Výsledky vyhledávání - "Gill A. Webster"

Akademický článek

Innate signaling within the central nervous system recruits protective neutrophils

Autor: Reza Khorooshi, Joanna Marczynska, Ruthe Storgaard Dieu, Vian Wais, Christian Rønn Hansen, Stephanie Kavan, Mads Thomassen, Mark Burton, Torben Kruse, Gill A. Webster, Trevor Owens

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)

Abstract There is great interest in understanding how the central nervous system (CNS) communicates with the immune system for recruitment of protective responses. Infiltrating phagocytic monocytes and granulocytes are implicated in neuroinflammation

Externí odkaz: https://doaj.org/article/d60c0ab7320849308350694b265d8a2d

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Akademický článek

Evaluation of neurological changes in secondary progressive multiple sclerosis patients treated with immune modulator MIS416: results from a feasibility study

Autor: Gill A. Webster, Dalice A. Sim, Anne C. La Flamme, Nancy E. Mayo

Publikováno v: Pilot and Feasibility Studies, Vol 3, Iss 1, Pp 1-10 (2017)

Abstract Background While disease progression can be readily monitored in early stage relapsing multiple sclerosis (MS), it is more challenging for secondary progressive multiple sclerosis (SPMS). This advanced stage of disease has distinct pathophys

Externí odkaz: https://doaj.org/article/353ca39c4a114f2498eb4961800eccfc

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Akademický článek

MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu

Autor: Byung-Chul Lee, Nari Shin, Jin Young Lee, Insung Kang, Jae-Jun Kim, Seung Eun Lee, Soon Won Choi, Gill A. Webster, Kyung-Sun Kang

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Human adult stem cells, including umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), have recently been considered a promising alternative treatment for inflammatory bowel disease (IBD) due to their unique immunomodulatory properties an

Externí odkaz: https://doaj.org/article/49b41e2c9d6146c3816f28a2f5cf67b9

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First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors

Autor: Naozumi Harada, Katsunori Uchida, Takeshi Sasaki, Yoshiki Sugimura, Yasutaka Tono, Gill A Webster, Naoyuki Katayama, Shinichi Kageyama, Hiroshi Shiku, Toshiro Mizuno, Yoshihiro Miyahara, Hideki Kanda, Mikiya Ishihara, Eiichi Sato, Taizo Shiraishi, Yasuhide Hori, Norihito Soga, Hiroaki Ikeda, Daisuke Muraoka

Publikováno v: Cancer Immunology, Immunotherapy

Cholesteryl pullulan (CHP) is a novel antigen delivery system. CHP and New York esophageal squamous cell carcinoma 1 (NY-ESO-1) antigen complexes (CHP-NY-ESO-1) present multiple epitope peptides to the MHC class I and II pathways. Adjuvants are essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3477f6e7567b8e1a8173e128b6e3de91
http://europepmc.org/articles/PMC7113205

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Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer

Autor: Ruea-Yea Huang, Brian D. Lichty, Amit A. Lugade, Cheryl Eppolito, Sebastiano Battaglia, Kunle Odunsi, Anthony Miliotto, Gill A. Webster, Kyle B Stephenson, AJ Robert McGray, Mukund Seshadri, Danuta Kozbor

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Journal for Immunotherapy of Cancer

Background Cancer immunotherapies are emerging as promising treatment strategies for ovarian cancer patients that experience disease relapse following first line therapy. As such, identifying strategies to bolster anti-tumor immunity and limit immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9739c284b3c05ddb8c43620119b27281
http://link.springer.com/article/10.1186/s40425-019-0641-x

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MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells

Autor: Michael R. Eccles, Francesco Mainini, Gill A. Webster, David S. Larsen, Sarah L. Young

Publikováno v: Nucleic Acid Therapeutics

MIS416 is a microparticulate formulation derived from propionibacterium acnes cell wall skeletons with intrinsic adjuvant activity. Conjugates of MIS416-SS-peptide containing a disulfide linkage facilitate the cytoplasmic delivery and release of pept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c314fed785cd2bff207b0f034326761
https://doi.org/10.1089/nat.2017.0695

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Innate IFN-γ ameliorates experimental autoimmune encephalomyelitis and promotes myeloid expansion and PDL-1 expression

Autor: Faith Leonard, Gill A. Webster, Madeleine P. J. White, Anne C. La Flamme

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

The innate immune system plays a central role in the immune-mediated pathology of multiple sclerosis, and is a therapeutic target for progressive disease. Recently, it has been demonstrated that MIS416, a novel immunomodulatory microparticle that act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9c9b20678269d346f32617322a7da6
https://pubmed.ncbi.nlm.nih.gov/29321652

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First-in-human phase I clinical trial of NY-ESO-1 protein cancer vaccine with a novel adjuvant MIS416, NOD2 and TLR9 stimulant, for patients with NY-ESO-1 expressing solid tumors

Autor: Katsunori Uchida, Takeshi Sasaki, Naoyuki Katayama, Yasutaka Tono, Hiroaki Ikeda, Yoshihiro Miyahara, Eiichi Sato, Norihito Soga, Shinichi Kageyama, Taizo Shiraishi, Yoshiki Sugimura, Gill A Webster, Toshiro Mizuno, Naozumi Harada, Hiroshi Shiku, Mikiya Ishihara, Yasuhide Hori, Hideki Kanda

Publikováno v: Journal of Clinical Oncology. 36:e15176-e15176

e15176Background: Complexes of Cholesteryl pullulan and NY-ESO-1 antigen (CHP-NY-ESO-1) present multiple epitope peptides to both the MHC class I and class II pathways. MIS416 is a non-toxic microp...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ded85d0c4832ff717aa532060efef096
https://doi.org/10.1200/jco.2018.36.15_suppl.e15176

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Bridging Small Molecules to Modified Bacterial Microparticles Using a Disulphide Linkage: MIS416 as a Cargo Delivery System

Autor: Michael R. Eccles, Sarah L. Young, Francesco Mainini, Gill A. Webster, David S. Larsen

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145403 (2015)
PLoS ONE

MIS416 is an intact minimal cell wall skeleton derived from Proprionibacterium acnes that is phagocytosed by antigen presenting cells, including dendritic cells (DCs). This property allows MIS416 to be exploited as a vehicle for the delivery of pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc170b243060f863fad1f84964c8958
http://europepmc.org/articles/PMC4687933?pdf=render

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