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Halogen-atom and group transfer reactivity enabled by hydrogen tunneling.

Autor: Constantin T; Department of Chemistry, University of Manchester, Manchester M13 9PL, UK., Górski B; Department of Chemistry, University of Manchester, Manchester M13 9PL, UK., Tilby MJ; Department of Chemistry, University of Manchester, Manchester M13 9PL, UK., Chelli S; CNRS/Université Toulouse III-Paul Sabatier, Laboratoire Hétérochimie Fondamentale et Appliquée, LHFA UMR 5069, 31062 Toulouse Cedex 09, France., Juliá F; Department of Chemistry, University of Manchester, Manchester M13 9PL, UK., Llaveria J; Global Discovery Chemistry, Therapeutics Discovery, Janssen Research & Development, Janssen-Cilag S.A., 45007 Toledo, Spain., Gillen KJ; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK., Zipse H; Department Chemie, LMU München, D-81377 München, Germany., Lakhdar S; CNRS/Université Toulouse III-Paul Sabatier, Laboratoire Hétérochimie Fondamentale et Appliquée, LHFA UMR 5069, 31062 Toulouse Cedex 09, France., Leonori D; Institute of Organic Chemistry, RWTH Aachen University, 52056 Aachen, Germany.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Sep 16; Vol. 377 (6612), pp. 1323-1328. Date of Electronic Publication: 2022 Sep 15.

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.

Autor: Chapman TM; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Gillen KJ; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Wallace C; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Lee MT; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Bakrania P; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Khurana P; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Coombs PJ; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Stennett L; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Fox S; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Bureau EA; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Brownlees J; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK., Melton DW; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK., Saxty B; Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, UK.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Oct 01; Vol. 25 (19), pp. 4097-103. Date of Electronic Publication: 2015 Aug 17.

A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.

Autor: Jamieson C; Merck Research Laboratories, MSD, Newhouse, Motherwell, Lanarkshire, UK. craig.jamieson@strath.ac.uk, Campbell RA, Cumming IA, Gillen KJ, Gillespie J, Kazemier B, Kiczun M, Lamont Y, Lyons AJ, Maclean JK, Martin F, Moir EM, Morrow JA, Pantling J, Rankovic Z, Smith L

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Oct 15; Vol. 20 (20), pp. 6072-5. Date of Electronic Publication: 2010 Aug 15.