Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Giles Pergl-Wilson"'
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085970df8f01140213c017be9fe8aaa7
https://doi.org/10.1158/1535-7163.c.6532217
https://doi.org/10.1158/1535-7163.c.6532217
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b69a6d0bf7df52af3de6589e9ad5e0
https://doi.org/10.1158/1535-7163.22486067.v1
https://doi.org/10.1158/1535-7163.22486067.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 3C from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c866c66e69073421c00311e11a606c
https://doi.org/10.1158/1535-7163.22486061.v1
https://doi.org/10.1158/1535-7163.22486061.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Table 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af932823949bf9230e37a31da950e4b
https://doi.org/10.1158/1535-7163.22486052.v1
https://doi.org/10.1158/1535-7163.22486052.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 2 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e805e180fd509a9ec2ce653e2f2de8e
https://doi.org/10.1158/1535-7163.22486064
https://doi.org/10.1158/1535-7163.22486064
Autor:
Giles Pergl-Wilson, Anna King, Julia Hatto, Henry Danahay, David Andrew Sandham, Mariana Oana Popa, Emily Stanley, Parmjit Bahra, Urs Baettig, Rebecca Butler, Brian Cox, Lightfoot Megan, Christopher J. Page, Alice Young, Paul J. Groot-Kormelink, Trixie Wagner, Swarupa Kulkarni, Glyn Hughes, Edward Charles Hall, David J. Rowlands, Lee Edwards, Atwood K. Cheung, Matthew Spendiff, Tom Sharp, Kamlesh Bala, Stephen Paul Collingwood, Hazel Watson, Julia Koehler, Oliver Ross Steward, Anne-Lise Glotin, Penny Wright, Cara E. Brocklehurst, Ulrike Glaenzel, Ian Nicholls, Richard I. Robinson, Roger J. Taylor, Catherine Howsham, Brian Everatt, Darren Le Grand, Hedaythul Choudhury, Gareth Williams, Emma Budd, Martin Gosling, Pamela Tranter
Publikováno v:
Journal of Medicinal Chemistry. 64:7241-7260
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795fc619db3aa5e70b7fe14aeddd53fe
https://doi.org/10.1021/acs.jmedchem.1c00343
https://doi.org/10.1021/acs.jmedchem.1c00343
Autor:
Adrian Folkes, Alexis De Haven Brandon, Sonal Patel, Francesca Di Stefano, Letitia Lensun, Peter Sheldrake, Alexander Zhyvoloup, Irina Chuckowree, Stephen J. Shuttleworth, Suzanne A. Eccles, Melanie Valenti, Sonia Alix, Paul A. Clarke, Nahid Saghir, Nan Chi Wan, Paul Workman, Alan T. Henley, Edward McDonald, Gary Box, Anthony Robson, Giles Pergl-Wilson, Florence I. Raynaud, Angela Hayes, Sharon Gowan
Publikováno v:
Molecular Cancer Therapeutics. 8:1725-1738
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53d2116412a4ec9393dec9e50aa6961
https://doi.org/10.1158/1535-7163.mct-08-1200
https://doi.org/10.1158/1535-7163.mct-08-1200
Autor:
Suzanne A. Eccles, Pauline Moore, Lori Friedman, Paul A. Clarke, Stewart J. Baker, Olivero Alan G, Gary Box, Anthony Robson, Paul Workman, Khatereh Ahmadi, Laurent Salphati, Nahid Saghir, Giles Pergl-Wilson, Irina Chuckowree, Mark H. Ultsch, Wendy K. Alderton, Marketa Zvelebil, Florence I. Raynaud, Sukhjit Sohal, Arumugam Kugendradas, Christian Wiesmann, Adrian Folkes, Sonal Patel, Letitia Lensun, Angela Hayes, Timothy Hancox, Stephen J. Shuttleworth, Alexander Zhyvoloup, Heidi J.A. Wallweber, Paul Depledge, Melanie Valenti, Sonia Alix, Nan Chi Wan, Jodie Pang
Publikováno v:
Journal of Medicinal Chemistry. 51:5522-5532
Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/ Akt signaling pathway in a wide variety of tumors. A series of thieno[3,2-d]pyrimidine derivatives were prepared and evaluated as inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de0e3ae091925e99a0f90135c014d5f
https://doi.org/10.1021/jm800295d
https://doi.org/10.1021/jm800295d
Autor:
Patrick Waite, Emma Hurley, Patricia Balaresque, Turi E. King, Giles Pergl-Wilson, Abigail L. Jones, Georgina R. Bowden, Stephen E. Harding, Mark G. Thomas, Judith Jesch, Mark A. Jobling, Andrew C. Lee, Stephen J. Roberts, Ziff Hansen
The genetic structures of past human populations are obscured by recent migrations and expansions, and can been observed only indirectly by inference from modern samples. However, the unique link between a heritable cultural marker, the patrilineal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63985dcb2d5231b113cb6a29876820c2
https://europepmc.org/articles/PMC2628767/
https://europepmc.org/articles/PMC2628767/
Autor:
Bowden, Georgina R., Balaresque, Patricia, King, Turi E., Hansen, Ziff, Lee, Andrew C., Pergl-Wilson, Giles, Hurley, Emma, Roberts, Stephen J., Waite, Patrick, Jesch, Judith, Jones, Abigail L., Thomas, Mark G., Harding, Stephen E., Jobling, Mark A.
Publikováno v:
Molecular Biology & Evolution; Feb2008, Vol. 25 Issue 2, p301-309, 9p