Phase I safety and immunogenicity evaluation of ADVAX, a Multigenic, DNA-based Clade C/B' HIV-1 candidate vaccine

Autor: Hurley, A, Lombardo, A, Schlesinger, SJ, Vasan, S, Huang, Y, Smith, C, Cox, J, Keefer, MC, Boyle, R, Dally, L, Gilmour, J, Fast, P, Ho, DD, Chen, Z, Ho, M, Schmidt, C, Clark, L, Markowitz, M, Sayeed, E, Dugin, D, Gill, DK, Than, S, Adesanya, P, Bunce, C, Seamons, L, Boaz, M, Song, Y

BACKGROUND: We conducted a Phase I dose escalation trial of ADVAX, a DNA-based candidate HIV-1 vaccine expressing Clade C/B' env, gag, pol, nef, and tat genes. Sequences were derived from a prevalent circulating recombinant form in Yunnan, China, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______961::e06000babb62cc308351bfa932f97a90
http://hdl.handle.net/10722/129304

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Broad HIV epitope specificity and viral inhibition induced by multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults.

Autor: Kopycinski J; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Hayes P; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Ashraf A; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Cheeseman H; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Lala F; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Czyzewska-Khan J; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Spentzou A; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Gill DK; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Keefer MC; University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America., Excler JL; IAVI, New York, New York, United States of America., Fast P; IAVI, New York, New York, United States of America., Cox J; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom., Gilmour J; International AIDS Vaccine Initiative (IAVI), Human Immunology Laboratory, Imperial College, London, United Kingdom.

Publikováno v: PloS one [PLoS One] 2014 Mar 07; Vol. 9 (3), pp. e90378. Date of Electronic Publication: 2014 Mar 07 (Print Publication: 2014).

Measuring human T cell responses in blood and gut samples using qualified methods suitable for evaluation of HIV vaccine candidates in clinical trials.

Autor: Kaltsidis H; International AIDS Vaccine Initiative Human Immunology Laboratory (IAVI HIL), London, UK., Cheeseman H, Kopycinski J, Ashraf A, Cox MC, Clark L, Anjarwalla I, Dally L, Bergin P, Spentzou A, Higgs C, Gotch F, Gazzard B, Gomez R, Hayes P, Kelleher P, Gill DK, Gilmour J

Publikováno v: Journal of immunological methods [J Immunol Methods] 2011 Jul 29; Vol. 370 (1-2), pp. 43-54. Date of Electronic Publication: 2011 Jun 12.