Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gilles B. Tremblay"'
Autor:
Jasminka Korcok, Gilles B. Tremblay, Souzan Armstrong, Svetlana V. Komarova, Stephen M. Sims, Alexey Pereverzev, S. Jeffrey Dixon
Publikováno v:
Physiology and Pharmacology Publications
Systemic acidosis has detrimental effects on the skeleton and local acidosis is associated with bone destruction in inflammatory and neoplastic diseases. However, the mechanisms by which acidosis enhances osteoclastic bone resorption are poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b76cf42fba834211bae259ee882391
https://doi.org/10.1016/j.bone.2007.08.044
https://doi.org/10.1016/j.bone.2007.08.044
Autor:
Miklos Feher, Robert Dunn-Dufault, Jonathan M. Schmidt, Julie Mercure, Gilles B. Tremblay, Markus G. Peter, Peter R. Redden, Martine Pagé
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:1389-1396
There is still a strong need for additional diversity and new chemical scaffolds to allow for the exploration of improved tissue selectivity and finding better selective estrogen receptor modulators (SERMs). Using a de novo design technology a diphen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572a017398ad92388afab7acb86efc33
https://doi.org/10.1016/s0968-0896(02)00647-8
https://doi.org/10.1016/s0968-0896(02)00647-8
Autor:
Martine Pagé, Aida Kalbakji, Markus G. Peter, Jonathan M. Schmidt, Gilles B. Tremblay, Julie Mercure, Peter R. Redden, Miklos Feher, Robert Dunn-Dufault
Publikováno v:
Journal of Medicinal Chemistry. 46:1408-1418
Although there are many estrogen receptor antagonists with improved tissue selectivity profiles compared with tamoxifen, optimal tissue selectivity has not yet been demonstrated. As such there is still a need for additional diversity and new chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7379b505242e2ac4dd96ec3242c119b
https://doi.org/10.1021/jm020536q
https://doi.org/10.1021/jm020536q
Publikováno v:
Molecular Cell. 3:513-519
The estrogen receptors (ERs) alpha and beta possess a constitutive N-terminal activation function (AF-1) whose activity can be modulated by kinase signalling pathways. We demonstrate here that phosphorylation of AF-1 by MAP kinase (MAPK) leads to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a12a3dff48e19dc4c15ee9a5227fd9d
https://doi.org/10.1016/s1097-2765(00)80479-7
https://doi.org/10.1016/s1097-2765(00)80479-7
Autor:
Fupeng Ma, Miklos Feher, Michael A Plastina, Robert Dunn-Dufault, Peter R. Redden, Jonathan M. Schmidt, Sanjivanjit Bhal neé Basra, Gilles B. Tremblay
Publikováno v:
Bioorganicmedicinal chemistry. 13(5)
There is still a need for additional scaffolds to further explore tissue selectivity and improving efficacy of selective estrogen receptor modulators (SERMs). A series of hydroxyl substituted diphenylnaphthyl alkene ligands for the two estrogen recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413ce0cf27d9bfc48025f492943de3de
https://pubmed.ncbi.nlm.nih.gov/15776560
https://pubmed.ncbi.nlm.nih.gov/15776560
Autor:
Peter R. Redden, Markus G. Peter, Martine Pagé, Miklos Feher, Robert Dunn-Dufault, Gilles B. Tremblay, Jonathan M. Schmidt, Julie Mercure
Publikováno v:
Journal of medicinal chemistry. 46(8)
The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91be8c37f7ad02ed302084b2dcf40d89
https://pubmed.ncbi.nlm.nih.gov/12672229
https://pubmed.ncbi.nlm.nih.gov/12672229
Autor:
Gilles B. Tremblay, Vincent Giguere
Publikováno v:
Critical Reviews in Eukaryotic Gene Expression. 12:22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa23f13ef95deac9d472e2130f7b5873
https://doi.org/10.1615/critreveukargeneexpr.v12.i1.10
https://doi.org/10.1615/critreveukargeneexpr.v12.i1.10