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pro vyhledávání: '"Gill Tarrant"'
Autor:
Yogesh Mistry, Emily C. Liefooghe, David North, Isabelle Cludts, Cherry Edwards, Lucy Findlay, Robin Thorpe, Carl Dolman, Jane Robinson, David Eastwood, Stephen Poole, Adrian Bristow, Chris Bird, Susan J. Thorpe, Meenu Wadhwa, Tony Meager, P. Dilger, Gill Tarrant, Richard Stebbings, Bernard Fox
Publikováno v:
The Journal of Immunology. 179:3325-3331
The CD28-specific mAb TGN1412 rapidly caused a life-threatening “cytokine storm” in all six healthy volunteers in the Phase I clinical trial of this superagonist, signaling a failure of preclinical safety testing. We report novel in vitro procedu