Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Gilles Lemaitre"'
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Akademický článek
Generation of heterozygous and homozygous NF1 lines from human-induced pluripotent stem cells using CRISPR/Cas9 to investigate bone defects associated with neurofibromatosis type 1
Autor: Annabelle Darle, Thibault Mahiet, Déborah Aubin, Manon Doyen, Lina El Kassar, Béatrice Parfait, Gilles Lemaitre, Christine Baldeschi, Jennifer Allouche, Nathalie Holic
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders caused by heterozygous germline NF1 mutations. NF1 affects many systems, including the skeletal system. To date, no curative therapies are available for skeletal manifestation
Externí odkaz: https://doaj.org/article/e3866548f6d2478d899ba5a586aec4b7
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2
Akademický článek
Clinical Grade Human Pluripotent Stem Cell-Derived Engineered Skin Substitutes Promote Keratinocytes Wound Closure In Vitro
Autor: Sophie Domingues, Annabelle Darle, Yolande Masson, Manoubia Saidani, Emilie Lagoutte, Ana Bejanariu, Julien Coutier, Raif Eren Ayata, Marielle Bouschbacher, Marc Peschanski, Gilles Lemaitre, Christine Baldeschi
Publikováno v: Cells, Vol 11, Iss 7, p 1151 (2022)
Chronic wounds, such as leg ulcers associated with sickle cell disease, occur as a consequence of a prolonged inflammatory phase during the healing process. They are extremely hard to heal and persist as a significant health care problem due to the a
Externí odkaz: https://doaj.org/article/082881e873454491aeba570f1d272f20
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3
Generating Functional and Highly Proliferative Melanocytes Derived from Human Pluripotent Stem Cells: A Promising Tool for Biotherapeutic Approaches to Treat Skin Pigmentation Disorders
Autor: Manoubia Saidani, Annabelle Darle, Margot Jarrige, Hélène Polveche, Lina El Kassar, Séverine Julié, Sandrine Bessou-Touya, Nathalie Holic, Gilles Lemaitre, Cécile Martinat, Christine Baldeschi, Jennifer Allouche
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6398
Melanocytes are essential for skin homeostasis and protection, and their loss or misfunction leads to a wide spectrum of diseases. Cell therapy utilizing autologous melanocytes has been used for years as an adjunct treatment for hypopigmentary disord
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a36ec13029e61256717e21ab955b4a
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7
Human-Induced Pluripotent Stem Cell‒Derived Keratinocytes, a Useful Model to Identify and Explore the Pathological Phenotype of Epidermolysis Bullosa Simplex
Autor: Julien Coutier, Manon Bonnette, Sabrina Martineau, Aurélie Mercadier, Sophie Domingues, Manoubia Saidani, Margot Jarrige, Hélène Polveche, Annabelle Darle, Nathalie Holic, Smail Hadj-Rabia, Christine Bodemer, Gilles Lemaitre, Cécile Martinat, Christine Baldeschi
Publikováno v: Journal of Investigative Dermatology. 142:2695-2705.e11
Epidermolysis bullosa simplex (EBS), an autosomal dominant skin disorder, is characterized by skin fragility. Genetically, the majority of cases are related to missense sequence variations in two keratin genes K5 or K14, leading to cytolysis of basal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ce6893c5d328708e3a14ffb2d1afc7
https://doi.org/10.1016/j.jid.2022.04.009
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8
KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes
Autor: Paul-Henri Romeo, Michèle T. Martin, Jean-François Deleuze, Nicolas O. Fortunel, Sophie Domingues, Sophie Cavallero, Julien Coutier, Loubna Chadli, Frédéric Auvré, Emmanuelle Bouissou-Cadio, Gilles Lemaitre, Pierre Vaigot
Publikováno v: Nature biomedical engineering. 3(12)
Expanded autologous skin keratinocytes are currently used in cutaneous cell therapy, and embryonic-stem-cell-derived keratinocytes could become a complementary alternative. Regardless of keratinocyte provenance, for efficient therapy it is necessary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf216dd340180f782b67d12a61173ca9
https://pubmed.ncbi.nlm.nih.gov/31636412
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9
In vitro modeling of hyperpigmentation associated to neurofibromatosis type 1 using melanocytes derived from human embryonic stem cells
Autor: Floriane Gilles-Marsens, Anand Patwardhan, Jennifer Allouche, Christine Baldeschi, Yolande Masson, Manoubia Saidani, Sophie Domingues, Cédric Delevoye, N. Bellon, Gilles Lemaitre, Laure Stanchina-Chatrousse, Marc Peschanski, Cécile Martinat, Xavier Nissan
Publikováno v: Proceedings of the National Academy of Sciences. 112:9034-9039
"Café-au-lait" macules (CALMs) and overall skin hyperpigmentation are early hallmarks of neurofibromatosis type 1 (NF1). One of the most frequent monogenic diseases, NF1 has subsequently been characterized with numerous benign Schwann cell-derived t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b19e8d738c0695d2796d8185d81bf87
https://doi.org/10.1073/pnas.1501032112
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10
Differentiation of nonhuman primate pluripotent stem cells into functional keratinocytes
Autor: Cécile Martinat, Yolande Masson, Jennifer Allouche, Sophie Domingues, Aurore Marteyn, Gilles Lemaitre, Christine Baldeschi, Marc Peschanski, Anselme L. Perrier
Publikováno v: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-7 (2017)
Background Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine. To date, the safety of the graft would be the major unmet deal in order to implement long-term skin gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d8bf286c5234c99172620b71c1113f
https://doi.org/10.1186/s13287-017-0741-9
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