5-methylcytosine turnover: Mechanisms and therapeutic implications in cancer

Autor: Marion Turpin, Gilles Salbert

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic mechanisms essential for the control of gene expression and for many other biological processes including genomic imprinting, X chromosome inactivation and

Externí odkaz: https://doaj.org/article/5f35c32f64d441cbaca8f48b770adadc

The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation

Autor: Fabrice Chatonnet, Amandine Pignarre, Aurélien A. Sérandour, Gersende Caron, Stéphane Avner, Nicolas Robert, Alboukadel Kassambara, Audrey Laurent, Maud Bizot, Xabier Agirre, Felipe Prosper, José I. Martin-Subero, Jérôme Moreaux, Thierry Fest, Gilles Salbert

Publikováno v: Haematologica, Vol 105, Iss 3 (2020)

Cell identity relies on the cross-talk between genetics and epigenetics and their impact on gene expression. Oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) is the first step of an active DNA demethylation process occurring ma

Externí odkaz: https://doaj.org/article/3f5c35394af14794af1956e6002ceedc

Coupling Exonuclease Digestion with Selective Chemical Labeling for Base-resolution Mapping of 5-Hydroxymethylcytosine in Genomic DNA

Autor: Aurelien Serandour, Stéphane Avner, Gilles Salbert

Publikováno v: Bio-Protocol, Vol 8, Iss 5 (2018)

This protocol is designed to obtain base-resolution information on the level of 5-hydroxymethylcytosine (5hmC) in CpGs without the need for bisulfite modification. It relies on (i) the capture of hydroxymethylated sequences by a procedure known as �

Externí odkaz: https://doaj.org/article/df9f061f997145ecac5421026f6b8c1c

A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies.

Autor: Jocelyn Plassais, Laetitia Lagoutte, Solenne Correard, Manon Paradis, Eric Guaguère, Benoit Hédan, Alix Pommier, Nadine Botherel, Marie-Christine Cadiergues, Philippe Pilorge, David Silversides, Maud Bizot, Mark Samuels, Carme Arnan, Rory Johnson, Christophe Hitte, Gilles Salbert, Agnès Méreau, Pascale Quignon, Thomas Derrien, Catherine André

Publikováno v: PLoS Genetics, Vol 12, Iss 12, p e1006482 (2016)

Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds are particularly affected by such neuropathies. Clinical signs appear

Externí odkaz: https://doaj.org/article/d603e7affc584f3c8a9338c3dcf23401

ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis

Autor: Anne-Gaëlle Rio, Zi-Ling Liu, Virginie Gandemer, Aurélien A. Sérandour, Benoit Soubise, Marie-Dominique Galibert, Hana Raslova, Jason S. Carroll, Laurent Corcos, Jocelyne Demengeot, Nathalie Douet-Guilbert, Lydie Debaize, Jérémie Rouger-Gaudichon, Marie-Bérengère Troadec, Gilles Salbert, Yan Jiang, David Gilot, Hélène Jakobczyk, Stéphane Avner

Publikováno v: Leukemia
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2021, ⟨10.1038/s41375-021-01409-9⟩
Leukemia, 2022, 36 (2), pp.549-554. ⟨10.1038/s41375-021-01409-9⟩

Funder: Société Française de Biochimie et Biologie Moléculaire ; French Research Ministry
Funder: Cancéropole Grand Ouest ; Région Bretagne ; Société Française d’Hématologie
Funder: Ligue Régionale contre le cancer
ETV6-RU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a182bc8764a055eed499454ec0b13a9a
https://doi.org/10.1038/s41375-021-01409-9