Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Gilles Labbe"'
Autor:
Raymond Pieters, Klaus Gjervig Jensen, Philip G. Hewitt, Jan Snoeys, Bob van de Water, B. Kevin Park, Ursula Klingmüller, André Guillouzo, Ian M. Copple, Dominic P. Williams, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Satu Juhila, Eric A.G. Blomme, Magnus Ingelman-Sundberg, Dean J. Naisbitt, Gilles Labbe, Amy E. Chadwick, Christopher E. Goldring, Helga H.J. Gerets, Richard J. Weaver
Publikováno v:
Nature Reviews Drug Discovery
Nature Reviews Drug Discovery, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
Nature Reviews Drug Discovery, Nature Publishing Group, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
NATURE REVIEWS DRUG DISCOVERY
Nature Reviews Drug Discovery, 19, 131-148
Nature Reviews Drug Discovery, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
Nature Reviews Drug Discovery, Nature Publishing Group, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
NATURE REVIEWS DRUG DISCOVERY
Nature Reviews Drug Discovery, 19, 131-148
International audience; Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of
Autor:
Mikael Persson, Helga H.J. Gerets, Klaus Gjervig Jensen, Natalie Mesens, Jan Snoeys, B. Kevin Park, Tracy Walker, James L. Stevens, Catherine J. Betts, Gilles Labbe, Monday O. Ogese, Richard J. Weaver, Philip G. Hewitt, Michael J. Liguori, Eric A.G. Blomme, Satu Juhila
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 13:767-782
Introduction: The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue
Autor:
Mohamed Elmasry, Cerys A. Lovatt, Julie C. Holder, Christopher E. Goldring, Hélène Aerts, Christopher A. Schofield, Helga H.J. Gerets, Delphine Hoët, Richard J. Weaver, Eliane Alexandre, Lysiane Richert, Gilles Labbe, Esther Johann, Sébastien Anthérieu, Martina Dorau, Magnus Ingelman-Sundberg, B. Kevin Park, Neil R. Kitteringham, Robert P. Jones, Simone H. Stahl, Philip G. Hewitt, Rowena Sison-Young, Volker M. Lauschke
Publikováno v:
Archives of Toxicology
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether cell models currently used in safety assessment (HepG2, HepaRG, Upcyte and primary human h
Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells
Autor:
Gilles Labbe, Anne Lombès, Simon Bucher, Bernard Fromenty, Karima Begriche, Delphine Hoët, Dounia Le Guillou
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, 2018, 365 (3), pp.711-726. ⟨10.1124/jpet.117.246751⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2018, 365 (3), pp.711-726. ⟨10.1124/jpet.117.246751⟩
Journal of Pharmacology and Experimental Therapeutics, 2018, 365 (3), pp.711-726. 〈10.1124/jpet.117.246751〉
Journal of Pharmacology and Experimental Therapeutics, 2018, 365 (3), pp.711-726. ⟨10.1124/jpet.117.246751⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2018, 365 (3), pp.711-726. ⟨10.1124/jpet.117.246751⟩
Journal of Pharmacology and Experimental Therapeutics, 2018, 365 (3), pp.711-726. 〈10.1124/jpet.117.246751〉
International audience; Although mitochondriotoxicity plays a major role in drug-induced hepatotoxicity, alteration of mitochondrial DNA (mtDNA) homeostasis has been described only with a few drugs. Because it requires long drug exposure, this mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edeb3b4f151782df0093d2f84525fe46
https://univ-rennes.hal.science/hal-01808097
https://univ-rennes.hal.science/hal-01808097
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1641
Mitochondrial dysfunction is a major mechanism whereby drugs can induce liver injury and other serious side effects, such as lactic acidosis and rhabdomyolysis, in some patients. Several in vitro and in vivo investigations can be performed in order t
Autor:
Richard J, Weaver, Catherine, Betts, Eric A G, Blomme, Helga H J, Gerets, Klaus, Gjervig Jensen, Philip G, Hewitt, Satu, Juhila, Gilles, Labbe, Michael J, Liguori, Natalie, Mesens, Monday O, Ogese, Mikael, Persson, Jan, Snoeys, James L, Stevens, Tracy, Walker, B Kevin, Park
Publikováno v:
Expert opinion on drug metabolismtoxicology. 13(7)
The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue for drug deve
Autor:
Donna Dambach, Frederic Moulin, Okechukwu Ukairo, Richard J. Weaver, Franck A. Atienzar, Gilles Labbe, Philip Hewitt, J. Gerry Kenna, Eric A.G. Blomme, Minjun Chen, Yvonne Will, Laura Suter-Dick, Adrian Roth, Francois Pognan
Publikováno v:
BioMed Research International, Vol 2016 (2016)
BioMed Research International
BioMed Research International
Drug-induced liver injury (DILI) is a major cause of late-stage clinical drug attrition, market withdrawal, black-box warnings, and acute liver failure. Consequently, it has been an area of focus for toxicologists and clinicians for several decades.
Autor:
Gilles Labbe, Célestin Roussel, Nelly Buron, Bernard Fromenty, Mathieu Porceddu, Annie Borgne-Sanchez
Publikováno v:
Toxicological Sciences
Toxicological Sciences, Oxford University Press (OUP), 2012, 129 (2), pp.332-345. ⟨10.1093/toxsci/KFS197⟩
Toxicological Sciences, 2012, 129 (2), pp.332-345. ⟨10.1093/toxsci/KFS197⟩
Toxicological Sciences, Oxford University Press (OUP), 2012, 129 (2), pp.332-345. ⟨10.1093/toxsci/KFS197⟩
Toxicological Sciences, 2012, 129 (2), pp.332-345. ⟨10.1093/toxsci/KFS197⟩
International audience; Drug-induced liver injury (DILI) in humans is difficult to predict using classical in vitro cytotoxicity screening and regulatory animal studies. This explains why numerous compounds are stopped during clinical trials or withd
Autor:
Valérie Sallez, Valérie Moronvalle-Halley, Jean-Charles Gautier, Béatrice Sacre-Salem, Gilles Labbe
Publikováno v:
Toxicology. 207:203-214
The precision-cut liver slice culture model has been used widely to investigate drug metabolism and drug-induced necrosis. However, apoptosis, a key mediator of liver toxicity remains to be studied in this model. We evaluated apoptosis induced by thi
Publikováno v:
Journal of Hepatology. 66:S397