On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

Autor: Cole MA; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Abd Jamil AH; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Heather LC; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Murray AJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Sutton ER; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Slingo M; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Sebag-Montefiore L; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;, Tan SC; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Aksentijević D; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;, Gildea OS; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Stuckey DJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Yeoh KK; Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom; and., Carr CA; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Evans RD; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Aasum E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Schofield CJ; Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom; and., Ratcliffe PJ; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Neubauer S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;, Robbins PA; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;, Clarke K; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; kieran.clarke@dpag.ox.ac.uk.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2016 Aug; Vol. 30 (8), pp. 2684-97. Date of Electronic Publication: 2016 Apr 21.