Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Giles Robert Gordon"'
Publikováno v:
Tetrahedron. 71:7367-7385
Reactions of N-methyl- and N-ethyl-nitrilium salts with indole and pyrrole and their derivatives yield imines or imine salts in good yields. The related imines are obtained from the salts after careful basification and hydrolysis of the imine salts o
Publikováno v:
ChemInform. 47
Reactions of N-methyl- and N-ethyl-nitrilium salts with indole and pyrrole and their derivatives yield imines or imine salts in good yields. The related imines are obtained from the salts after careful basification and hydrolysis of the imine salts o
Autor:
Norman Lewis, Steve O. Moore, Michael Urquhart, Bernie M. Choudary, Florence Jovic, Giles Robert Gordon
Publikováno v:
Organic Process Research & Development. 16:1927-1939
A synthesis of the pleuromutilin antibiotic SB-268091 is described which includes a new and improved route to the quinuclidine-4-thiol ligand. This chemistry has been run on multikilo scale and involved a reductive double debenzylation using sodium i
Autor:
Giles Robert Gordon, Lewis Norman John, Latifa H. Youssef, Michael Urquhart, Sasse Michael John, Quick John Kirby
Publikováno v:
Tetrahedron. 56:4531-4537
The novel regiospecific and general reduction of 5-benzylidene-2,4-thiazolidinediones and 5-benzylidene-4-oxo-2-thiazolidinethiones to the corresponding 5-benzyl derivatives has been accomplished using lithium borohydride in pyridine and tetrahydrofu
Autor:
Alan Negus, M. Whiter, and Timothy C. Walsgrove, Simon Howie, John D. Hayler, Paul Oxley, Giles Robert Gordon
Publikováno v:
Organic Process Research & Development. 2:3-9
Two plant syntheses of ropinirole {4-[2-(di-n-propylamino)ethyl]-1,3-dihydro-2H-indolin-2-one hydrochloride, SK&F-101468-A} using the ferric chloride mediated cyclisation of β-nitrostyrenes to form...
Autor:
Mann Inderjit Singh, Vance J. Novack, John D. Hayler, Graham R. Geen, Paul W. Oxley, S. L. B. Howie, Johnson Graham, Giles Robert Gordon, Smith Neil, Quick John Kirby, Trevor John Grinter
Publikováno v:
Synthetic Communications. 27:1065-1073
A direct and high yielding route to 2-(5-tetrazolyl)benzopyran-4-ones 1, including pranlukast 1a is described. This involves the Claisen condensation reaction between the relevant hydroxyacetophenone 2 and the ethyl ester of tetrazole-2-carboxylic ac
Publikováno v:
ChemInform. 23
Autor:
R. E. Dagger, Timothy Charles Walsgrove, A. Negus, Giles Robert Gordon, S. E. Walsh, John D. Hayler, S. L. B. Howie, Joseph M. Fortunak, A. Mastrocola, P. W. Oxley
Publikováno v:
ChemInform. 26
Autor:
Paul W. Oxley, Smith Neil, Giles Robert Gordon, John D. Hayler, Vance J. Novack, Johnson Graham, Trevor John Grinter, Quick John Kirby, S. L. B. Howie, Graham R. Geen, Mann Inderjit Singh
Publikováno v:
ChemInform. 28
A direct and high yielding route to 2-(5-tetrazolyl)benzopyran-4-ones 1, including pranlukast 1a is described. This involves the Claisen condensation reaction between the relevant hydroxyacetophenone 2 and the ethyl ester of tetrazole-2-carboxylic ac
Autor:
Giles Robert Gordon, Timothy Charles Walsgrove, A. Negus, P. W. Oxley, M. Whiter, S. L. B. Howie, John D. Hayler
Publikováno v:
ChemInform. 29