Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gilles Raphy"'
Autor:
Thomas David Pallin, Marc Lemonnier, Stefano Mangani, Martin Everett, Ramakrishna R. Juventhala, Jean Denis Docquier, Maëlle Bayet, Narender Pottabathini, Battu Shankar, Nicolas Sprynski, Ashok Kumar Soodhagani, Gilles Raphy, Jérôme Castandet, Mark William Jones, Juliette Bougnon, Ramesh Pattipati, Alicia Coelho, Clarisse Lozano, Simon Leiris, Neil Jennings, Giulia Cerboni, Manuela Benvenuti, Cecilia Pozzi, David T. Davies, Srinivasu Pothukanuri, Justine Bousquet, Michael C. Cramp, Relangi Sivasubrahmanyam, Filomena De Luca, Magdalena Zalacain
Publikováno v:
'ACS Infectious Diseases ', vol: 5, pages: 131-140 (2019)
ACS Infectious Diseases
ACS Infectious Diseases
The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d21ad6e4e63dacf7d5b80285371e9dc
https://doi.org/10.1021/acsinfecdis.8b00246
https://doi.org/10.1021/acsinfecdis.8b00246
Autor:
Christopher A. Luckhurst, Omar Aziz, Vahri Beaumont, Roland W. Bürli, Perla Breccia, Michel C. Maillard, Alan F. Haughan, Marieke Lamers, Phil Leonard, Kim L. Matthews, Gilles Raphy, Andrew J. Stott, Ignacio Munoz-Sanjuan, Beth Thomas, Michael Wall, Grant Wishart, Dawn Yates, Celia Dominguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
We have identified a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor 22, with500-fold selectivity over class I HDACs (1,2,3) and ∼150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. Dose escalati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc52289ed1bc17170b0a3a38854cb42
https://pubmed.ncbi.nlm.nih.gov/30463802
https://pubmed.ncbi.nlm.nih.gov/30463802
Autor:
Hiroki Wada, Tony Raynham, Rebekah E. Beevers, Jeremy Major, Jess Taylor, Neil Grimster, David W. Walker, Parminder Kaur Ruprah, Svenja Burckhardt, Hannah Fiona Sore, James Nally, Alison Reid, Steven P. Langston, Andrew H. Henry, Helen J. Payne, Yvonne Ferguson, John C Reader, Eva Figueroa, Michael Shaw, Abid Masood, Nawaz Mohammed Khan, Valérie Reader, Lloyd J. Payne, Kerry Jenkins, Stephen Thompson, Ruth Adams, Matthew Stirling, Richard J. Boyce, Adam C. Talbot, Gilles Raphy, Jones Mark, Robert Judkins, James M. Cobb, Justine Y.Q. Lai
Publikováno v:
Medicinal Research Reviews. 25:310-330
This work describes the preparation of approximately 13,000 compounds for rapid identification of hits in high-throughput screening (HTS). These compounds were designed as potential serine/threonine or tyrosine kinase inhibitors. The library consists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c2cfd46838ec84ce2d3ca8b3d9e0bd
https://doi.org/10.1002/med.20026
https://doi.org/10.1002/med.20026
Publikováno v:
Tetrahedron. 51:11815-11830
The optimised synthesis of 17-tetrabenzo[a,c,g,i]fluorenylmethylchloroformate (TbfmocCl) and its use a reagent for the rapid and efficient purification of synthetic polypeptides is reported. Incorporation of the Tbfmoc group onto the N-terminus of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3463ec5a9e392dba4867322eb73cc61
https://doi.org/10.1016/0040-4020(95)00743-r
https://doi.org/10.1016/0040-4020(95)00743-r
Autor:
Gilles Raphy, Thomas Gray, Michael R. Florence, Peter L. Roach, Robert Ramage, Alexander J. Blake
Publikováno v:
ChemInform. 23
A base labile urethane (Bnpeoc) group derived from 2,2-bis(4′-nitrophenyl)ethan-1-ol has been developed as an amine protecting group. This protecting group may be cleaved using the reagents DBN, DBU, DBU/HOAc and piperidine. The preparations of Nα
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a588254683fbec025d46c1fe91ab261
https://doi.org/10.1002/chin.199202276
https://doi.org/10.1002/chin.199202276
Publikováno v:
ChemInform. 27
The optimised synthesis of 17-tetrabenzo[a,c,g,i]fluorenylmethylchloroformate (TbfmocCl) and its use a reagent for the rapid and efficient purification of synthetic polypeptides is reported. Incorporation of the Tbfmoc group onto the N-terminus of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad84c1a3bd0f152d53bafe26f2dc5a26
https://doi.org/10.1002/chin.199609225
https://doi.org/10.1002/chin.199609225
Autor:
Gilles Raphy, Robert Ramage
Publikováno v:
Tetrahedron Letters. 33:385-388
A new Nα-amino protecting group (Tbfmoc) has been designed to allow selective adsorption to porous graphitised carbon, thus allowing facile separation of Nα-acetylated truncated peptides generated as impurities in solid phase peptide synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b9ffe323483ab7dd373c1292ce4f072
https://doi.org/10.1016/s0040-4039(00)74138-4
https://doi.org/10.1016/s0040-4039(00)74138-4
Autor:
Michael R. Florence, Peter L. Roach, Alexander J. Blake, Thomas Gray, Robert Ramage, Gilles Raphy
Publikováno v:
Tetrahedron. 47:8001-8024
A base labile urethane (Bnpeoc) group derived from 2,2-bis(4′-nitrophenyl)ethan-1-ol has been developed as an amine protecting group. This protecting group may be cleaved using the reagents DBN, DBU, DBU/HOAc and piperidine. The preparations of Nα
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92841d4d792775fc53447c2d6e096d62
https://doi.org/10.1016/s0040-4020(01)81953-0
https://doi.org/10.1016/s0040-4020(01)81953-0
Autor:
Christopher James Lock, David Alan Owen, Robert John Watson, Daniel Rees Allen, Helen L. Birch, Louise A. Jopling, Roland L. Knight, Gilles Raphy, Sophie Caroline Williams, Frances C.A. Galvin, Johannes W.G. Meissner, Gayle A. Chapman
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
The synthesis and biological evaluation of a novel series of 2-aminoquinoline substituted piperidines and tropanes incorporating a homotropene moiety is herein described. The series exhibits potent antagonism of the CXCR3 receptor and superior physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e418a4a1be65f386c4fdf59bafda8a7
https://pubmed.ncbi.nlm.nih.gov/18068363
https://pubmed.ncbi.nlm.nih.gov/18068363