Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Gilles Gosselin"'
Autor:
Jean-Pierre Sommadossi, Michel Liuzzi, Samira Benzaria-Prad, Anna Giulia Loi, Jerome Peyronnet, Claire Pierra, Dominique Louis Nestor Ghislain Surleraux, Gwenaëlle Sizun, Gilles Gosselin, Maria Seifer, Chiara Musiu, Eric Badaroux, Céline Rabeson, David Standring
Publikováno v:
Future Medicinal Chemistry. 7:1675-1700
Background: Ribonucleoside analogs possessing a β-methyl substituent at the 2′-position of the d-ribose moiety have been previously discovered to be potent and selective inhibitors of hepatitis C virus (HCV) replication, their triphosphates acting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59dc39124abc4140c4793436b2fcaab
https://doi.org/10.4155/fmc.15.96
https://doi.org/10.4155/fmc.15.96
Autor:
François-René Alexandre, Eric Badaroux, John P. Bilello, Stéphanie Bot, Tony Bouisset, Guillaume Brandt, Sylvie Cappelle, Christopher Chapron, Dominique Chaves, Thierry Convard, Clément Counor, Daniel Da Costa, David Dukhan, Marion Gay, Gilles Gosselin, Jean-François Griffon, Kusum Gupta, Brenda Hernandez-Santiago, Massimiliano La Colla, Marie-Pierre Lioure, Julien Milhau, Jean-Laurent Paparin, Jérôme Peyronnet, Christophe Parsy, Claire Pierra Rouvière, Houcine Rahali, Rachid Rahali, Aurélien Salanson, Maria Seifer, Ilaria Serra, David Standring, Dominique Surleraux, Cyril B. Dousson
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(18)
Herein we describe the discovery of IDX21437 35b, a novel RPd-aminoacid-based phosphoramidate prodrug of 2'-α-chloro-2'-β-C-methyluridine monophosphate. Its corresponding triphosphate 6 is a potent inhibitor of the HCV NS5B RNA-dependent RNA polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8795b8e1e924d640806c19eaa1d19ab
https://pubmed.ncbi.nlm.nih.gov/28835346
https://pubmed.ncbi.nlm.nih.gov/28835346
Autor:
Dominique Surleraux, Jean-Noël Volle, Claire Pierra, Coralie Laborde, Gilles Gosselin, Amadou Tidjani Ilagouma, David Virieux, Bénédicte Dayde, Jean-Luc Pirat
Publikováno v:
European Journal of Organic Chemistry. 2014:1333-1337
The first synthesis of new cyclic phosphonates (phostones), analogues of pentafuranoses containing a phosphorus atom in place of the anomeric carbon in the deoxyribose and deoxyxylose series, is described. Two methods, of respectively six and seven s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb76644c86fc5f4d35dc5ed8889cc2c9
https://doi.org/10.1002/ejoc.201301543
https://doi.org/10.1002/ejoc.201301543
Publikováno v:
Collection of Czechoslovak Chemical Communications. 76:1327-1333
An example of a 2′-C-methyl branched nucleoside analogue bearing 3,4-dihydro-3-oxopyrazine-2-carboxamide as the base, namely 4-(2-C-methyl-β-D-ribofuranosyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide, is reported. This compound was synthesized follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb952fd8ba90a2aa2b1e6d66c5d8fdb
https://doi.org/10.1135/cccc2011089
https://doi.org/10.1135/cccc2011089
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 28:435-449
In the search for inhibitors of the replication of RNA viruses, including hepatitis C virus (HCV), the hitherto unknown 4'-C-azidomethyl-beta-D-ribofuranosyl nucleosides of the five naturally occurring nucleic acid bases have been synthesized and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1e6cf6312c571df88e9b4d17a371d4
https://doi.org/10.1080/15257770903044531
https://doi.org/10.1080/15257770903044531
Autor:
Richard Storer, Jean-Pierre Sommadossi, Michel Liuzzi, Chiara Musiu, Luana Vargiu, Claire Pierra, Gilles Gosselin, Marie Hamann
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2321-2326
Several thieno[3,4-d]pyrimidine derivatives, including four hitherto unknown 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-C-nucleoside analogues of adenosine and inosine have been synthesized. When evaluated in cell culture experiments against hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacc83819f463832ea503975bcccbf99
https://doi.org/10.1016/j.bmc.2009.02.011
https://doi.org/10.1016/j.bmc.2009.02.011
Publikováno v:
Tetrahedron. 64:6657-6661
Novel regioisomers of 2′-methyl-branched nucleosides were designed and synthesized to mimic potent anti-viral drugs like Valopicitabine. The short and efficient synthesis of the targets involves a one-pot tosylation/cyclization step that leads to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f420e49758deda8dbfd1861ef752dd7f
https://doi.org/10.1016/j.tet.2008.05.022
https://doi.org/10.1016/j.tet.2008.05.022
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 26:1125-1128
The synthesis of some 3'-deoxy-3'-C-methylnucleoside analogues bearing naturally occuring nucleic acid bases was achieved from the preparation of a suitable peracylated 3-deoxy-3-C-methyl sugar using a stereoselective pathway. In addition, examples o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20ead376df2924b14bf878feec3acd3
https://doi.org/10.1080/15257770701521730
https://doi.org/10.1080/15257770701521730
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 26:1431-1434
In search for new antiviral agents, we have been interested in 1'-C-fluoromethyl branched ribonucleosides. In this paper, we describe the synthesis of 1'-C-fluoromethyladenosine via electrophilic fluorination of exo-glycal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2247c9632a80be1dd7606920b281038
https://doi.org/10.1080/15257770701542165
https://doi.org/10.1080/15257770701542165
Autor:
Dominique Surleraux, David Virieux, Arie Van der Lee, Daniel Da Costa, Gilles Gosselin, Jean-Noël Volle, Bénédicte Dayde, Amadou Tidjani Ilagouma, Claire Pierra, Jean-Luc Pirat
Publikováno v:
Tetrahedron Letters
Tetrahedron Letters, Elsevier, 2015, 56 (15), ⟨10.1016/j.tetlet.2015.03.016⟩
Tetrahedron Letters, Elsevier, 2015, 56 (15), ⟨10.1016/j.tetlet.2015.03.016⟩
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937d76562718cc868077c47770ffa4d8
https://hal.umontpellier.fr/hal-01684779
https://hal.umontpellier.fr/hal-01684779
