Immunohistochemical, ultrastructural and functional analysis of axonal regeneration through peripheral nerve grafts containing Schwann cells expressing BDNF, CNTF or NT3.

Autor: Maria João Godinho, Lip Teh, Margaret A Pollett, Douglas Goodman, Stuart I Hodgetts, Iain Sweetman, Mark Walters, Joost Verhaagen, Giles W Plant, Alan R Harvey

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e69987 (2013)

We used morphological, immunohistochemical and functional assessments to determine the impact of genetically-modified peripheral nerve (PN) grafts on axonal regeneration after injury. Grafts were assembled from acellular nerve sheaths repopulated ex

Externí odkaz: https://doaj.org/article/58407f353a784a218481e7d422189d6b

Contributors

Autor: Ana A. Aldana, Morgan R. Alexander, Anthony Atala, Stephen F. Badylak, Matthew B. Baker, Jurica Bauer, Cameron Black, Sharan Bobbala, Mats Brittberg, Gary A. Brook, Fraser Buchanan, Aurélie Carlier, Saray Chen, Evan Claes, Smadar Cohen, John Connelly, Matthew J. Dalby, Paul D. Dalton, Jonathan I. Dawson, Jan de Boer, Tim Desmet, Hannah Donnelly, Filip Donvil, Jenna L. Dziki, Dominik Egger, Miriam Filippi, Marius Gensler, David Gibbs, Susan Gibbs, Rosalind Hannen, Jan Hansmann, Alan R. Harvey, Tommy Heck, Marietta Herrmann, Andrew L. Hook, Jeffrey A. Hubbell, Dietmar W. Hutmacher, Clara Grace Hynes, Johan Joly, Adam M. Jorgensen, Janos Kanczler, Marcel Karperien, Cornelia Kasper, Candace L. Kerr, Kristopher A. Kilian, Sebastian Kreß, Vanessa LaPointe, Matthias W. Laschke, Anders Lindahl, Ricardo Londono, Frank P. Luyten, Marina Marechal, Mikaël M. Martino, Malcolm Moos, Lorenzo Moroni, Emily Morra, Simon Myers, Sabrina Nebel, Minghao Nie, David R. Nisbet, Kelly L. O'Neill, Nkemcho Ojeh, Richard OC. Oreffo, Martin Oudega, Robert Passier, Ana Paula Pêgo, Mark F. Pittenger, Giles W. Plant, Jeffrey J. Rice, Bernard A.J. Roelen, Anaïs Schaschkow, Arnaud Scherberich, Jan Schrooten, Evan A. Scott, Brian M. Sicari, Maarten Sonnaert, Thomas Später, Shoji Takeuchi, Biranche Tandon, Rahul Tare, Roman Truckenmüller, Monica Tsimbouri, Jorge Alfredo Uquillas, Dieter Van Assche, Steven Vermeulen, Sophie Verrier, Pamela Walsh, David A. Winkler

Publikováno v: Tissue Engineering ISBN: 9780128244593

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b428686cabf006087fc936a5d12d8d57
https://doi.org/10.1016/b978-0-12-824459-3.01002-7

Human Deep Cortical Neurons Promote Regeneration and Recovery After Cervical Spinal Cord Injury

Autor: Vanessa M. Doulames, James M. Weimann, Giles W. Plant

Cervical spinal cord injuries (SCI) sever and permanently disrupt sensorimotor neural circuitry. Restoring connectivity within the damaged circuitry is critical to improving function. Herein we report robust regeneration of severed neural circuitry i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e5c2132ce994856e0caaa15c71574dc
https://doi.org/10.1101/2021.08.11.455948

Regeneration of adult rat sensory and motor neuron axons through chimeric peroneal nerve grafts containing donor Schwann cells engineered to express different neurotrophic factors

Autor: Margaret A. Pollett, Alan R. Harvey, Vidya Krishnan, Jonas L. Staal, Giles W. Plant, Douglas P. Goodman, Maria João Godinho, Joost Verhaagen, Lip Teh, Stuart I. Hodgetts

Publikováno v: Experimental Neurology, 330. Academic Press

Large peripheral nerve (PN) defects require bridging substrates to restore tissue continuity and permit the regrowth of sensory and motor axons. We previously showed that cell-free PN segments repopulated ex vivo with Schwann cells (SCs) transduced w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f10c51561df6e874ba0547532b7a43
https://doi.org/10.1016/j.expneurol.2020.113355

Designer, injectable gels to prevent transplanted Schwann cell loss during spinal cord injury therapy

Autor: Vanessa M. Doulames, Zachary A Medress, Riley A. Suhar, Michael J. Kratochvil, Sarah C. Heilshorn, Laura M. Marquardt, Giles W. Plant, Alice T. Wang, Karen Dubbin

Publikováno v: Science Advances

An injectable gel improves cell transplantation therapy for spinal cord injury.
Transplantation of patient-derived Schwann cells is a promising regenerative medicine therapy for spinal cord injuries; however, therapeutic efficacy is compromised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380ec124198b1a9cd282a385329e24e6
https://pubmed.ncbi.nlm.nih.gov/32270042