Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Gilles LAJOIE"'
Autor:
Jiesi Zhou, Yan Shu Kong, Krista M. Vincent, Dylan Dieters‐Castator, Amirali B. Bukhari, Darryl Glubrecht, Rong‐Zong Liu, Douglas Quilty, Scott D. Findlay, Xiaowei Huang, Zhihua Xu, Rui Zhe Yang, Lanyue Zhang, Emily Tang, Gilles Lajoie, David D. Eisenstat, Armin M. Gamper, Richard Fahlman, Roseline Godbout, Lynne‐Marie Postovit, YangXin Fu
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1763-1783 (2023)
Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults. The standard treatment achieves a median overall survival for GBM patients of only 15 months. Hence, novel therapies based on an increased understanding of
Externí odkaz:
https://doaj.org/article/919b27202fed43f09567395980a0f763
Autor:
Nathaniel L. Gould, Gila R. Scherer, Silvia Carvalho, Khriesto Shurrush, Haneen Kayyal, Efrat Edry, Alina Elkobi, Orit David, Maria Foqara, Darshit Thakar, Tommaso Pavesi, Vijendra Sharma, Matthew Walker, Matthew Maitland, Orly Dym, Shira Albeck, Yoav Peleg, Nicolas Germain, Ilana Babaev, Haleli Sharir, Maya Lalzar, Boris Shklyar, Neta Hazut, Mohammad Khamaisy, Maxime Lévesque, Gilles Lajoie, Massimo Avoli, Gabriel Amitai, Bruce Lefker, Chakrapani Subramanyam, Brian Shilton, Haim Barr, Kobi Rosenblum
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer’s disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, i
Externí odkaz:
https://doaj.org/article/ac5cf5dd51f14d3ba8d30c4735cde0de
Autor:
Dylan Dieters-Castator, Paola M. Dantonio, Matt Piaseczny, Guihua Zhang, Jiahui Liu, Miljan Kuljanin, Stephen Sherman, Michael Jewer, Katherine Quesnel, Eun Young Kang, Martin Köbel, Gabrielle M. Siegers, Andrew Leask, David Hess, Gilles Lajoie, Lynne-Marie Postovit
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 375-390 (2021)
The tumor microenvironment (TME) is an important mediator of breast cancer progression. Cancer-associated fibroblasts constitute a major component of the TME and may originate from tissue-associated fibroblasts or infiltrating mesenchymal stromal cel
Externí odkaz:
https://doaj.org/article/12aee79287f34bb1b635b9f1f1242d5c
Autor:
Laszlo Gyenis, Daniel Menyhart, Edward S. Cruise, Kristina Jurcic, Scott E. Roffey, Darren B. Chai, Flaviu Trifoi, Sam R. Fess, Paul J. Desormeaux, Teresa Núñez de Villavicencio Díaz, Adam J. Rabalski, Stephanie A. Zukowski, Jacob P. Turowec, Paula Pittock, Gilles Lajoie, David W. Litchfield
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes. Mapping the CSNK2-dependent phosphoproteome is necessary for better characterization of its fu
Externí odkaz:
https://doaj.org/article/a687a3d1a1db4885ab7fbc98d1c8e72c
Autor:
Yuesheng Wang, Zimin Feng, Peixin Cui, Wen Zhu, Yue Gong, Marc-André Girard, Gilles Lajoie, Julie Trottier, Qinghua Zhang, Lin Gu, Yan Wang, Wenhua Zuo, Yong Yang, John B. Goodenough, Karim Zaghib
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The specific capacity of P2-type sodium-ion battery cathode is limited because full extraction of Na ions leads to structural degradation. Here authors report pillar-beam structured material to overcome this issue by using K pillar ions to uphold the
Externí odkaz:
https://doaj.org/article/eb82215e80ac4834b06ad126f7f9f355
Autor:
Mayeul Dalleau, Stephanie Kramer‐Schadt, Yassine Gangat, Jérôme Bourjea, Gilles Lajoie, Volker Grimm
Publikováno v:
Ecology and Evolution, Vol 9, Iss 18, Pp 10317-10342 (2019)
Abstract Environmental factors shape the spatial distribution and dynamics of populations. Understanding how these factors interact with movement behavior is critical for efficient conservation, in particular for migratory species. Adult female green
Externí odkaz:
https://doaj.org/article/d9dbf355393e42acb44006a86de31cb4
Autor:
Frederik Kurzrock, Sylvain Cros, Fabrice Chane Ming, Jason A. Otkin, Axel Hutt, Laurent Linguet, Gilles Lajoie, Roland Potthast
Publikováno v:
Meteorologische Zeitschrift, Vol 27, Iss 4, Pp 277-298 (2018)
Many research and societal applications such as surface solar irradiance assessment and forecasting require accurate short-term cloudiness forecasts at kilometre and hourly scales. Today limited-area numerical weather prediction models have the poten
Externí odkaz:
https://doaj.org/article/a7bd935d2af84cf9b6872a7e5b6cfa3f
Autor:
Paul V Azzopardi, Jason O'Young, Gilles Lajoie, Mikko Karttunen, Harvey A Goldberg, Graeme K Hunter
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9330 (2010)
In vitro studies have shown that the phosphoprotein osteopontin (OPN) inhibits the nucleation and growth of hydroxyapatite (HA) and other biominerals. In vivo, OPN is believed to prevent the calcification of soft tissues. However, the nature of the i
Externí odkaz:
https://doaj.org/article/3a0b7d3c9e814018a29a8a2f38de0989
Autor:
Keith I Pardee, Xiaohui Xu, Jeff Reinking, Anja Schuetz, Aiping Dong, Suya Liu, Rongguang Zhang, Jens Tiefenbach, Gilles Lajoie, Alexander N Plotnikov, Alexey Botchkarev, Henry M Krause, Aled Edwards
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e43 (2009)
Heme is a ligand for the human nuclear receptors (NR) REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, infl
Externí odkaz:
https://doaj.org/article/d76afef7ed9440828f6f21f6b78d7b15
Autor:
Julie Cahu, Aurelien Olichon, Christian Hentrich, Henry Schek, Jovana Drinjakovic, Cunjie Zhang, Amanda Doherty-Kirby, Gilles Lajoie, Thomas Surrey
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3936 (2008)
BACKGROUND:Motor proteins from the kinesin-5 subfamily play an essential role in spindle assembly during cell division of most organisms. These motors crosslink and slide microtubules in the spindle. Kinesin-5 motors are phosphorylated at a conserved
Externí odkaz:
https://doaj.org/article/6d0a5cafa1dd49c895da0c68417ff945