Výsledky vyhledávání - "Gilles Ponchel"

Akademický článek

A physiologically-based pharmacokinetic model for predicting doxorubicin disposition in multiple tissue levels and quantitative toxicity assessment

Autor: Fang-Ching Chao, Eloísa Berbel Manaia, Gilles Ponchel, Chien-Ming Hsieh

Publikováno v: Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115636- (2023)

Doxorubicin is a widely-used chemotherapeutic drug, however its high toxicity poses a significant challenge for its clinical use. To address this issue, a physiologically-based pharmacokinetic (PBPK) model was implemented to quantitatively assess dox

Externí odkaz: https://doaj.org/article/39991fef80c34e1191d6c48f6f7edb3f

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Akademický článek

Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder

Autor: Raul Diaz-Salmeron, Balthazar Toussaint, Catherine Cailleau, Gilles Ponchel, Kawthar Bouchemal

Publikováno v: Advanced NanoBiomed Research, Vol 2, Iss 5, Pp n/a-n/a (2022)

Intravesical instillation allows for direct exposure of the urothelium to a drug. However, the therapeutic efficacy is often limited by the rapid elimination of the drug from the bladder. In this investigation, it is hypothesized that the morphology

Externí odkaz: https://doaj.org/article/720531a436c544c0ab1f907acca7df58

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Akademický článek

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques.

Autor: Nathalie Dereuddre-Bosquet, Laurence Morellato-Castillo, Joachim Brouwers, Patrick Augustijns, Kawthar Bouchemal, Gilles Ponchel, Oscar H P Ramos, Carolina Herrera, Martha Stefanidou, Robin Shattock, Leo Heyndrickx, Guido Vanham, Pascal Kessler, Roger Le Grand, Loïc Martin

Publikováno v: PLoS Pathogens, Vol 8, Iss 12, p e1003071 (2012)

In complement to an effective vaccine, development of potent anti-HIV microbicides remains an important priority. We have previously shown that the miniCD4 M48U1, a functional mimetic of sCD4 presented on a 27 amino-acid stable scaffold, inhibits a b

Externí odkaz: https://doaj.org/article/0589cd679b414475b3cbd112e8baf239

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Nanoparticles facing the gut barrier: retention or mucosal absorption? Mechanisms and dependency to nanoparticle characteristics

Autor: Christine Vauthier, Christelle Zandanel, Magali Noiray, Gilles Ponchel

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2021, pp.121147. ⟨10.1016/j.ijpharm.2021.121147⟩

International audience; A better knowledge on influence of nanomedicine characteristics on their biological efficacy and safety is expected to accelerate their clinical translation. This work aimed understanding of the oral fate of polymer-based nano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aca58b771f70d58a4ca92726b4e611
https://hal.archives-ouvertes.fr/hal-03372832

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Cytotoxicidad de nanopartículas a base de poli (L-glutamato de g-bencilo) cuando es expresada en molaridad

Autor: An Young Sarahi Taylor-Castillo, Gilles Ponchel, María Elisa Martínez-Barbosa

Publikováno v: Biotecnia. 21:145-154

En este trabajo se propone un método para calcular la concentración molar en base al número de nanopartículas poliméricas (Mnps) contenidas en una suspensión coloidal para ser utilizada en estudios de MTT, permitiendo comparar el impacto del n�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8fe06fa1ddeb2b1d51f9a46a8e8cfb6
https://doi.org/10.18633/biotecnia.v21i2.940

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Role of the interactions of soft hyaluronan nanomaterials with CD44 and supported bilayer membranes in the cellular uptake

Autor: Jean-Philippe Michel, Evelyne Gout, Raul Diaz-Salmeron, Romain R. Vivès, Hicheme Hadji, Gilles Ponchel, Kawthar Bouchemal

Publikováno v: Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces, Elsevier, 2021, 205, pp.111916. ⟨10.1016/j.colsurfb.2021.111916⟩
Colloids and Surfaces B: Biointerfaces, 2021, 205, pp.111916. ⟨10.1016/j.colsurfb.2021.111916⟩

International audience; Increasing valence by acting on nanomaterial morphology can enhance the ability of a ligand to specifically bind to targeted cells. Herein, we investigated cell internalization of soft hyaluronic acid (HA) nanoplatelets (NPs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cf7ae76497d19a35d8bee57bd56b69
https://pubmed.ncbi.nlm.nih.gov/34146785

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Characterization and in vitro evaluation of a vaginal gel containing Lactobacillus crispatus for the prevention of gonorrhea

Autor: H. Faye-Kette, A.A.S. Aka Any-Grah, Nicolas Huang, A. Yeo, Armand Koffi, S. Bouttier, S. Villebrun, Sandrine Geiger, Valérie Nicolas, Florence Agnely, K.C. N'Guessan Gnaman, Gilles Ponchel

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2020, 588, pp.119733. ⟨10.1016/j.ijpharm.2020.119733⟩
International Journal of Pharmaceutics, 2020, 588, pp.119733. ⟨10.1016/j.ijpharm.2020.119733⟩

International audience; The increasing resistance of Neisseria gonorrhoeae to any current antibiotic treatment and the difficulties associated with the use of prevention means such as condom urge the need for alternative methods to prevent this sexua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a641c2ee01003a6e5dc15207e7e7b345
https://pubmed.ncbi.nlm.nih.gov/32768529

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Hierarchical supramolecular platelets from hydrophobically-modified polysaccharides and α-cyclodextrin: Effect of hydrophobization and α-cyclodextrin concentration on platelet formation

Autor: Jean-François Gallard, Kawthar Bouchemal, Gilles Ponchel, Raul Diaz-Salmeron

Publikováno v: International Journal of Pharmaceutics. 548:227-236

Micro- and nano-platelets are a group of particles with typical flat surfaces and hexagonal shape. They are obtained by hierarchical self-assembly in water of α-cyclodextrin and polysaccharides hydrophobically-modified with alkyl chains. It is expec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea363785759c8307df3cd2f0070640b
https://doi.org/10.1016/j.ijpharm.2018.06.061

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Phase solubility studies and anti-Trichomonas vaginalis activity evaluations of metronidazole and methylated β-cyclodextrin complexes: Comparison of CRYSMEB and RAMEB

Autor: Philippe M. Loiseau, Gilles Ponchel, Christian Bories, Kawthar Bouchemal, Sophia Malli

Publikováno v: Experimental Parasitology. 189:72-75

Metronidazole (MTZ) is a 5-nitroimidazole drug used for the treatment of Trichomonas vaginalis parasitic infection. Aqueous formulations containing MTZ are restricted because apparent solubility in water of this drug is low. In this context, two meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07247bc5f3afbd8ad369497847ae8a97
https://doi.org/10.1016/j.exppara.2018.04.019

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Shape stability of ellipsoidal nanomaterials prepared by physical deformation

Autor: Zeeshan Ahmed, Gilles Ponchel, Kawthar Bouchemal

Publikováno v: International Journal of Pharmaceutics. 609:121178

The nonspherical shape of nanomaterials (NMs) represents a key attribute for controlling their biological behaviors. Analyzing shape stability over time represents a significant concern because nonspherical NMs are likely to rearrange into a thermody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8645557139568005ac243849a3c4cc05
https://doi.org/10.1016/j.ijpharm.2021.121178

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