Peripherally administered oxytocin modulates latent inhibition in a manner consistent with antipsychotic drugs

Autor: Paul D. Shilling, Gilia Melendez, M. Maisel, David Feifel, J. Winfield, J. Hillman

Publikováno v: Behavioural Brain Research. 278:424-428

Peripherally administered oxytocin (OT) has produced antipsychotic drug (APD)-like effects in animal tests that are predictive of APD efficacy. However, these effects have mainly been demonstrated using animal models of schizophrenia-like deficits in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798e3ff1a74f35353c288ffe8b6a5736
https://doi.org/10.1016/j.bbr.2014.10.023

Further characterization of the predictive validity of the Brattleboro rat model for antipsychotic efficacy

Autor: Gilia Melendez, Paul D. Shilling, David Feifel

Publikováno v: Journal of Psychopharmacology. 25:836-841

Our laboratory and others have reported that Brattleboro (BRAT) rats, a Long Evans (LE) strain with a single gene mutation, have inherent deficits in prepulse inhibition (PPI) homologous to those observed in schizophrenia patients and that these defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddff54e9e568e6a68d95da44da0b737
https://doi.org/10.1177/0269881110388327

The Brattleboro Rat Displays a Natural Deficit in Social Discrimination That Is Restored by Clozapine and A Neurotensin Analog

Autor: Philip Y. T. Liu, David Feifel, Joseph R. Goldenberg, Sharon Mexal, Paul D. Shilling, Gilia Melendez

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 34, iss 8
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Cognitive deficits in schizophrenia are a major source of dysfunction for which more effective treatments are needed. The vasopressin-deficient Brattleboro (BRAT) rat has been shown to have several natural schizophrenia-like deficits, including impai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5b58e8bf420623bebf39881dc4c276
https://doi.org/10.1038/npp.2009.15

The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats

Autor: Kristianne Priebe, Paul D. Shilling, David Feifel, Gilia Melendez

Publikováno v: Behavioural Brain Research. 181:278-286

We previously reported that vasopressin deficient Brattleboro (BRAT) rats exhibit deficits in prepulse inhibition (PPI) of the startle reflex that are consistent with PPI deficits exhibited by patients with schizophrenia and other neuropsychiatric di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a05e5528ea1bba43c4653f7f9c05f3b
https://doi.org/10.1016/j.bbr.2007.04.020

Reversal of Sensorimotor Gating Deficits in Brattleboro Rats by Acute Administration of Clozapine and a Neurotensin Agonist, but not Haloperidol: a Potential Predictive Model for Novel Antipsychotic Effects

Autor: Gilia Melendez, David Feifel, Paul D. Shilling

Publikováno v: Neuropsychopharmacology. 29:731-738

Prepulse inhibition (PPI) of acoustic startle is decreased in unmedicated schizophrenia patients and similar deficits can be induced in rats through pharmacological, environmental, or neuroanatomical manipulations. Recently, we reported that Brattleb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce737dd9db82e38b1f7fcc542a54eb10
https://doi.org/10.1038/sj.npp.1300378