Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Gilles P van Wezel"'
Autor:
Alexander M Kloosterman, Peter Cimermancic, Somayah S Elsayed, Chao Du, Michalis Hadjithomas, Mohamed S Donia, Michael A Fischbach, Gilles P van Wezel, Marnix H Medema
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001026 (2020)
Microbial natural products constitute a wide variety of chemical compounds, many which can have antibiotic, antiviral, or anticancer properties that make them interesting for clinical purposes. Natural product classes include polyketides (PKs), nonri
Externí odkaz:
https://doaj.org/article/37a2f5ceef8e46f8a72e0714fee61104
Autor:
Jo-Anne Verschoor, Martijn R. J. Croese, Sven E. Lakemeier, Annemiek Mugge, Charlotte M. C. Burgers, Paolo Innocenti, Joost Willemse, Marjolein E. Crooijmans, Gilles P. van Wezel, Arthur F. J. Ram, Johannes H. de Winde
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract The rising use of plastic results in an appalling amount of waste which is scattered into the environment. One of these plastics is PET which is mainly used for bottles. We have identified and characterized an esterase from Streptomyces, ann
Externí odkaz:
https://doaj.org/article/d1c9ae063f6341508cb5cbdb026d08f3
Autor:
Isabel Nuñez Santiago, Nataliia V. Machushynets, Marija Mladic, Doris A. van Bergeijk, Somayah S. Elsayed, Thomas Hankemeier, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast majority has not yet been discovered, among others because the hidden chemical space is obscured by previously identified (and typically abunda
Externí odkaz:
https://doaj.org/article/0c87ac983fb441bc8d63c0baaabb8440
Autor:
Magdalena A Świątek-Połatyńska, Giselda Bucca, Emma Laing, Jacob Gubbens, Fritz Titgemeyer, Colin P Smith, Sébastien Rigali, Gilles P van Wezel
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122479 (2015)
Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and secondary metabolism are closely entwined in streptomycetes. Here we show that DNA recognit
Externí odkaz:
https://doaj.org/article/72837298f25f4cbe9ac070a4ea6957c4
Autor:
Dennis Claessen, Gilles P van Wezel
Publikováno v:
eLife, Vol 3 (2014)
Bacteria that grow and proliferate despite having been stripped of their cell wall may provide insights into how primordial cells could have propagated billions of years ago.
Externí odkaz:
https://doaj.org/article/4d1562c9493f42ffa462e993cc01d655
Autor:
Somayah S. Elsayed, Helga U. van der Heul, Xiansha Xiao, Aleksi Nuutila, Laura R. Baars, Changsheng Wu, Mikko Metsä-Ketelä, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Angucyclines are type II polyketide natural products, often characterized by unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone. While the enzymes involved in B-ring cleavage have been extensively s
Externí odkaz:
https://doaj.org/article/552e4cdb804544a5861a5f3671f524ed
Autor:
Qingping Xu, Gilles P van Wezel, Hsiu-Ju Chiu, Lukasz Jaroszewski, Heath E Klock, Mark W Knuth, Mitchell D Miller, Scott A Lesley, Adam Godzik, Marc-André Elsliger, Ashley M Deacon, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41359 (2012)
Actinomycetes are important bacterial sources of antibiotics and other secondary metabolites. Many antibiotic gene clusters are controlled by pathway-specific activators that act in response to growth conditions. Here we present the crystal structure
Externí odkaz:
https://doaj.org/article/22bb6da506f943bd8bc2e65b7fefc3c6
Autor:
Joost Willemse, Gilles P van Wezel
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4242 (2009)
Imaging of low abundance proteins in time and space by fluorescence microscopy is typically hampered by host-cell autofluorescence. Streptomycetes are an important model system for the study of bacterial development, and undergo multiple synchronous
Externí odkaz:
https://doaj.org/article/b6cb0bce7b524cb79acf0b8d4ccd347a
Autor:
Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S. peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of prod
Externí odkaz:
https://doaj.org/article/4df9c2d97b6a46d0a40d7261af1249f7
Autor:
Jack Jansma, Nicola U. Thome, Markus Schwalbe, Anastasia Chrysovalantou Chatziioannou, Somayah S. Elsayed, Gilles P. van Wezel, Pieter van den Abbeele, Saskia van Hemert, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often not w
Externí odkaz:
https://doaj.org/article/aefc9eaf089d4395beb16aea36d020a3