Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Autor: Olivia Goethals, Suzanne J. F. Kaptein, Bart Kesteleyn, Jean-François Bonfanti, Liesbeth Van Wesenbeeck, Dorothée Bardiot, Ernst J. Verschoor, Babs E. Verstrepen, Zahra Fagrouch, J. Robert Putnak, Dominik Kiemel, Oliver Ackaert, Roel Straetemans, Sophie Lachau-Durand, Peggy Geluykens, Marjolein Crabbe, Kim Thys, Bart Stoops, Oliver Lenz, Lotke Tambuyzer, Sandra De Meyer, Kai Dallmeier, Michael K. McCracken, Gregory D. Gromowski, Wiriya Rutvisuttinunt, Richard G. Jarman, Nicos Karasavvas, Franck Touret, Gilles Querat, Xavier de Lamballerie, Laurent Chatel-Chaix, Gregg N. Milligan, David W. C. Beasley, Nigel Bourne, Alan D. T. Barrett, Arnaud Marchand, Tim H. M. Jonckers, Pierre Raboisson, Kenny Simmen, Patrick Chaltin, Ralf Bartenschlager, Willy M. Bogers, Johan Neyts, Marnix Van Loock

Publikováno v: Nature. 615:678-686

Dengue is a major health threat and the number of symptomatic infections caused by the four dengue serotypes is estimated to be 96 million1 with annually around 10,000 deaths2. However, no antiviral drugs are available for the treatment or prophylaxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8c0a4183f19bf33ac0d110d21b457f
https://doi.org/10.1038/s41586-023-05790-6

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

Autor: Giuseppe Manfroni, Andrea Astolfi, Serena Massari, Stefano Sabatini, Delia Tarantino, Violetta Cecchetti, Gilles Querat, Maria Letizia Barreca, Eloise Mastrangelo, Mario Milani, Rolando Cannalire, Oriana Tabarrini

Publikováno v: European journal of medicinal chemistry (Online) 143 (2018): 1667–1676. doi:10.1016/j.ejmech.2017.10.064
info:cnr-pdr/source/autori:Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V/titolo:Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase/doi:10.1016%2Fj.ejmech.2017.10.064/rivista:European journal of medicinal chemistry (Online)/anno:2018/pagina_da:1667/pagina_a:1676/intervallo_pagine:1667–1676/volume:143

Over recent years, many RNA viruses have been “re-discovered”, including life-threatening flaviviruses, such as Dengue, Zika, and several encephalitis viruses. Since no specific inhibitors are currently available to treat these infections, there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4156ceeaef04b327e11028c150e3873
https://doi.org/10.1016/j.ejmech.2017.10.064

Novel class of chikungunya virus small molecule inhibitors that targets the viral capping machinery

Autor: Leen Delang, Bruno Coutard, Patrick Chaltin, Martijn J. van Hemert, Julia Moesslacher, Gilles Querat, Etienne Decroly, Kristina Kovacikova, Arnaud Marchand, Ali Tas, Pieter Leyssen, Kim Donckers, Rana Abdelnabi, Changqing Li, Johan Neyts, Verena Battisti, Gerhard Puerstinger, Thierry Langer

Publikováno v: Antimicrobial Agents and Chemotherapy, 64(7). AMER SOC MICROBIOLOGY
Antimicrob Agents Chemother
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2020, 64 (7), ⟨10.1128/AAC.00649-20⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2020, 64 (7), ⟨10.1128/AAC.00649-20⟩

International audience; Despite the worldwide reemergence of the chikungunya virus (CHIKV) and the high morbidity associated with CHIKV infections, there is no approved vaccine or antiviral treatment available. Here, we aimed to identify the target o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c811d9c41a63b3b011bc9677686c6e8
http://hdl.handle.net/1887/3184140

A novel class of small molecule inhibitors targeting the chikungunya virus capping machinery with a high barrier to resistance

Autor: Thierry Langer, Bruno Coutard, Martijn J. van Hemert, Gilles Querat, Gerhard Puerstinger, Johan Neyts, Arnaud Marchand, Leen Delang, Patrick Chaltin, Pieter Leyssen, Kristina Kovacikova, Julia Kirchebner, Rana Abdelnabi

Publikováno v: Access Microbiology. 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf9457d71ec6f7d4f924fbe9c79643a8
https://doi.org/10.1099/acmi.imav2019.po0012

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions

Autor: Rolando Cannalire, Mario Milani, Giuseppe Manfroni, Géraldine Piorkowski, Serena Massari, Violetta Cecchetti, Maria Letizia Barreca, Tommaso Felicetti, Gilles Querat, Delia Tarantino, Tea Carletti, Alessandro Marcello, Stefano Sabatini, Oriana Tabarrini, Eloise Mastrangelo

Publikováno v: Antiviral Research
Antiviral Research, 2019, 167, pp.6-12. ⟨10.1016/j.antiviral.2019.03.004⟩
Antiviral research
167 (2019): 6–12. doi:10.1016/j.antiviral.2019.03.004
info:cnr-pdr/source/autori:Cannalire R, Tarantino D, Piorkowski G, Carletti T, Massari S, Felicetti T, Barreca ML, Sabatini S, Tabarrini O, Marcello A, Milani M, Cecchetti V, Mastrangelo E, Manfroni G, Querat G/titolo:Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions/doi:10.1016%2Fj.antiviral.2019.03.004/rivista:Antiviral research (Print)/anno:2019/pagina_da:6/pagina_a:12/intervallo_pagine:6–12/volume:167
Antiviral Research, Elsevier Masson, 2019, 167, pp.6-12. ⟨10.1016/j.antiviral.2019.03.004⟩

We report the design, synthesis, and biological evaluation of a class of 1H-pyrido[2,1-b][1,3]benzothiazol-1-ones originated from compound 1, previously identified as anti-flavivirus agent. Some of the new compounds showed activity in low ?M range wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726cb8d92b0c4847bc9dc7a3cac2b6c2
http://hdl.handle.net/11588/764687