Výsledky vyhledávání - "Gilles Gallant"

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-1 and receptor-2 agonists for cancer therapy

Autor: Troy A. Luster, N. L. Fox, Robin Humphreys, Jerry Klein, Gilles Gallant

Publikováno v: Expert Opinion on Biological Therapy. 10:1-18

Agents that activate the TNF-related apoptosis-inducing ligand death receptors, TRAIL-R1 and TRAIL-R2, have attracted substantial attention and investment as potential anti-cancer therapies. Preclinical studies of TRAIL-R agonists indicate that they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0a80765782342cdf1227a335f6f8ed
https://doi.org/10.1517/14712590903319656

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Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer

Autor: Jeffrey Crawford, F. Anthony Greco, Karen Kelly, Yun Oh, Larry Lo, Wendy Halpern, Philip Bonomi, Jerry Klein, Gilles Gallant

Publikováno v: Lung Cancer. 61:82-90

Summary Background Preclinical pharmacological properties of mapatumumab (agonistic human monoclonal antibody to TRAIL-R1) suggest that this antibody reduces cell viability, induces cell death in many types of cancer cell lines in vitro, inhibits or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564c81e8c07fb78426c821a5c9294dd0
https://doi.org/10.1016/j.lungcan.2007.12.011

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Remission induction therapy of untreated acute myeloid leukemia using a non-cytarabine-containing regimen of idarubicin, etoposide, and carboplatin

Autor: Brent Schacter, Gaynor Williams, Donna M.M. Woloschuk, Tsiporah B. Shore, Gilles Gallant, Morel Rubinger, Eric J. Bow

Publikováno v: Cancer. 83:1344-1354

BACKGROUND The safety and efficacy of idarubicin, etoposide, and carboplatin as remission induction therapy for patients younger than 60 years with untreated acute myeloid leukemia was studied as an alternative to standard regimens based on cytarabin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6308c15ccb66f6af970700113993b583
https://doi.org/10.1002/(sici)1097-0142(19981001)83:7<1344::aid-cncr11>3.0.co

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Synthesis and in vitro anti-HIV and antitumor activity of new 2-chloroethyl thiocarbamates

Autor: Gilles Gallant, Hélène Dulude, Romano Salvador

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1523-1526

A series of new 2-chloroethyl thiocarbamates was synthesized and tested in the in vitro US-NCI primary anti-HIV and antitumor drug screens. Compound (3)d3) demonstrated some anti-HIV and antitumor activity. This compound was cytotoxic in 36 leukemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c042d4936e1b60de8249c8e83ffe6a07
https://doi.org/10.1016/0960-894x(95)00251-n

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Chemical stability of new urea and nitrosourea derivatives of diamino acids

Autor: Romano Salvador, Hélène Dulude, Gilles Gallant

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:2697-2700

Stability in neutral aqueous solutions of a series of nitrosourea derivatives of diamino acids was determined. Structure-activity relationships show that N 3 -bisubstitution increased the stability of these compounds. Moreover, in N 3 -monosubstitute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::602577cfc2e3ee669e888752f8561b51
https://doi.org/10.1016/s0960-894x(01)80699-5

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