Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Gilles Flouriot"'
Autor:
Léa Clusan, Frederic Percevault, Emmanuelle Jullion, Pascale Le Goff, Christophe Tiffoche, Tamara Fernandez‐Calero, Raphaël Métivier, Monica Marin, Farzad Pakdel, Denis Michel, Gilles Flouriot
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1302-1323 (2023)
Oestrogen receptor‐alpha (ERα) positivity is intimately associated with the development of hormone‐dependent breast cancers. A major challenge in the treatment of these cancers is to understand and overcome the mechanisms of endocrine resistance
Externí odkaz:
https://doaj.org/article/a18b6851c3da4c85afbc589534d40b27
Autor:
Morgane Davezac, Rana Zahreddine, Melissa Buscato, Natalia F. Smirnova, Chanaelle Febrissy, Henrik Laurell, Silveric Gilardi-Bresson, Marine Adlanmerini, Philippe Liere, Gilles Flouriot, Rachida Guennoun, Muriel Laffargue, Jean-Michel Foidart, Françoise Lenfant, Jean-François Arnal, Raphaël Métivier, Coralie Fontaine
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
The main estrogen, 17β-estradiol (E2), exerts several beneficial vascular actions through estrogen receptor α (ERα) in endothelial cells. However, the impact of other natural estrogens such as estriol (E3) and estetrol (E4) on arteries remains poo
Externí odkaz:
https://doaj.org/article/cee391bdb2374d7ba32e1f7c699de3f8
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6834 (2023)
Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hor
Externí odkaz:
https://doaj.org/article/23c62320a73047339e81ccc30dbb46d5
Autor:
Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Background During breast cancer progression, the epithelial to mesenchymal transition has been associated with metastasis and endocrine therapy resistance; however, the underlying mechanisms remain elusive. To gain insight into this process,
Externí odkaz:
https://doaj.org/article/87dbd3fcc1344db092b9283e458aacae
Autor:
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, Jordan Rivron, Manuela CL Garcia, Léa Réthoré, Rana Zahreddine, Morgane Davezac, Chanaelle Fébrissy, Marine Adlanmerini, Laurent Loufrani, Vincent Procaccio, Jean-Michel Foidart, Gilles Flouriot, Françoise Lenfant, Coralie Fontaine, Jean-François Arnal, Daniel Henrion
Publikováno v:
eLife, Vol 10 (2021)
Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action, whereas plasma membrane-located ERα accelerates endothelial healing. The genetic deficiency of ERα was associated with a reduction in flow-mediated
Externí odkaz:
https://doaj.org/article/9a36969e61414a318a017f8e1eddcd91
Autor:
Thu Ha Pham, Yann Le Page, Frédéric Percevault, François Ferrière, Gilles Flouriot, Farzad Pakdel
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 470 (2021)
Approximately 80% of breast cancer (BC) cases express the estrogen receptor (ER), and 30–40% of these cases acquire resistance to endocrine therapies over time. Hyperactivation of Akt is one of the mechanisms by which endocrine resistance is acquir
Externí odkaz:
https://doaj.org/article/cf183ad118b543ffb6046cc3c5e92c3c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 756 (2021)
Breast cancer (BC) is the most common cancer among women worldwide. More than 70% of BC cases express estrogen receptor alpha (ERα), a central transcription factor that stimulates the proliferation of breast cancer cells, usually in the presence of
Externí odkaz:
https://doaj.org/article/80fb24caa9ca4eceb52d17fbb0e8300f
Autor:
Anne Abot, Coralie Fontaine, Mélissa Buscato, Romain Solinhac, Gilles Flouriot, Aurélie Fabre, Anne Drougard, Shyamala Rajan, Muriel Laine, Alain Milon, Isabelle Muller, Daniel Henrion, Marine Adlanmerini, Marie‐Cécile Valéra, Anne Gompel, Céline Gerard, Christel Péqueux, Mélanie Mestdagt, Isabelle Raymond‐Letron, Claude Knauf, François Ferriere, Philippe Valet, Pierre Gourdy, Benita S Katzenellenbogen, John A Katzenellenbogen, Françoise Lenfant, Geoffrey L Greene, Jean‐Michel Foidart, Jean‐François Arnal
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1328-1346 (2014)
Abstract Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E2) and E4 are
Externí odkaz:
https://doaj.org/article/f81d485b302d454596333e69beb5f6bc
Autor:
Mylène Potier, Catherine Bennetau-Pelissero, Gilles Flouriot, Charlotte Carreau, Svitlana Shinkaruk
Publikováno v:
Nutrients, Vol 2, Iss 3, Pp 340-354 (2010)
Equol, one of the main metabolites of daidzein, is a chiral compound with pleiotropic effects on cellular signaling. This property may induce activation/inhibition of the estrogen receptors (ER) a or b, and therefore, explain the beneficial/deleterio
Externí odkaz:
https://doaj.org/article/92090dc952c0470cbf78a7767e5d11ba
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e69081 (2013)
Many studies have reported proliferative, differentiating or protective effects of estradiol, notably through estrogen receptor alpha (ERα). On the contrary, the ligand-independent action of ERα is currently poorly documented notably in cell protec
Externí odkaz:
https://doaj.org/article/f57c023534e2427cb12ac59f5d6fa936