Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets

Autor: Vincent F. M. Segers, Gilles W. De Keulenaer

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 3 (2021)

Abstract The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication between these different cell types, also called paracrine signaling, is essential for normal ca

Externí odkaz: https://doaj.org/article/47283065ded5440fb830a253bab24a48

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

Autor: Vincent F. M. Segers, Dirk L. Brutsaert, Gilles W. De Keulenaer

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides the opportunity of intercellular communication within th

Externí odkaz: https://doaj.org/article/6ac918e3ca844a79ab42ab8c8f1e1fce

Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction

Autor: Stephane Heymans, Kenneth McDonald, Marie-Dominique Devignes, Alexandre Mebazaa, Paolo Marino, Walter Paulus, Giuseppe Ambrosio, Loek van Heerebeek, Jean-Loup Machu, Carsten Tschöpe, Masatake Kobayashi, Alan G. Fraser, Svend Aakhus, Hans-Peter Brunner-La Rocca, Nicolas Girerd, Ricardo Fontes-Carvalho, Kevin Duarte, João Pedro Ferreira, Susan Stienen, Patrick Rossignol, Gilles W. De Keulenaer, Gregoire Preud'homme, Zoltán Papp, Emmanuel Bresso, Riccardo Raddino, Faiez Zannad, Daniela Dobre, Natalia López

Publikováno v: Biomarkers
Biomarkers, Taylor & Francis, 2020, 25 (2), pp.201-211. ⟨10.1080/1354750X.2020.1727015⟩
Biomarkers, 2020, 25 (2), pp.201-211. ⟨10.1080/1354750X.2020.1727015⟩
Stienen, S, Ferreira, J P, Kobayashi, M, Preud'homme, G, Dobre, D, Machu, J-L, Duarte, K, Bresso, E, Devignes, M-D, López, N, Girerd, N, Aakhus, S, Ambrosio, G, Brunner-La Rocca, H-P, Fontes-Carvalho, R, Fraser, A G, van Heerebeek, L, Heymans, S, de Keulenaer, G, Marino, P, McDonald, K, Mebazaa, A, Papp, Z, Raddino, R, Tschöpe, C, Paulus, W J, Zannad, F & Rossignol, P 2020, ' Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction : insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure) ', Biomarkers, vol. 25, no. 2, pp. 201-211 . https://doi.org/10.1080/1354750X.2020.1727015
Biomarkers, 25(2), 201-211. Informa Healthcare
Biomarkers, 25(2), 201-211. Routledge/Taylor & Francis Group
Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals

Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome for which clear evidence of effective therapies is lacking. Understanding which factors determine this heterogeneity may be helped by better phenotyping. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d5ed1bc6819abb6bca12a07878128c
http://www.scopus.com/inward/record.url?scp=85079733476&partnerID=8YFLogxK

Abstract 10935: Identification of Small-Molecule ERBB4 Agonists to Treat Heart Failure

Autor: Eline Feyen, Julie Cools, Jens Van fraeyenhove, Michiel Tubeeckx, Tine Bruyns, Hans De Winter, Dominique Audenaert, Gilles W De Keulenaer, Vincent F Segers

Publikováno v: Circulation. 144

Introduction: Heart failure is a complex syndrome with a poor prognosis. The neuregulin-1 (NRG1)/ERBB4 axis has been shown to be cardioprotective and is a possible target for heart failure therapy. Clinical trials with NRG1 are ongoing, but require i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::885a700568aafe69671beff153b0fa87
https://doi.org/10.1161/circ.144.suppl_1.10935

Epigenetic regulation of intercellular communication in the heart

Autor: Andreas B. Gevaert, Jente R A Boen, Gilles W. De Keulenaer, Emeline M. Van Craenenbroeck, Vincent F.M. Segers

Publikováno v: American journal of physiology: heart and circulatory physiology

The myocardium is a highly structured tissue consisting of different cell types including cardiomyocytes, endothelial cells, fibroblasts, smooth muscle cells, inflammatory cells, and stem cells. Microvascular endothelial cells are the most abundant c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdf5781553d3acb6e67bf16f0e52dc2
https://doi.org/10.1152/ajpheart.00038.2019