used to describe complex biological processes. Typically these models are analytically intractable and have unknown parameters which need to be estimated from observed data. Ideally we would have measurements on al
Externí odkaz:
http://arxiv.org/abs/1803.04246
Autor:
Gillespie, Colin S., Boys, Richard J.
Stochastic process models are now commonly used to analyse complex biological, ecological and industrial systems. Increasingly there is a need to deliver accurate estimates of model parameters and assess model fit by optimizing the timing of measurem
Externí odkaz:
http://arxiv.org/abs/1803.04254
The challenging problem of conducting fully Bayesian inference for the reaction rate constants governing stochastic kinetic models (SKMs) is considered. Given the challenges underlying this problem, the Markov jump process representation is routinely
Externí odkaz:
http://arxiv.org/abs/1802.07148
Autor:
Gillespie, Colin S
The American Indian war lasted over one hundred years, and is a major event in the history of North America. As expected, since the war commenced in late eighteenth century, casualty records surrounding this conflict contain numerous sources of error
Externí odkaz:
http://arxiv.org/abs/1710.01662
Approaches to Bayesian inference for problems with intractable likelihoods have become increasingly important in recent years. Approximate Bayesian computation (ABC) and "likelihood free" Markov chain Monte Carlo techniques are popular methods for ta
Externí odkaz:
http://arxiv.org/abs/1410.0524
Autor:
Gillespie, Colin S., Golightly, Andrew
Solving the chemical master equation exactly is typically not possible, so instead we must rely on simulation based methods. Unfortunately, drawing exact realisations, results in simulating every reaction that occurs. This will preclude the use of ex
Externí odkaz:
http://arxiv.org/abs/1409.1096
Autor:
Gillespie, Colin S.
Over the last few decades power law distributions have been suggested as forming generative mechanisms in a variety of disparate fields, such as, astrophysics, criminology and database curation. However, fitting these heavy tailed distributions requi
Externí odkaz:
http://arxiv.org/abs/1408.1554