Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

Autor: Duffy, David L, Zhu, Gu, Xin, Li, Sanna, Marianna, Iles, Mark M, Jacobs, Leonie C, Evans, David M, Yazar, Seyhan, Beesley, Jonathan, Law, Matthew H, Kraft, Peter, Visconti, Alessia, Taylor, John C, Lui, Fan, Wright, Margaret J, Henders, Anjali K, Bowdler, Lisa, Glass, Dan, Ikram, Arfan M, Uitterlinden, André G, Madden, Pamela A, Heath, Andrew C, Nelson, Elliot C, Green, Adele C, Chanock, Stephen, Barrett, Jennifer H, Brown, Matthew A, Hayward, Nicholas K, Macgregor, Stuart, Sturm, Richard A, Hewitt, Alex W, Kayser, Manfred, Hunter, David J, Newton Bishop, Julia A, Spector, Timothy D, Montgomery, Grant W, Mackey, David A, Smith, George Davey, Nijsten, Tamar E, Bishop, D Timothy, Bataille, Veronique, Falchi, Mario, Han, Jiali, Martin, Nicholas, G, Lee, Je, Brossard, M, Moses, Ek, Song, F, Kumar, R, Easton, Df, Pharoah, Pdp, Swerdlow, Aj, Kypreou, Kp, Harland, M, Randerson-Moor, J, Akslen, La, Andresen, Pa, Avril, Mf, Azizi, E, Scarrà, Gb, Brown, Km, Dębniak, T, Elder, De, Fang, S, Friedman, E, Galan, P, Ghiorzo, P, Gillanders, Em, Goldstein, Am, Gruis, Na, Hansson, J, Helsing, P, Hočevar, M, Höiom, V, Ingvar, C, Kanetsky, Pa, Chen, Wv, Landi, Mt, Lang, J, Lathrop, Gm, Lubiński, J, Mackie, Rm, Mann, Gj, Molven, A, Novaković, S, Olsson, H, Puig, S, Puig-Butille, Ja, Radford-Smith, Gl, van der Stoep, N, van Doorn, R, Whiteman, Dc, Craig, Je, Schadendorf, D, Simms, La, Burdon, Kp, Nyholt, Dr, Pooley, Ka, Orr, N, Stratigos, Aj, Cust, Ae, Ward, Sv, Schulze, Hj, Dunning, Am, Demenais, F, Amos, Ci.

Publikováno v: Nature Communications, 9:4774. Nature Publishing Group
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Duffy, D L, Zhu, G, Li, X, Sanna, M, Iles, M M, Jacobs, L C, Evans, D M, Yazar, S, Beesley, J, Law, M H, Kraft, P, Visconti, A, Taylor, J C, Lui, F, Henders, A K, Bowdler, L, Glass, D, Ikram, A M, Uitterlinden, A G, Wright, M J, Madden, P A, Heath, A C, Nelson, E C, Green, A C, Chanock, S, Barrett, J H, Brown, M A, Hayward, N K, MacGregor, S, Sturm, R A, Hewitt, A W, Kayser, M, Hunter, D J, Newton Bishop, J A, Spector, T D, Montgomery, G W, Mackey, D A, Smith, G D, Nijsten, T E, Bishop, D T, Bataille, V, Falchi, M & Han, J & Martin, N G 2018, ' Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways ', Nature Communications, vol. 9, no. 1, pp. 4774 . https://doi.org/10.1038/s41467-018-06649-5
Melanoma GWAS Consortium 2018, ' Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways ', Nature Communications, vol. 9, no. 1, 4774 . https://doi.org/10.1038/s41467-018-06649-5
Duffy, D L, Zhu, G, Li, X, Sanna, M, Iles, M M, Jacobs, L C, Evans, D M, Yazar, S, Beesley, J, Law, M H, Kraft, P, Visconti, A, Taylor, J C, Lui, F, Wright, M J, Henders, A K, Bowdler, L, Glass, D, Ikram, A M, Uitterlinden, A G, Madden, P A, Heath, A C, Nelson, E C, Green, A C, Chanock, S, Barrett, J H, Brown, M A, Hayward, N K, MacGregor, S, Sturm, R A, Hewitt, A W, Lee, J E, Brossard, M, Moses, E K, Song, F, Kumar, R, Easton, D F, Pharoah, P D P, Swerdlow, A J, Kypreou, K P, Harland, M, Randerson-Moor, J, Akslen, L A, Andresen, P A, Avril, M F, Azizi, E, Scarrà, G B, Brown, K M & Dębniak, T & Smith, G D 2018, ' Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways ', Nature Communications, vol. 9, 4774 . https://doi.org/10.1038/s41467-018-06649-5

The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, United Kingdom, and United States, comprising a total of 52,506 phenotyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdc17d2ba531806731975db2a684a16
https://www.repository.cam.ac.uk/handle/1810/288608

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Autor: Law, M, Bishop, DT, Lee, JE, Brossard, M, Martin, NG, Moses, EK, Song, F, Barrett, JH, Kumar, R, Easton, DF, Pharoah, PDP, Swerdlow, AJ, Kypreou, KP, Taylor, JC, Harland, M, Randerson-Moor, J, Akslen, LA, Andresen, PA, Avril, MF, Azizi, E, Scarra, GB, Brown, KM, Debniak, T, Duffy, DL, Elder, DE, Fang, S, Friedman, E, Galan, P, Ghiorzo, P, Gillanders, EM, Goldstein, AM, Gruis, NE, Hansson, J, Helsing, P, Hocevar, M, Hoiom, V, Ingvar, C, Kanetsky, PA, Chen, WV, GenoMEL Consortium, Essen-Heidelberg Investigators, The SDH Study Group, Q-MEGA and QTWIN Investigators, AMFS Investigators, ATHENS Melanoma Study Group, Landi, MT, Lang, J, Lathrop, M, Lubinski, J, Mackie, RM, Mann, GJ, Molvern, A, Montgomery, GW, Novakovic, S, Olsson, H, Puig, S, Puig-Butille, JA, Qureshi, AA, Radford-Smith, GL, van der Stoep, N, van Doorn, R, Whiteman, DC, Craig, JE, Schadendorf, D, Simms, LA, Burdon, KP, Nyholt, DR, Pooley, KA, Orr, N, Stratigos, AJ, Cust, AE, Ward, SV, Hayward, NK, Han, J, Schulze, HJ, Dunning, AM, Newton-Bishop, JA, Demenais, F, Amos, CI, MacGregor, S, Iles, MM

Publikováno v: Nature genetics
Nature Genetics, 47(9), 987

© 2015 Nature America, Inc. All rights reserved.Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5f9ff31a6c8a038f83a3f0a16ecbf
https://hdl.handle.net/1887/107531

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.