Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gilles Degotte"'
Autor:
Jean-Gonfi Mvondo Mbala, Dani Thierry Mawete, Alain Nanikafuako Makiese, Prosper Lwanzo Kwiraviwe, Bibiche Kuyubuka Pangu, Eric Buini Nguimi, Richard Cimanga Kanyanga, Luc Pieters, Gilles Degotte, Michel Frederich, Aristote Matondo, Natascha Van Pelt, Guy Caljon, Bernard Pirotte, Blaise Mbala Mavinga, Sylvie-Mireille Bambi-Nyanguile
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101284- (2024)
After establishment of the pharmacokinetic and toxicological profile of quinine derivatives using in silico approaches, this study reports the synthesis of new acetyl and benzoyl esters of quinine bearing one or more fluorine or chlorine atoms on the
Externí odkaz:
https://doaj.org/article/a559aa89d2134a43a59855d9369fe10d
Autor:
Olivier Bonnet, Mehdi A. Beniddir, Pierre Champy, Gilles Degotte, Lúcia Mamede, Pauline Desdemoustier, Allison Ledoux, Alembert Tiabou Tchinda, Luc Angenot, Michel Frédérich
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Malaria, a disease known for thousands of years and caused by parasites of the Plasmodium genus, continues to cause many deaths throughout the world today, particularly due to the emergence of parasite resistance to the current therapeutic arsenal. P
Externí odkaz:
https://doaj.org/article/cc95df9aa42b45a8a0fd945b67d92064
Autor:
Gilles Degotte, Michel Frederich, Pierre Francotte, Thierry Franck, Thomas Colson, Didier Serteyn, Ange Mouithys-Mickalad
Publikováno v:
Molecules, Vol 28, Iss 11, p 4516 (2023)
Malaria is an infectious disease caused by a Plasmodium genus parasite that remains the most widespread parasitosis. The spread of Plasmodium clones that are increasingly resistant to antimalarial molecules is a serious public health problem for unde
Externí odkaz:
https://doaj.org/article/ad8d0402df5148afae8bf6bf61a88fd0
Autor:
Andrzej Bak, Jiri Kos, Gilles Degotte, Aleksandra Swietlicka, Tomas Strharsky, Dominika Pindjakova, Tomas Gonec, Adam Smolinski, Pierre Francotte, Michel Frederich, Violetta Kozik, Josef Jampilek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3611 (2023)
A series of seventeen 4-chlorocinnamanilides and seventeen 3,4-dichlorocinnamanilides were characterized for their antiplasmodial activity. In vitro screening on a chloroquine-sensitive strain of Plasmodium falciparum 3D7/MRA-102 highlighted that 23
Externí odkaz:
https://doaj.org/article/0dc5f882afc74f9d96aec6749923e6f1
Autor:
Jiri Kos, Gilles Degotte, Dominika Pindjakova, Tomas Strharsky, Timotej Jankech, Tomas Gonec, Pierre Francotte, Michel Frederich, Josef Jampilek
Publikováno v:
Molecules, Vol 27, Iss 22, p 7799 (2022)
Due to the urgent need of innovation in the antimalarial therapeutic arsenal, a series of thirty-seven ring-substituted N-arylcinnamanilides prepared by microwave-assisted synthesis were subjected to primary screening against the chloroquine-sensitiv
Externí odkaz:
https://doaj.org/article/168f27855ded41ada34cba2b3a7867c2
Autor:
Gilles Degotte, Hélène Pendeville, Carla Di Chio, Roberta Ettari, Bernard Pirotte, Michel Frédérich, Pierre Francotte
Publikováno v:
RSC Medicinal Chemistry. 14:715-733
A polyphenolic scaffold to develop novel orally active antimalarials against resistant Plasmodium falciparum.
Publikováno v:
Letters in Drug Design & Discovery. 19:823-836
Background: Malaria was one of the deadliest infectious diseases in 2021. Indeed, this infection, mostly caused by a protozoan called Plasmodium falciparum, is responsible for more than 200 million cases and around 400 000 related deaths annually, ma
Autor:
Mouithys-Mickalad, Gilles Degotte, Michel Frederich, Pierre Francotte, Thierry Franck, Thomas Colson, Didier Serteyn, Ange
Publikováno v:
Molecules; Volume 28; Issue 11; Pages: 4516
Malaria is an infectious disease caused by a Plasmodium genus parasite that remains the most widespread parasitosis. The spread of Plasmodium clones that are increasingly resistant to antimalarial molecules is a serious public health problem for unde
Publikováno v:
Archiv der PharmazieREFERENCES. 354(11)
With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malar
Publikováno v:
Current medicinal chemistry. 28(30)
Background: Despite major advances in the fight against this parasitic disease, malaria remained a major cause of concern in 2021. This infection, mainly due to Plasmodium falciparum, causes more than 200 million cases every year and hundreds of thou