Zobrazeno 1 - 10
of 509
pro vyhledávání: '"Gilles, Vassal"'
Autor:
Marko Otsokolhich, Maxime Annereau, Tiene Bauters, Laszlo Horvath, Chahinez Nehal, Sherif Kamal, Gilles Vassal, Svetlana Buraja
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100163- (2024)
Introduction: Scarcity of age appropriate formulations for orally administered medicines for paediatric malignancies is a critical and ongoing issue which necessitates urgent solutions. According to JARC Survey 27 % of oral medicines were never avail
Externí odkaz:
https://doaj.org/article/9d290e1fafa7402db910dc9b6d911141
Autor:
Jelena Roganovic, Ewa Bien, Andrea Ferrari, Gilles Vassal, Annalisa Trama, Paolo G. Casali, Annita Kienesberger, Gianni Bisogno, Calogero Virgone, Tal Ben Ami, Yves Reguerre, Jan Godzinski, Nuno Jorge Farinha, Luca Bergamaschi, Dominik T. Schneider, Daniel Orbach, Ines B. Brecht
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100130- (2023)
Very rare cancers in children and adolescents pose a unique challenge for optimal care and research. Due to their rarity and diversity, there is a lack of standardized treatments and limited data to guide clinical decision-making. This paper aims to
Externí odkaz:
https://doaj.org/article/4258fb889aab474eb2b3e91f04e639d6
Autor:
Teresa deRojas, Pamela Kearns, Patricia Blanc, Jeffrey Skolnik, Elizabeth Fox, Leona Knox, Raphael Rousseau, François Doz, Nick Bird, Andrew J. Pearson, Gilles Vassal
Publikováno v:
Cancer Medicine, Vol 12, Iss 7, Pp 8825-8837 (2023)
Abstract Background More effective incentives are needed to motivate paediatric oncology drug development, uncoupling it from dependency on adult drug development. Although the current European and North‐American legislations aim to promote drug de
Externí odkaz:
https://doaj.org/article/773c8ee157744c12badbc7afefcd921b
Autor:
Katharine Cheng, Fenna Mahler, Irja Lutsar, Begonya Nafria Escalera, Stefanie Breitenstein, Gilles Vassal, Joana Claverol, Nuria Noel Palacio, Ron Portman, Gavin Pope, Martijn Bakker, Tessa van derGeest, Mark A. Turner, Saskia N. deWildt, c4c Expert Group Leads
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 478-488 (2023)
Abstract Many medicines are used “off‐label” in children outside the terms of the license. Feasible pediatric clinical trials are a challenge to design. Conect4children (c4c) is an Innovative Medicines Initiative project to set up a pan‐Europ
Externí odkaz:
https://doaj.org/article/c0e2c9a0347a4e119c1b97f392a17d3d
Autor:
Maria Eugenia Marques da Costa, Robin Droit, Pierre Khneisser, Anne Gomez-Brouchet, Tiphaine Adam-de-Beaumais, Marie Nolla, Nicolas Signolles, Jacob Torrejon, Bérangère Lombard, Damarys Loew, Olivier Ayrault, Jean-Yves Scoazec, Birgit Geoerger, Gilles Vassal, Antonin Marchais, Nathalie Gaspar
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Osteosarcoma is a rare bone cancer in adolescents and young adults with a dismal prognosis because of metastatic disease and chemoresistance. Despite multiple clinical trials, no improvement in outcome has occurred in decades. There is an urgent need
Externí odkaz:
https://doaj.org/article/2a610dad48cc46c4805a492616f11430
Autor:
James C. H. Yang, Marcia S. Brose, Gilberto Castro, Edward S. Kim, Ulrik N. Lassen, Serge Leyvraz, Alberto Pappo, Fernando López-Ríos, John A. Reeves, Marc Fellous, Frédérique Penault-Llorca, Erin R. Rudzinski, Ghazaleh Tabatabai, Gilles Vassal, Alexander Drilon, Jonathan Trent
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Tropomyosin receptor kinase (TRK) fusion proteins resulting from neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare primary oncogenic drivers in a wide array of tumors. Larotrectinib is a first-in-class, highly sel
Externí odkaz:
https://doaj.org/article/d03b60bd6de0450a90283154c262afe5
Autor:
Teresa deRojas, Andrew J. Pearson, Nicole Scobie, Leona Knox, Darshan Wariabharaj, Pamela Kearns, Gilles Vassal, Gregory Reaman
Publikováno v:
Cancer Medicine, Vol 10, Iss 23, Pp 8462-8474 (2021)
Abstract Background Since pediatric cancer drug development is a global enterprise, we sought to provide an overview of the landscape of intercontinental clinical trials in pediatric oncology opened over the last decade. Methods ClinicalTrials.gov wa
Externí odkaz:
https://doaj.org/article/2427915acca44221ada508c18a3dc005
Autor:
Simon Bailey, Alan Davidson, Jeannette Parkes, Uri Tabori, Anthony Figaji, Shridar Epari, Girish Chinnaswamy, Rosdali Diaz-Coronado, Sandro Casavilca-Zambrano, Nisreen Amayiri, Gilles Vassal, Eric Bouffet, Steven C. Clifford
Publikováno v:
JCO Global Oncology, Vol , Iss 8 (2022)
Externí odkaz:
https://doaj.org/article/c29213b703e445a78d71ee829c2e2cc1
Autor:
Arthur Felix, Pablo Berlanga, Maud Toulmonde, Judith Landman‐Parker, Sarah Dumont, Gilles Vassal, Marie‐Cécile Le Deley, Nathalie Gaspar
Publikováno v:
Cancer Medicine, Vol 10, Iss 5, Pp 1589-1604 (2021)
Abstract Background Optimal Phase‐II design to evaluate new therapies in refractory/relapsed Ewing sarcomas (ES) remains imperfectly defined. Objectives Recurrent/refractory ES phase‐I/II trials analysis to improve trials design. Methods Comprehe
Externí odkaz:
https://doaj.org/article/b6c7f503d5e0493b98b803fc267a35b3
Autor:
Sonia Cournoyer, Anissa Addioui, Assila Belounis, Mona Beaunoyer, Carine Nyalendo, Roxane Le Gall, Pierre Teira, Elie Haddad, Gilles Vassal, Hervé Sartelet
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is also implicated in tu
Externí odkaz:
https://doaj.org/article/384d2fe4c3b04a5e9f90f3e292ea8d67