Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Gilles Divita"'
Autor:
Gilles Divita, Audrey Grunenberger, Elodie Czuba, Khadidja Boularache, Melanie Guidetti, Veronique Josserand, Neil Desai
Publikováno v:
Cancer Research. 83:550-550
The p53 tumor suppressor mutations resulting in loss of function control tumor proliferation in 50% of human cancers. TP53 missense and nonsense mutations are present in about 50% and 7-12% of the p53 driven cancer, respectively. To date there is no
Autor:
Anna Rydström, Sébastien Deshayes, Karidia Konate, Laurence Crombez, Kärt Padari, Hassan Boukhaddaoui, Gudrun Aldrian, Margus Pooga, Gilles Divita
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25924 (2011)
Cell penetrating peptides constitute a potent approach to overcome the limitations of in vivo siRNA delivery. We recently proposed a peptide-based nanoparticle system, CADY, for efficient delivery of siRNA into numerous cell lines. CADY is a secondar
Externí odkaz:
https://doaj.org/article/156d0857b4dd421aa6d4ce2dc97b696c
Autor:
Véronique Josserand, Neil Desai, Elodie Czuba, Audrey Gunenberger, Mélanie Guidetti, Gilles Divita, Leslie Tempremant
Publikováno v:
Cancer Research. 80:1826-1826
Background: KRASG12V and KRASG12D mutations are among the most commonly observed mutations in pancreatic (30% and 51%) and colorectal (27% and 45%) adenocarcinomas and have been associated with poor prognosis. Activating mutations in KRAS play potent
Autor:
Roger S. Goody, Gilles Divita, Véronique Robert-Hebmann, Christian Devaux, Jean Mery, May C. Morris, Laurent Chaloin, Frédéric Heitz
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (16), pp.6658. ⟨10.1074/jbc.AAC119.008640⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (16), pp.6658. ⟨10.1074/jbc.AAC119.008640⟩
The biologically relevant and active forms of human immunodeficiency viruses type 1 and 2 reverse transcriptase found in infectious virions are heterodimers produced in a two-step dimerization process. Dimerization involves first the rapid associatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65b2506ebe74e4947d77c389f7d621f
https://europepmc.org/articles/PMC6484107/
https://europepmc.org/articles/PMC6484107/
Publikováno v:
Cancer Research. 78:3948-3948
Background : The tumor suppressor PTEN and the KRAS oncogene play essential roles in tumorigenesis. PTEN mutations and resulting loss of function are common across variety of tumors and influence tumor cell proliferation. KRAS mutations occur in > 40
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2010, epub ahead of print. ⟨10.1016/j.bbamem.2010.03.005⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2010, epub ahead of print. ⟨10.1016/j.bbamem.2010.03.005⟩
International audience; The clinical use of efficient therapeutic agents is often limited by the poor permeability of the biological membranes. In order to enhance their cell delivery, short amphipathic peptides called cell-penetrating peptides (CPPs
Autor:
Jan Ferner, Julia Dietz, Manuel Grez, Yves Mély, Gilles Divita, Norbert Bannert, Harald Schwalbe, Stefan Stein, Lars Möller, Chinnappan Raja, Joachim Koch, Robert Tampé, Anette Pustowka, Ajit Kaur, Sarah Mensch, Ursula Dietrich
Publikováno v:
ChemMedChem. 3:749-755
The interaction of the nucleocapsid NCp7 of the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein with the RNA packaging signal Psi ensures specific encapsidation of the dimeric full length viral genome into nascent virus particles. Being a
Autor:
May C. Morris, Edwige Gros, Julien Depollier, Sébastien Deshayes, Gilles Divita, Frédéric Heitz, Gudrun Aldrian-Herrada
Publikováno v:
Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2006, 1758 (3), pp.384-393. ⟨10.1016/j.bbamem.2006.02.006⟩
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2006, 1758 (3), pp.384-393. ⟨10.1016/j.bbamem.2006.02.006⟩
International audience; The development of therapeutic peptides and proteins is limited by the poor permeability and the selectivity of the cell membrane. The discovery of protein transduction domains has given a new hope for administration of large
Autor:
Andy Arvai, Claire Gondeau, Karl-Peter Hopfner, Paul Bello, Gilles Divita, Federica Simeoni, Paolo Neyroz, John A. Tainer, F. Heitz
Publikováno v:
Biochemistry. 44:11997-12008
The U4/U6*U5 tri-snRNP complex is the catalytic core of the pre-mRNA splicing machinery. The thioredoxin-like protein hDim1 (U5-15 kDa) constitutes an essential component of the U5 particle, and its functions have been reported to be highly conserved
Autor:
May C. Morris, Claire Gondeau, Gilles Divita, Paul Bello, Sabine Gerbal-Chaloin, Gudrun Aldrian-Herrada
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (14), pp.13793-13800. ⟨10.1074/jbc.M413690200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (14), pp.13793-13800. ⟨10.1074/jbc.M413690200⟩
International audience; Cyclin dependent kinases (CDKs) are key regulators of the cell cycle progression and therefore constitute excellent targets for the design of anticancer agents. Most of the inhibitors identified to date inhibit kinase activity