Converging global crises are forcing the rapid adoption of disruptive changes in drug discovery

Autor: Gill Langley, J. Mark Treherne

Publikováno v: Drug Discovery Today

Spiralling research costs combined with urgent pressures from the Coronavirus 2019 (COVID-19) pandemic and the consequences of climate disruption are forcing changes in drug discovery. Increasing the predictive power of in vitro human assays and usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68f839758d7827be39b76b3d99a4dd9
https://doi.org/10.1016/j.drudis.2021.05.001

Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations

Autor: Brigitte Landesmann, Alysson R. Muotri, Elena Csernok, Tuula Heinonen, Lindsay Marshall, Hilde Van Esch, Kathrin Herrmann, Ian M. Adcock, Anja van de Stolpe, Catherine Willett, Francois Busquet, Troy Seidle, Christoph Giese, Fozia Noor, Martin Hofmann-Apitius, Kevin M. Crofton, Emily McIvor, Katrin Schutte, Grzegorz Woszczek, Gill Langley

Publikováno v: Langley, G R, Adcock, I M, Busquet, F, Crofton, K M, Csernok, E, Giese, C, Heinonen, T, Herrmann, K, Hofmann-Apitius, M, Landesmann, B, Marshall, L J, McIvor, E, Muotri, A R, Noor, F, Schutte, K, Seidle, T, van de Stolpe, A, Van Esch, H, Willett, C & Woszczek, G 2016, ' Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations ', DRUG DISCOVERY TODAY . https://doi.org/10.1016/j.drudis.2016.10.011
BASE-Bielefeld Academic Search Engine

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7431217f487a76bc25850daa7da4ce9b
https://pubmed.ncbi.nlm.nih.gov/27989722

Volunteer studies in pain research — Opportunities and challenges to replace animal experiments

Autor: Anthony K. P. Jones, N. Gordon, Turo Nurmikko, Penny Hawkins, Gill Langley, C. Bountra, C. K. Langley, Irene Tracey, Qasim Aziz

Publikováno v: NeuroImage. 42:467-473

Despite considerable research, effective and safe treatments for human pain disorders remain elusive. Understanding the biology of different human pain conditions and researching effective treatments continue to be dominated by animal models, some of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fe73a4fa257e115052fb94152684cc5
https://doi.org/10.1016/j.neuroimage.2008.05.030

Comment on 'Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research'

Autor: Gill Langley, D. A. Sakharov, Suzanne Fitzpatrick, Linda S. Birnbaum, John R. Fowle, Shuangqing Peng, Troy Seidle, Robert J. Kavlock, Maurice Whelan, Brett A. Lidbury, Alexander G. Tonevitsky, Alysson R. Muotri, Thales Trez, Christopher P. Austin, Hiroaki Kitano, Catherine Willett, John R. Bucher, Julia Fentem, Anja van de Stolpe, Anil K. Balapure

Publikováno v: Environmental Health Perspectives
Environmental health perspectives, vol 123, iss 11

The Brief Communication by Langley et al. was exceptional in its presentation of genomics and epigenomics, the discussion of the extrinsic and intrinsic causes of disease, and its outline of why a paradigm shift to human-based research is needed. I w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9fbbaaeed5501892f6ffc586fad5a8
https://pubmed.ncbi.nlm.nih.gov/27135756

3.9. Toxicokinetics and Metabolism

Autor: Pilar Prieto, Nigel Gensmantel, W. Steiling, Walter Pfaller, Peter Hoet, David E. Leahy, Vera Rogiers, M. Monshouwer, Bas J. Blaauboer, Andreas P. Freidig, Bernhard Ladstetter, Benoit Nemery, Greetje Elaut, Enrico Sabbioni, Johannes J.M. van de Sandt, Stuart J. Freeman, Nick Proctor, Annarita Meneguz, Geert Mannens, Sandra Coecke, Olavi Pelkonen, Vassilios M Kapoulas, Gill Langley, Amin Rostami-Hodjegan

Publikováno v: Alternatives to Laboratory Animals. 33:147-175

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::257d2fc2a803bc2e02d558e7979ee307
https://doi.org/10.1177/026119290503301s15