Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery

Autor: Vincent Boudy, Ni Zeng, Michel Bessodes, Gilles Dumortier, Nathalie Mignet, Daniel Scherman, Marc Maury, Hélène Dhotel, Johanne Seguin, Pierre-Louis Destruel

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2017, 534 (1-2), pp.128-135. ⟨10.1016/j.ijpharm.2017.09.073⟩
International Journal of Pharmaceutics, 2017, 534 (1-2), pp.128-135. ⟨10.1016/j.ijpharm.2017.09.073⟩

Buccal administration route is a promising way for a large number of drugs exhibiting a low oral bioavailability. The present work describes the formulation and evaluation of a mucoadhesive and thermosensitive in situ gelling delivery system based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7304400ceb91d0533158acaf3a4c961
https://hal.archives-ouvertes.fr/hal-02123148

Altered HepG2 cell models using etomoxir versus tert-butylhydroperoxide

Autor: Véronique Vincourt, Jean-Claude Chaumeil, Virginie Escriou, Michel Bessodes, Céline Largeau, Gilles Dumortier, Daniel Scherman

Publikováno v: Cell Biology and Toxicology. 27:363-370

Energetic failure which occurs in both ischemia/reperfusion and acute drug-induced hepatotoxicity is frequently associated with oxidative stress. This study displays the setting of a new cell culture model for hepatic energetic failure, i.e., HepG2 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311329496577d6ca6abad0ea604e4194
https://doi.org/10.1007/s10565-011-9193-7

Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line

Autor: Gilles Dumortier, Daniel Scherman, Marc Maury, Elodie Olivier, Ni Zeng, Patrice Rat, Vincent Boudy, Nathalie Mignet, Johanne Seguin

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2015, 495 (2), pp.1028-1037. ⟨10.1016/j.ijpharm.2015.09.045⟩

International audience; A salbutamol sulfate (SS)-Poloxamer bioadhesive hydrogel specially developed for buccal administration was investigated by studying interactions with TR146 human buccal epithelium cells (i.e. cellular toxicity (i) and trans-ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a13c7f258df59c887d27ef80732baac
https://hal-cnrs.archives-ouvertes.fr/hal-03290547

Generic Control/Command Distributed System – Application to the Supervision of Moving Stage Sets in Theaters

Autor: Anne-Lise Gehin, Nicolas Flix, Abdel Aitouche, Gilles Dumortier

Publikováno v: European Journal of Control. 8:64-75

Supervision system requires not only a high-speed system, but also high reliability (i.e. fault-tolerant systems), high flexibility (generic design) and high scalability (distributed design). Industrial applications have revealed these absolute needs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c0986b96da04e511b309bf5f9a1b834
https://doi.org/10.3166/ejc.8.64-75

Freeze-drying of ATP entrapped in cationic, low lipid liposomes

Autor: Véronique Vincourt, Luan Nguyen, Gilles Dumortier, Jean-Claude Chaumeil

Publikováno v: Cryobiology. 60(3)

Concerning the instability of ATP liposomes formulated to easily diffuse through the liver (size approximately 100 nm), this work targets the key parameters that influence the freeze-drying of a preparation that combines cholesterol, DOTAP and phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f80c917741721dab6846f8682466bc
https://pubmed.ncbi.nlm.nih.gov/20097191