Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Giles S.H. Yeo"'
Autor:
Maki Asami, Brian Y.H. Lam, Martin Hoffmann, Toru Suzuki, Xin Lu, Naoko Yoshida, Marcella K. Ma, Kara Rainbow, Miodrag Gužvić, Matthew D. VerMilyea, Giles S.H. Yeo, Christoph A. Klein, Anthony C.F. Perry
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112023- (2023)
Summary: At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing and profile remain elusive i
Externí odkaz:
https://doaj.org/article/58b7a14aaceb4f2b84375d76e14ddecf
Autor:
Stefan Wagner, Daniel I. Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian Y.H. Lam, Georgina K.C. Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M. Gribble, Pablo B. Martinez de Morentin, Giles S.H. Yeo, Stefan Trapp, Lora K. Heisler
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101665- (2023)
Objective: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R; e.g
Externí odkaz:
https://doaj.org/article/a7f4d6b4357e4a4d9af68e183e845a6f
Autor:
Georgina K.C. Dowsett, Brian Y.H. Lam, John A. Tadross, Irene Cimino, Debra Rimmington, Anthony P. Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S.H. Yeo
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101240- (2021)
Objective: The area postrema (AP) and nucleus tractus solitarius (NTS) located in the hindbrain are key nuclei that sense and integrate peripheral nutritional signals and consequently regulate feeding behaviour. While single-cell transcriptomics have
Externí odkaz:
https://doaj.org/article/b936b51bf93846b983c2dbc7b36f2da8
Autor:
Sara Kohnke, Sophie Buller, Danae Nuzzaci, Katherine Ridley, Brian Lam, Helena Pivonkova, Marie A. Bentsen, Kimberly M. Alonge, Chao Zhao, John Tadross, Staffan Holmqvist, Takahiro Shimizo, Hannah Hathaway, Huiliang Li, Wendy Macklin, Michael W. Schwartz, William D. Richardson, Giles S.H. Yeo, Robin J.M. Franklin, Ragnhildur T. Karadottir, David H. Rowitch, Clemence Blouet
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109362- (2021)
Summary: The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy bala
Externí odkaz:
https://doaj.org/article/5e36423c8b584650a2ec34b1447ad29b
Autor:
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101206- (2021)
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more
Externí odkaz:
https://doaj.org/article/214ce1a22d184bb08a8fd34984c1b999
Autor:
Jonathan R. Wray, Alison Davies, Charlotte Sefton, Tiffany-Jayne Allen, Antony Adamson, Philip Chapman, Brian Y.H. Lam, Giles S.H. Yeo, Anthony P. Coll, Erika Harno, Anne White
Publikováno v:
Molecular Metabolism, Vol 26, Iss , Pp 5-17 (2019)
Objective: Glucocorticoids (GCs) are widely prescribed medications that are well recognized to cause adverse metabolic effects including hyperphagia, obesity, and hyperglycemia. These effects have been recapitulated in a murine model of GC excess, an
Externí odkaz:
https://doaj.org/article/15bf380476bb40b2a665b989ba63e358
Autor:
Ran Joo Choi, Siti Zuraidah Mohamad Zobir, Ben Alexander-Dann, Nitin Sharma, Marcella K.L. Ma, Brian Y.H. Lam, Giles S.H. Yeo, Weidong Zhang, Tai-Ping Fan, Andreas Bender
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Shexiang Baoxin Pill (SBP) is an oral formulation of Chinese materia medica for the treatment of angina pectoris. It displays pleiotropic roles in protecting the cardiovascular system. However, the mode of action of SBP in promoting angiogenesis, and
Externí odkaz:
https://doaj.org/article/a5c2ff09462547569d33c6de5b8d9ab9
Autor:
Saira Hameed, Michael Patterson, Waljit S. Dhillo, Sofia A. Rahman, Yue Ma, Christopher Holton, Apostolos Gogakos, Giles S.H. Yeo, Brian Y.H. Lam, Joseph Polex-Wolf, Wiebke Fenske, Jimmy Bell, Jelena Anastasovska, Jacques Samarut, Stephen R. Bloom, J.H. Duncan Bassett, Graham R. Williams, James V. Gardiner
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2202-2209 (2017)
The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms that regulate appetite and body weight will provide the rationale for the design of anti-obesity therapies. Thyroid hormones play a key role in metabo
Externí odkaz:
https://doaj.org/article/d368c488aef54187b714d5c151f12af6
Autor:
Brian Y.H. Lam, Irene Cimino, Joseph Polex-Wolf, Sara Nicole Kohnke, Debra Rimmington, Valentine Iyemere, Nicholas Heeley, Chiara Cossetti, Reiner Schulte, Luis R. Saraiva, Darren W. Logan, Clemence Blouet, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo
Publikováno v:
Molecular Metabolism, Vol 6, Iss 5, Pp 383-392 (2017)
Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture. Methods: Using single cell RNA sequencin
Externí odkaz:
https://doaj.org/article/420acb59b9a143a7bd33fe340d1f7af7
Autor:
Pierre Larraufie, Geoffrey P. Roberts, Anne K. McGavigan, Richard G. Kay, Joyce Li, Andrew Leiter, Audrey Melvin, Emma K. Biggs, Peter Ravn, Kathleen Davy, David C. Hornigold, Giles S.H. Yeo, Richard H. Hardwick, Frank Reimann, Fiona M. Gribble
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1399-1408.e6 (2019)
Summary: Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are wi
Externí odkaz:
https://doaj.org/article/979cdd19068a475e993981d0880f746c