Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains.

Autor: Girdhar K; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kiran.girdhar@mssm.edu.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kiran.girdhar@mssm.edu.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kiran.girdhar@mssm.edu., Hoffman GE; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bendl J; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rahman S; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dong P; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liao W; New York Genome Center, New York, NY, USA., Hauberg ME; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Sloofman L; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brown L; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Devillers O; 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Publikováno v: Nature neuroscience [Nat Neurosci] 2022 Apr; Vol. 25 (4), pp. 474-483. Date of Electronic Publication: 2022 Mar 24.

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia.

Autor: Bohan Zhu, Ainsworth, Richard I., Zengmiao Wang, Zhengzhi Liu, Sierra, Salvador, Chengyu Deng, Callado, Luis F., Meana, J. Javier, Wei Wang, Chang Lu, González-Maeso, Javier

Publikováno v: eLife; 4/22/2024, p1-29, 29p

Cohesin-mediated loop anchors confine the locations of human replication origins.

Autor: Emerson DJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhao PA; Department of Biological Science, Florida State University, Tallahassee, FL, USA., Cook AL; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Barnett RJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Klein KN; Department of Biological Science, Florida State University, Tallahassee, FL, USA., Saulebekova D; Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, Paris, France., Ge C; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhou L; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Simandi Z; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Minsk MK; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Titus KR; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang W; Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, Paris, France., Gong W; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhang D; Children's Hospital of Pennsylvania, Philadelphia, PA, USA., Yang L; University of Massachusetts Chan Medical School, Worcester, MA, USA., Venev SV; University of Massachusetts Chan Medical School, Worcester, MA, USA., Gibcus JH; University of Massachusetts Chan Medical School, Worcester, MA, USA., Yang H; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Sasaki T; San Diego Biomedical Research Institute, San Diego, CA, USA., Kanemaki MT; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima, Japan.; Department of Genetics, The Graduate University for Advanced Studies (Sokendai), Mishima, Japan., Yue F; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Dekker J; University of Massachusetts Chan Medical School, Worcester, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Chen CL; Institut Curie, PSL Research University, CNRS UMR3244, Dynamics of Genetic Information, Sorbonne Université, Paris, France., Gilbert DM; Department of Biological Science, Florida State University, Tallahassee, FL, USA.; San Diego Biomedical Research Institute, San Diego, CA, USA., Phillips-Cremins JE; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. jcremins@seas.upenn.edu.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jcremins@seas.upenn.edu.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jcremins@seas.upenn.edu.; New York Stem Cell Foundation Robertson Investigator, New York, NY, USA. jcremins@seas.upenn.edu.

Publikováno v: Nature [Nature] 2022 Jun; Vol. 606 (7915), pp. 812-819. Date of Electronic Publication: 2022 Jun 08.

The role of structural variations in Alzheimer's disease and other neurodegenerative diseases.

Autor: Hui Wang, Li-San Wang, Schellenberg, Gerard, Wan-Ping Lee

Publikováno v: Frontiers in Aging Neuroscience; 2/8/2023, Vol. 15, p1-13, 13p