Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Gilles P, van Wezel"'
Autor:
Jo-Anne Verschoor, Martijn R. J. Croese, Sven E. Lakemeier, Annemiek Mugge, Charlotte M. C. Burgers, Paolo Innocenti, Joost Willemse, Marjolein E. Crooijmans, Gilles P. van Wezel, Arthur F. J. Ram, Johannes H. de Winde
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract The rising use of plastic results in an appalling amount of waste which is scattered into the environment. One of these plastics is PET which is mainly used for bottles. We have identified and characterized an esterase from Streptomyces, ann
Externí odkaz:
https://doaj.org/article/d1c9ae063f6341508cb5cbdb026d08f3
Autor:
Isabel Nuñez Santiago, Nataliia V. Machushynets, Marija Mladic, Doris A. van Bergeijk, Somayah S. Elsayed, Thomas Hankemeier, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast majority has not yet been discovered, among others because the hidden chemical space is obscured by previously identified (and typically abunda
Externí odkaz:
https://doaj.org/article/0c87ac983fb441bc8d63c0baaabb8440
Autor:
Somayah S. Elsayed, Helga U. van der Heul, Xiansha Xiao, Aleksi Nuutila, Laura R. Baars, Changsheng Wu, Mikko Metsä-Ketelä, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Angucyclines are type II polyketide natural products, often characterized by unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone. While the enzymes involved in B-ring cleavage have been extensively s
Externí odkaz:
https://doaj.org/article/552e4cdb804544a5861a5f3671f524ed
Autor:
Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S. peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of prod
Externí odkaz:
https://doaj.org/article/4df9c2d97b6a46d0a40d7261af1249f7
Autor:
Jack Jansma, Nicola U. Thome, Markus Schwalbe, Anastasia Chrysovalantou Chatziioannou, Somayah S. Elsayed, Gilles P. van Wezel, Pieter van den Abbeele, Saskia van Hemert, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often not w
Externí odkaz:
https://doaj.org/article/aefc9eaf089d4395beb16aea36d020a3
Autor:
Renée Kapteijn, Shraddha Shitut, Dennis Aschmann, Le Zhang, Marit de Beer, Deniz Daviran, Rona Roverts, Anat Akiva, Gilles P. van Wezel, Alexander Kros, Dennis Claessen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Horizontal gene transfer in bacteria can occur through mechanisms such as conjugation, transduction and transformation, which facilitate the passage of DNA across the cell wall. Here, Kapteijn et al. show that cell wall-deficient bacteria can take up
Externí odkaz:
https://doaj.org/article/3570792ec0184d2f925e6e725d5003ee
Autor:
Doris A. van Bergeijk, Somayah S. Elsayed, Chao Du, Isabel Nuñez Santiago, Anna M. Roseboom, Le Zhang, Victor J. Carrión, Herman P. Spaink, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-12 (2022)
The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential. Here, the authors show t
Externí odkaz:
https://doaj.org/article/38cafff306da48aa90a4c69594586c68
Autor:
Nataliia V. Machushynets, Somayah S. Elsayed, Chao Du, Maxime A. Siegler, Mercedes de la Cruz, Olga Genilloud, Thomas Hankemeier, Gilles P. van Wezel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging fruit has been discovered, it is predicted that less than 5% of the chemical space
Externí odkaz:
https://doaj.org/article/936e287858154edda7e76a3907273f6b
Autor:
Chao Du, Joost Willemse, Amanda M. Erkelens, Victor J. Carrion, Remus T. Dame, Gilles P. van Wezel
Publikováno v:
mSystems, Vol 7, Iss 3 (2022)
ABSTRACT Bacterial chromosome structure is, to a great extent, organized by a diverse group of proteins collectively referred to as nucleoid-associated proteins (NAPs). Many NAPs have been well studied in Streptomyces, including Lsr2, HupA, HupS, and
Externí odkaz:
https://doaj.org/article/bd447d8e4db64f64ac5a5a4cf038baa5
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Peptidoglycan is a major constituent of the bacterial cell wall and an important determinant for providing protection to cells. In addition to peptidoglycan, many bacteria synthesize other glycans that become part of the cell wall. Streptomy
Externí odkaz:
https://doaj.org/article/25de8d6e647f45d284295f18281d4edb