Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Gilla Kaplan"'
Autor:
Afsal Kolloli, Santhamani Ramasamy, Ranjeet Kumar, Annuurun Nisa, Gilla Kaplan, Selvakumar Subbian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection involves pulmonary inflammation that can progress to acute respiratory distress syndrome, a primary cause of lung damage/fibrosis in patients with Coronavirus Dise
Externí odkaz:
https://doaj.org/article/7df68d239c564577bed46aaadc37938e
Autor:
Afsal Kolloli, Ranjeet Kumar, Pooja Singh, Anshika Narang, Gilla Kaplan, Alex Sigal, Selvakumar Subbian
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Kolloli et al. examine whether aggregation contributes to enhanced pathogenicity of Mycobacterium tuberculosis in a rabbit model of pulmonary infection. They demonstrate that aggregation increases the ability of M. tuberculosis to grow robustly and p
Externí odkaz:
https://doaj.org/article/9200d11ffb0243f6a25ca20a4c43df58
Autor:
Hylton E. Rodel, Isabella A. T. M. Ferreira, Carly G. K. Ziegler, Yashica Ganga, Mallory Bernstein, Shi-Hsia Hwa, Kievershen Nargan, Gila Lustig, Gilla Kaplan, Mahdad Noursadeghi, Alex K. Shalek, Adrie J. C. Steyn, Alex Sigal
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Mycobacterium tuberculosis (Mtb) bacilli readily aggregate. We previously reported that Mtb aggregates lead to phagocyte death and subsequent efficient replication in the dead infected cells. Here, we examined the transcriptional response of human mo
Externí odkaz:
https://doaj.org/article/2c87105ebf6a454b849cec67673a9715
Autor:
Ryan Dinkele, Sophia Gessner, Andrea McKerry, Bryan Leonard, Ronnett Seldon, Anastasia S Koch, Carl Morrow, Melitta Gqada, Mireille Kamariza, Carolyn R Bertozzi, Brian Smith, Courtney McLoud, Andrew Kamholz, Wayne Bryden, Charles Call, Gilla Kaplan, Valerie Mizrahi, Robin Wood, Digby F Warner
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009262 (2021)
Interrupting transmission is an attractive anti-tuberculosis (TB) strategy but it remains underexplored owing to our poor understanding of the events surrounding transfer of Mycobacterium tuberculosis (Mtb) between hosts. Determining when live, infec
Externí odkaz:
https://doaj.org/article/46d95117fb0e4fe0858db1757adc7738
Autor:
Ranjeet Kumar, Afsal Kolloli, Pooja Singh, Christopher Vinnard, Gilla Kaplan, Selvakumar Subbian
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2020)
Tuberculous meningitis (TBM) is the most devastating form of extrapulmonary Mycobacterium tuberculosis infection in humans. Severe inflammation and extensive tissue damage drive the morbidity and mortality of this manifestation of tuberculosis (TB).
Externí odkaz:
https://doaj.org/article/187e48c31f8d43eca3657a8cfd55f56c
Autor:
Pedro J. Esteves, Joana Abrantes, Hanna-Mari Baldauf, Lbachir BenMohamed, Yuxing Chen, Neil Christensen, Javier González-Gallego, Lorenzo Giacani, Jiafen Hu, Gilla Kaplan, Oliver T. Keppler, Katherine L. Knight, Xiang-Peng Kong, Dennis K. Lanning, Jacques Le Pendu, Ana Lemos de Matos, Jia Liu, Shuying Liu, Ana M. Lopes, Shan Lu, Sheila Lukehart, Yukari C. Manabe, Fabiana Neves, Grant McFadden, Ruimin Pan, Xuwen Peng, Patricia de Sousa-Pereira, Ana Pinheiro, Masmudur Rahman, Natalie Ruvoën-Clouet, Selvakumar Subbian, Maria Jesús Tuñón, Wessel van der Loo, Michael Vaine, Laura E. Via, Shixia Wang, Rose Mage
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-10 (2018)
Infectious disease: A leap forward for disease models Rabbits offer a powerful complement to rodents as a model for studying human immunology, disease pathology, and responses to infectious disease. A review from Pedro Esteves at the University of Po
Externí odkaz:
https://doaj.org/article/291d4ead9ccb4771a09c51a1a83754c4
Autor:
Selvakumar Subbian, Liana Tsenova, Jennifer Holloway, Blas Peixoto, Paul O'Brien, Véronique Dartois, Vikram Khetani, Jerome B. Zeldis, Gilla Kaplan
Publikováno v:
EBioMedicine, Vol 4, Iss C, Pp 104-114 (2016)
Objectives: Adjunctive host-directed therapy is emerging as a new potential approach to improve the outcome of conventional antimicrobial treatment for tuberculosis (TB). We tested the ability of a phosphodiesterase-4 inhibitor (PDE4i) CC-11050, co-a
Externí odkaz:
https://doaj.org/article/f6df5ed8b2964f1d815adcb0d25e25ee
Autor:
Selena Ferrian, Melinda Ross, Francesca Conradie, Shaheed Vally Omar, Nazir Ismail, Francesca Little, Gilla Kaplan, Dorothy Fallows, Clive M. Gray
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Identifying a blood circulating cellular biomarker that can be used to assess severity of disease and predict the time to culture conversion (TCC) in patients with multidrug resistant tuberculosis (MDR-TB) would facilitate monitoring response to trea
Externí odkaz:
https://doaj.org/article/280e6224004b4412b0fa398e8953f7ab
Autor:
Selena Ferrian, Claudia Manca, Sugnet Lubbe, Francesca Conradie, Nazir Ismail, Gilla Kaplan, Clive M Gray, Dorothy Fallows
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176660 (2017)
To identify plasma markers predictive of therapeutic response in patients with multidrug resistant tuberculosis (MDR-TB).Fifty HIV-negative patients with active pulmonary MDR-TB were analysed for six soluble analytes in plasma at the time of initiati
Externí odkaz:
https://doaj.org/article/0b574b0aeef14094ad2f1804e0d6eded
Autor:
Ivy - Rukasha, Halima Mohammed Said, Shaheed Vally Omar, Hendrik - Koornhoof, Andries W Dreyer, Alfred - Musekiwa, Harry Moultrie, Anwar A Hoosen, Gilla Kaplan, Dorothy Fallows, Nazir Ismail
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Abstract Treatment of tuberculosis (TB) and HIV co-infection is often complicated by drug-drug interactions between anti-mycobacterial and anti-retroviral (ARV) agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB regimens and is recomm
Externí odkaz:
https://doaj.org/article/bd88654063d447439ecf05c202046c71