Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gildas Prie"'
Publikováno v:
Cancers, Vol 16, Iss 2, p 461 (2024)
Extensive research is underway to develop new therapeutic strategies to counteract therapy resistance in cancers. This review presents various strategies to achieve this objective. First, we discuss different vectorization platforms capable of releas
Externí odkaz:
https://doaj.org/article/97b903ae27b74a1297f5b54e1324af79
Autor:
Abderrahman El Bouakher, Mohamed Akssira, Marie-Claude Viaud-Massuard, Mina Aadil, Gildas Prie
Publikováno v:
Tetrahedron. 69:5086-5091
An efficient synthesis leading to novel 2,4-disubstituted 3H-pyrido[3,2-e][1,4]diazepin-5-ones and 2,4-disubstituted 3H-pyrido[2,3-e][1,4]diazepin-5-ones derivatives is presented, using the condensation of ethyl 2-(benzylamino)acetate or ethyl 2-(4-m
Autor:
Mina Aadil, Ahmed El Hakmaoui, Said Lazar, Marie-Claude Viaud-Massuard, Mohamed Akssira, Abderrahman El Bouakher, Gildas Prie
Publikováno v:
Tetrahedron Letters. 53:6401-6405
An efficient method for synthesizing new pyrido[2,3-e]pyrrolo[1,2-a][1,4]diazepine-5,10-dione derivatives starting from l -proline methyl ester and 2-aminonicotinic acid is presented. This method employs Pd-catalyzed cross-coupling reaction on the co
Autor:
Mina Aadil, Said Lazar, Abderrahman El Bouakher, Mohamed Akssira, Marie-Claude Viaud-Massuard, Gildas Prie
Publikováno v:
Tetrahedron. 68:9572-9577
A novel methodology has been developed for the efficient synthesis of 1,4-pyridopyrrolodiazepine derivatives. The key reaction is the bromination under mild conditions by NBS of compounds resulting via peptide coupling of l -proline methyl ester with
Autor:
Pascal, Didier, Éric, Peyrin, Nicolas, Willand, Serge, Battu, Gaëlle, Bégaud, Aurélie, Bourderioux, Éric, Cavalli, Christian, Cavé, Igor, Clarot, Dominique, Clédat, Raphaël, Delépée, Anne, Denuziere, Fatima, El Garah, Marion, Flipo, Catherine, Foulon, Béatrice, Gargadennec, Karen, Gaudin, Jean-François, Goossens, Christine, Herrenknecht, Nicolas, Huang, Petter, Jordheim Lars, Julie, Karpenko, François-Xavier, Legrand, Christelle, Machon, Pascal, Marchand, Alain, Nicolay, Isabelle, Ourliac-Garnier, Catherine, Perrin, Marine, Peuchmaur, Laurence, Poirier, Gildas, Prié, Christophe, Rochais, Marc, Since, Martin, Soucé, Yen, Vo Hoang, Christelle, Wisniewski
Publikováno v:
In Chimie Analytique – Chimie Organique – Biophysique 2023:vi-vi
Publikováno v:
ChemInform. 46
7-Azaindoles are versatile building blocks, especially in medicinal chemistry, where they serve as bioisosteres of indoles or purines. Herein, we present a novel rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrro
Publikováno v:
Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2015, 80 (6), pp.3264-3269. ⟨10.1021/jo502784h⟩
Journal of Organic Chemistry, American Chemical Society, 2015, 80 (6), pp.3264-3269. ⟨10.1021/jo502784h⟩
International audience; 7-Azaindoles are versatile building blocks, especially in medicinal chemistry, where they serve as bioisosteres of indoles or purines. Herein, we present a novel rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debd3fa59e330667278eaf2ee9abf061
https://hal.archives-ouvertes.fr/hal-02903786
https://hal.archives-ouvertes.fr/hal-02903786
Autor:
Jerome F. Hayes, Michael Shipman, Sabitur Rahman, Gildas Prie, Natacha Prevost, Cyril Montagne, Jason J. Shiers
Publikováno v:
Tetrahedron. 62:8447-8457
2-Methyleneaziridinyl anions can be produced by selective deprotonation of the parent aziridine at C-3 using sec-BuLi/TMEDA. Subsequent reaction with a wide variety of electrophiles including MeI, ICH2CH2CH2CH2Cl, PhCH2Br, allyl bromide, Me3SiCl, Bu3
Publikováno v:
New Journal of Chemistry. 27:432-441
Stereoselective construction of 3-trifluoromethyl conjugated dienoates, trienoates or dienynoates was achieved from ethyl (Z)-4,4,4-trifluoro-3-iodobutenoate and alkenyltin or alkynyltin reagents through the Stille reaction or under Heck–Sonogashir
Publikováno v:
Journal of Fluorine Chemistry. 117:35-41
(E)- or (Z)-perfluorinated β-enaminoesters were prepared by direct addition of primary or secondary amines to ethyl perfluoroalkynoates without any catalyst.