Výsledky vyhledávání - "Gilles Flatau"

Akademický článek

Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA).

Autor: Christoph Beitzinger, Caroline Stefani, Angelika Kronhardt, Monica Rolando, Gilles Flatau, Emmanuel Lemichez, Roland Benz

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46964 (2012)

It is of interest to define bacterial toxin biochemical properties to use them as molecular-syringe devices in order to deliver enzymatic activities into host cells. Binary toxins of the AB(7/8)-type are among the most potent and specialized bacteria

Externí odkaz: https://doaj.org/article/cc8517eb4d8b43369fc1b9bd17c3bc37

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Akademický článek

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells.

Autor: Angelika Kronhardt, Monica Rolando, Christoph Beitzinger, Caroline Stefani, Michael Leuber, Gilles Flatau, Michel R Popoff, Roland Benz, Emmanuel Lemichez

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23133 (2011)

Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and exhibit fatal enzymatic activities in eukaryotic cells. Anthrax and C2 toxin are the most prominent examples for the AB(7/8) type of t

Externí odkaz: https://doaj.org/article/bfbaa0c9d25a471dbf8b0edf677a342b

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Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity

Autor: Musa M. Mhlanga, Amel Mettouchi, Gilles Flatau, Caroline Stefani, Ulf R. Rapp, Patrick Auberger, Emmanuel Lemichez, Monica Rolando, Antoine Galmiche

Publikováno v: Cellular Microbiology. 12:891-905

We have investigated how Bacillus anthracis lethal toxin (LT) triggers caspase-3 activation and the formation of thick actin cables in human endothelial cells. By DNA array analysis we show that LT has a major impact on the cell transcriptome and we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::348b0c2128d54f83c5c3998666f10ef8
https://doi.org/10.1111/j.1462-5822.2010.01438.x

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Injection of Staphylococcus aureus EDIN by the Bacillus anthracis Protective Antigen Machinery Induces Vascular Permeability

Autor: Caroline Stefani, Patrick Auberger, Emmanuel Lemichez, Gilles Flatau, Monica Rolando, Patrick Munro

Publikováno v: Infection and Immunity. 77:3596-3601

Systemic injection of Bacillus anthracis lethal toxin (LT) produces vascular leakage and animal death. Recent studies suggest that LT triggers direct endothelial cell cytotoxicity that is responsible for the vascular leakage. LT is composed of heptam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c11de1781214a426a3c4500993150d
https://doi.org/10.1128/iai.00186-09

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Structural basis for the NAD-hydrolysis mechanism and the ARTT-loop plasticity of C3 exoenzymes

Autor: Patrice Boquet, Gilles Flatau, André Ménez, Enrico A. Stura, Julie Ménétrey

Publikováno v: Protein Science. 17:878-886

C3-like exoenzymes are ADP-ribosyltransferases that specifically modify some Rho GTPase proteins, leading to their sequestration in the cytoplasm, and thus inhibiting their regulatory activity on the actin cytoskeleton. This modification process goes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751993b63d7f7044c9cd2e6c327805b4
https://doi.org/10.1110/ps.073398508

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Isoform-specific Interaction of C-RAF with Mitochondria

Autor: Ilka Wittig, Ansgar Santel, Monica Rolando, Emmanuel Lemichez, Gilles Flatau, Ulf R. Rapp, Georg Krohne, Jochen Fueller, Antoine Galmiche, Anne Doye

Publikováno v: Journal of Biological Chemistry. 283:14857-14866

The proteins of the RAF family (A-RAF, B-RAF, and C-RAF) are serine/threonine kinases that play important roles in development, mature cell regulation, and cancer. Although it is widely held that their localization on membranes is an important aspect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54931630287463cfbfecf51506080886
https://doi.org/10.1074/jbc.m709098200

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Rho/Rho-associated Kinase-II Signaling Mediates Disassembly of Epithelial Apical Junctions

Autor: Asma Nusrat, Gilles Flatau, Andrei I. Ivanov, Charles A. Parkos, Stanislav N. Samarin

Publikováno v: Molecular Biology of the Cell. 18:3429-3439

Apical junctional complex (AJC) plays a vital role in regulation of epithelial barrier function. Disassembly of the AJC is observed in diverse physiological and pathological states; however, mechanisms governing this process are not well understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d2e479611d33dec252d05ff47fe08e
https://doi.org/10.1091/mbc.e07-04-0315

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Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors

Autor: Pierre Gounon, Céline Pulcini, Patrick Munro, Luce Landraud, René L. Clément, Olivier Dussurget, Emmanuel Lemichez, Amel Mettouchi, Gilles Flatau, Anne Doye, Monica Rolando, Michel R. Popoff, Laurent Boyer

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, 2006, 173, pp.809-19. ⟨10.1083/jcb.200509009⟩
Journal of Cell Biology, Rockefeller University Press, 2006, 173, pp.809-19. ⟨10.1083/jcb.200509009⟩
The Journal of Cell Biology

The GTPase RhoA is a major regulator of the assembly of actin stress fibers and the contractility of the actomyosin cytoskeleton. The epidermal cell differentiation inhibitor (EDIN) and EDIN-like ADP-ribosyltransferases of Staphylococcus aureus catal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d36ceaf335c0bb956a5469d048fa50f
https://doi.org/10.1083/jcb.200509009

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