Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut

Autor: Maximilian C. Vonolfen, Fenja L. Meyer zu Altenschildesche, Hyuck-Jin Nam, Susanne Brodesser, Akos Gyenis, Jan Buellesbach, Geanette Lam, Carl S. Thummel, Gilles Storelli

Publikováno v: Cell Reports, Vol 43, Iss 9, Pp 114693- (2024)

Summary: Nutrient digestion, absorption, and export must be coordinated in the gut to meet the nutritional needs of the organism. We used the Drosophila intestine to characterize the mechanisms that coordinate the fate of dietary lipids. We identifie

Externí odkaz: https://doaj.org/article/11721f5643b043118c2630a215b08f4e

Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress

Autor: Virginie S. Braman, Joncour P, Michael Frochaux, François Leulier, Claire-Emmanuelle Indelicato, Dali Ma, Bart Deplancke, Maroun Bou-Sleiman, Gilles Storelli, Maria Litovchenko

Publikováno v: iScience
iScience, Elsevier, 2019, 19, pp.436-447. ⟨10.1016/j.isci.2019.07.048⟩
iScience, 2019, 19, pp.436-447. ⟨10.1016/j.isci.2019.07.048⟩
iScience, Vol 19, Iss, Pp 436-447 (2019)

Summary Eukaryotic genomes encode several buffering mechanisms that robustly maintain invariant phenotypic outcome despite fluctuating environmental conditions. Here we show that the Drosophila gut-associated commensals, represented by a single facul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccee5cfe2e2a7e2b9860e836f5fa01f3
https://hal.archives-ouvertes.fr/hal-02389497/document

Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood

Autor: Claudio J. Villanueva, Gilles Storelli, Judith Simcox, Hyuck-Jin Nam, Carl S. Thummel

Publikováno v: Developmental cell. 48(2)

Animals must adjust their metabolism as they progress through development in order to meet the needs of each stage in the life cycle. Here, we show that the dHNF4 nuclear receptor acts at the onset of Drosophila adulthood to direct an essential switc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d67f7983a3e660eedfa0efbe6ddf778
https://pubmed.ncbi.nlm.nih.gov/30695695

Drosophila Perpetuates Nutritional Mutualism by Promoting the Fitness of Its Intestinal Symbiont Lactobacillus plantarum

Autor: Gilles, Storelli, Maura, Strigini, Théodore, Grenier, Loan, Bozonnet, Martin, Schwarzer, Catherine, Daniel, Renata, Matos, François, Leulier

Publikováno v: Cell Metabolism
Cell Metabolism, Elsevier, 2018, 27 (2), pp.362-377. ⟨10.1016/j.cmet.2017.11.011⟩
Cell Metabolism, 2018, 27 (2), pp.362-377. ⟨10.1016/j.cmet.2017.11.011⟩

Summary Facultative animal-bacteria symbioses, which are critical determinants of animal fitness, are largely assumed to be mutualistic. However, whether commensal bacteria benefit from the association has not been rigorously assessed. Using a simple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::33bad5c18566cc9b1775afbce40ba0d6
https://hal.archives-ouvertes.fr/hal-02444094

Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

Autor: Gilles Storelli, Martin Schwarzer, Hana Kozakova, Jennifer Rieusset, Irma Machuca-Gayet, Kassem Makki, Hubert Vidal, François Leulier, Petra Hermanova, Abdelaziz Heddi, Séverine Balmand, Tomas Hudcovic, Dagmar Srutkova, Maria Elena Martino

Publikováno v: Science
Science, American Association for the Advancement of Science, 2016, 351 (6275), pp.854-857. ⟨10.1126/science.aad8588⟩
Science, 2016, 351 (6275), pp.854-857. ⟨10.1126/science.aad8588⟩

Microbiota and infant development Malnutrition in children is a persistent challenge that is not always remedied by improvements in nutrition. This is because a characteristic community of gut microbes seems to mediate some of the pathology. Human gu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b42886b63325c5cbda95dc33d736fc4
https://hal.archives-ouvertes.fr/hal-01449138