Výsledky vyhledávání - "Gilda M. Kalinec"

Akademický článek

Extracellular Vesicles From Auditory Cells as Nanocarriers for Anti-inflammatory Drugs and Pro-resolving Mediators

Autor: Gilda M. Kalinec, Lucy Gao, Whitaker Cohn, Julian P. Whitelegge, Kym F. Faull, Federico Kalinec

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Drug- and noise-related hearing loss are both associated with inflammatory responses in the inner ear. We propose that intracochlear delivery of a combination of pro-resolving mediators, specialized proteins and lipids that accelerate the return to h

Externí odkaz: https://doaj.org/article/30297a81b9114217a9408dfa846f277e

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Akademický článek

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss

Autor: Gilda M. Kalinec, Gwen Lomberk, Raul A. Urrutia, Federico Kalinec

Publikováno v: Frontiers in Cellular Neuroscience, Vol 11 (2017)

A significant number of studies support the idea that inflammatory responses are intimately associated with drug-, noise- and age-related hearing loss (DRHL, NRHL and ARHL). Consequently, several clinical strategies aimed at reducing auditory dysfunc

Externí odkaz: https://doaj.org/article/739d4f13b5e94c3c98756de076297d0f

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Extracellular Vesicles From Auditory Cells as Nanocarriers for Anti-inflammatory Drugs and Pro-resolving Mediators

Autor: Lucy Gao, Kym F. Faull, Julian P. Whitelegge, Federico Kalinec, Gilda M. Kalinec, Whitaker Cohn

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)
Frontiers in Cellular Neuroscience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ada797ac7609c7c0a5c431c590ae36d
https://www.frontiersin.org/article/10.3389/fncel.2019.00530/full

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Preliminary Characterization of Extracellular Vesicles From Auditory HEI-OC1 Cells

Autor: Federico Kalinec, Gilda M. Kalinec, Julian P. Whitelegge, Kym F. Faull, Whitaker Cohn

Publikováno v: The Annals of otology, rhinology, and laryngology, vol 128, iss 6_suppl

Objectives:Isolate, purify, and characterize extracellular vesicles (EVs) obtained from auditory HEI-OC1 cells, and evaluate their suitability for intracochlear transport and delivery of pharmacological drugs and/or pro-resolution mediators of acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb49722daca112412269205d384e82f
https://pubmed.ncbi.nlm.nih.gov/31092033

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HEI-OC1 cells as a model for investigating drug cytotoxicity

Autor: Channy Park, Federico Kalinec, Gilda M. Kalinec, Pru Thein

Publikováno v: Hearing Research. 335:105-117

The House Ear Institute-Organ of Corti 1 (HEI-OC1) is one of the few, and arguable the most used, mouse auditory cell line available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, it has been used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910a2908ec7da9be00675e332483292c
https://doi.org/10.1016/j.heares.2016.02.019

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HEI-OC1 cells as a model for investigating prestin function

Autor: Gilda M. Kalinec, Channy Park, Pru Thein, Federico Kalinec

Publikováno v: Hearing Research. 335:9-17

The House Ear Institute-Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5). Since its discovery fifteen years ago, and because of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eb6fd96b5183b846c5ddaaeaf44b0f
https://doi.org/10.1016/j.heares.2016.02.001

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Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss

Autor: Gwen Lomberk, Federico Kalinec, Raul Urrutia, Gilda M. Kalinec

Publikováno v: Frontiers in Cellular Neuroscience, Vol 11 (2017)
Frontiers in Cellular Neuroscience
Kalinec, GM; Lomberk, G; Urrutia, RA; & Kalinec, F. (2017). Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise-and Age-related Hearing Loss. FRONTIERS IN CELLULAR NEUROSCIENCE, 11. doi: 10.3389/fncel.2017.00192. UCLA: Retrieved from: http://www.escholarship.org/uc/item/45h1k38c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8031709798650309dd111cd92835a956
http://journal.frontiersin.org/article/10.3389/fncel.2017.00192/full

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Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways

Autor: Federico Kalinec, Gilda M. Kalinec, Joshua G. Yorgason, Arya Parsa, Pru Thein, Raul Urrutia, William M. Luxford

Publikováno v: Kalinec, GM; Thein, P; Parsa, A; Yorgason, J; Luxford, W; Urrutia, R; et al.(2014). Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. Hearing Research, 313, 26-37. doi: 10.1016/j.heares.2014.04.007. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4sn0r7gx

Pain relievers containing N-acetyl-para-aminophenol, also called APAP, acetaminophen or paracetamol, in combination with opioid narcotics are top-selling pharmaceuticals in the U.S. Individuals who abuse these drugs for as little as sixty days can de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4d370c25ee3b521247a6e39b550cec
https://doi.org/10.1016/j.heares.2014.04.007

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Working with Auditory HEI-OC1 Cells

Autor: Federico Kalinec, Channy Park, Gilda M. Kalinec, Pru Thein

Publikováno v: Kalinec, GM; Park, C; Thein, P; & Kalinec, F. (2016). Working with Auditory HEI-OC1 Cells. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (115). doi: 10.3791/54425. UCLA: Retrieved from: http://www.escholarship.org/uc/item/07t1c0x8
Journal of visualized experiments : JoVE, iss 115

HEI-OC1 is one of the few mouse auditory cell lines available for research purposes. Originally proposed as an in vitro system for screening of ototoxic drugs, these cells have been used to investigate drug-activated apoptotic pathways, autophagy, se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5512a5b4becc01520e285dd9039d7f8c
http://www.escholarship.org/uc/item/07t1c0x8

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Glucocorticoid-stimulated, transcription-independent release of annexin A1 by cochlear Hensen cells

Autor: D Guerrero, Federico Kalinec, A Maricle, Bulbul Chakravarti, Paul Webster, Gilda M. Kalinec, Deb N. Chakravarti, R Gellibolian

Publikováno v: British Journal of Pharmacology. 158:1820-1834

Background and purpose: The current clinical strategy to protect the auditory organ against inflammatory damage by migrating leukocytes is the local delivery of glucocorticoids. However, the mechanism by which glucocorticoids confer this protection r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36fa3f3b694d6620c4723d9da68dd7b3
https://doi.org/10.1111/j.1476-5381.2009.00473.x

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